Dopamine modulates default mode network deactivation in elderly individuals during the Tower of London task.
Identifieur interne : 000A85 ( Ncbi/Merge ); précédent : 000A84; suivant : 000A86Dopamine modulates default mode network deactivation in elderly individuals during the Tower of London task.
Auteurs : Atsuko Nagano-Saito [Canada] ; Jiaqiang Liu ; Julien Doyon ; Alain DagherSource :
- Neuroscience letters [ 1872-7972 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Apomorphine, Brain Mapping, Dopamine (metabolism), Dopamine Agonists, Female, Gyrus Cinguli (blood supply), Gyrus Cinguli (drug effects), HIV Infections (diagnostic imaging), HIV Infections (pathology), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net (blood supply), Neuropsychological Tests, Parkinson Disease (diagnostic imaging), Parkinson Disease (pathology), Positron-Emission Tomography (methods), Prefrontal Cortex (blood supply), Prefrontal Cortex (drug effects), Problem Solving (physiology).
- MESH :
- chemical , metabolism : Dopamine.
- chemical : Apomorphine, Dopamine Agonists.
- blood supply : Gyrus Cinguli, Nerve Net, Prefrontal Cortex.
- diagnostic imaging : HIV Infections, Parkinson Disease.
- drug effects : Gyrus Cinguli, Prefrontal Cortex.
- methods : Positron-Emission Tomography.
- pathology : HIV Infections, Parkinson Disease.
- physiology : Problem Solving.
- Aged, Analysis of Variance, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests.
Abstract
Task-induced deactivation is frequently reported in the ventro-medial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC), regions considered to belong to the default mode network. To investigate the effect of dopamine on task-induced deactivation, we used positron emission tomography to measure cerebral blood flow during performance of the Tower of London task before and after administration of the dopamine receptor agonist apomorphine in six healthy volunteers (49-66 years old) and six Parkinson disease patients (52-69 years old). Although task-induced deactivation was observed in the vmPFC and PCC in both groups and in both conditions, an inverse correlation between activation and problem complexity was observed in the vmPFC only in the apomorphine condition.
DOI: 10.1016/j.neulet.2009.04.025
PubMed: 19442867
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Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name></author><author><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19442867</idno><idno type="pmid">19442867</idno><idno type="doi">10.1016/j.neulet.2009.04.025</idno><idno type="wicri:Area/PubMed/Corpus">000E55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E55</idno><idno type="wicri:Area/PubMed/Curation">000E55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E55</idno><idno type="wicri:Area/PubMed/Checkpoint">000E55</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E55</idno><idno type="wicri:Area/Ncbi/Merge">000A85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title 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last="Doyon">Julien Doyon</name></author><author><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name></author></analytic><series><title level="j">Neuroscience letters</title><idno type="eISSN">1872-7972</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Apomorphine</term><term>Brain Mapping</term><term>Dopamine (metabolism)</term><term>Dopamine Agonists</term><term>Female</term><term>Gyrus Cinguli (blood supply)</term><term>Gyrus Cinguli (drug effects)</term><term>HIV Infections (diagnostic imaging)</term><term>HIV Infections (pathology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nerve Net (blood supply)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (pathology)</term><term>Positron-Emission Tomography (methods)</term><term>Prefrontal Cortex (blood supply)</term><term>Prefrontal Cortex (drug effects)</term><term>Problem Solving (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Apomorphine</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Gyrus Cinguli</term><term>Nerve Net</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>HIV Infections</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gyrus Cinguli</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>HIV Infections</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Problem Solving</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Task-induced deactivation is frequently reported in the ventro-medial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC), regions considered to belong to the default mode network. To investigate the effect of dopamine on task-induced deactivation, we used positron emission tomography to measure cerebral blood flow during performance of the Tower of London task before and after administration of the dopamine receptor agonist apomorphine in six healthy volunteers (49-66 years old) and six Parkinson disease patients (52-69 years old). Although task-induced deactivation was observed in the vmPFC and PCC in both groups and in both conditions, an inverse correlation between activation and problem complexity was observed in the vmPFC only in the apomorphine condition.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19442867</PMID><DateCreated><Year>2009</Year><Month>05</Month><Day>15</Day></DateCreated><DateCompleted><Year>2009</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7972</ISSN><JournalIssue CitedMedium="Internet"><Volume>458</Volume><Issue>1</Issue><PubDate><Year>2009</Year><Month>Jul</Month><Day>10</Day></PubDate></JournalIssue><Title>Neuroscience letters</Title><ISOAbbreviation>Neurosci. Lett.</ISOAbbreviation></Journal><ArticleTitle>Dopamine modulates default mode network deactivation in elderly individuals during the Tower of London task.</ArticleTitle><Pagination><MedlinePgn>1-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neulet.2009.04.025</ELocationID><Abstract><AbstractText>Task-induced deactivation is frequently reported in the ventro-medial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC), regions considered to belong to the default mode network. To investigate the effect of dopamine on task-induced deactivation, we used positron emission tomography to measure cerebral blood flow during performance of the Tower of London task before and after administration of the dopamine receptor agonist apomorphine in six healthy volunteers (49-66 years old) and six Parkinson disease patients (52-69 years old). Although task-induced deactivation was observed in the vmPFC and PCC in both groups and in both conditions, an inverse correlation between activation and problem complexity was observed in the vmPFC only in the apomorphine condition.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nagano-Saito</LastName><ForeName>Atsuko</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, Quebec, Canada. atsuko@bic.mni.mcgill.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jiaqiang</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Doyon</LastName><ForeName>Julien</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Dagher</LastName><ForeName>Alain</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType 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uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name><name sortKey="Liu, Jiaqiang" sort="Liu, Jiaqiang" uniqKey="Liu J" first="Jiaqiang" last="Liu">Jiaqiang Liu</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Nagano Saito, Atsuko" sort="Nagano Saito, Atsuko" uniqKey="Nagano Saito A" first="Atsuko" last="Nagano-Saito">Atsuko Nagano-Saito</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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