Impaired presynaptic inhibition in the motor cortex in Parkinson disease.
Identifieur interne : 000A40 ( Ncbi/Merge ); précédent : 000A39; suivant : 000A41Impaired presynaptic inhibition in the motor cortex in Parkinson disease.
Auteurs : J. Chu [Canada] ; A. Wagle-Shukla ; C. Gunraj ; A E Lang ; R. ChenSource :
- Neurology [ 1526-632X ] ; 2009.
English descriptors
- KwdEn :
- Aged, Electromyography (methods), Evoked Potentials, Motor (physiology), Female, Humans, Male, Middle Aged, Motor Cortex (pathology), Motor Cortex (physiology), Neural Inhibition (physiology), Parkinson Disease (physiopathology), Presynaptic Terminals (pathology), Presynaptic Terminals (physiology), Transcranial Magnetic Stimulation (methods).
- MESH :
- methods : Electromyography, Transcranial Magnetic Stimulation.
- pathology : Motor Cortex, Presynaptic Terminals.
- physiology : Evoked Potentials, Motor, Motor Cortex, Neural Inhibition, Presynaptic Terminals.
- physiopathology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Intracortical inhibition in the motor cortex may be measured with short interval intracortical inhibition (SICI), likely mediated by GABA(A) receptors, and long interval intracortical inhibition (LICI), likely mediated by GABA(B) receptors. Separate neuronal populations mediate SICI and LICI, and LICI inhibits SICI, likely through GABA(B) mediated presynaptic inhibition. The purpose of this study was to test the hypothesis that cortical presynaptic inhibition in Parkinson disease (PD) is impaired.
DOI: 10.1212/01.wnl.0000343881.27524.e8
PubMed: 19255412
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Wagle-Shukla</name></author><author><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C" last="Gunraj">C. Gunraj</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R" last="Chen">R. Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19255412</idno><idno type="pmid">19255412</idno><idno type="doi">10.1212/01.wnl.0000343881.27524.e8</idno><idno type="wicri:Area/PubMed/Corpus">000E89</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E89</idno><idno type="wicri:Area/PubMed/Curation">000E89</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E89</idno><idno type="wicri:Area/PubMed/Checkpoint">000E89</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E89</idno><idno type="wicri:Area/Ncbi/Merge">000A40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired presynaptic inhibition in the motor cortex in Parkinson disease.</title><author><name sortKey="Chu, J" sort="Chu, J" uniqKey="Chu J" first="J" last="Chu">J. Chu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A" last="Wagle-Shukla">A. Wagle-Shukla</name></author><author><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C" last="Gunraj">C. Gunraj</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R" last="Chen">R. Chen</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Electromyography (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (pathology)</term><term>Motor Cortex (physiology)</term><term>Neural Inhibition (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Presynaptic Terminals (pathology)</term><term>Presynaptic Terminals (physiology)</term><term>Transcranial Magnetic Stimulation (methods)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Motor Cortex</term><term>Presynaptic Terminals</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Motor Cortex</term><term>Neural Inhibition</term><term>Presynaptic Terminals</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intracortical inhibition in the motor cortex may be measured with short interval intracortical inhibition (SICI), likely mediated by GABA(A) receptors, and long interval intracortical inhibition (LICI), likely mediated by GABA(B) receptors. Separate neuronal populations mediate SICI and LICI, and LICI inhibits SICI, likely through GABA(B) mediated presynaptic inhibition. The purpose of this study was to test the hypothesis that cortical presynaptic inhibition in Parkinson disease (PD) is impaired.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19255412</PMID><DateCreated><Year>2009</Year><Month>03</Month><Day>03</Day></DateCreated><DateCompleted><Year>2009</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2009</Year><Month>03</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>72</Volume><Issue>9</Issue><PubDate><Year>2009</Year><Month>Mar</Month><Day>03</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Impaired presynaptic inhibition in the motor cortex in Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>842-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/01.wnl.0000343881.27524.e8</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Intracortical inhibition in the motor cortex may be measured with short interval intracortical inhibition (SICI), likely mediated by GABA(A) receptors, and long interval intracortical inhibition (LICI), likely mediated by GABA(B) receptors. Separate neuronal populations mediate SICI and LICI, and LICI inhibits SICI, likely through GABA(B) mediated presynaptic inhibition. The purpose of this study was to test the hypothesis that cortical presynaptic inhibition in Parkinson disease (PD) is impaired.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Eleven patients with PD were studied at rest both OFF and ON dopaminergic medications and the results were compared to nine healthy, age-matched controls. Motor evoked potentials were recorded from the first dorsal interosseous muscle and a triple-stimulus transcranial magnetic stimulation paradigm was used to evaluate SICI in the presence of LICI. The interstimulus interval (ISI) for SICI was 2 msec and LICI was studied at 100 (LICI(100)) and 150 msec (LICI(150)) ISIs.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no difference in SICI between the controls and PD ON and PD OFF groups. LICI(100) was stronger than LICI(150) and both were reduced in the PD ON and OFF groups. LICI(100) led to a much greater reduction in SICI in the control group compared to both the PD OFF and ON groups. LICI(150) caused no significant change in SICI with no significant difference between the controls and PD OFF and PD ON groups.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The inhibitory effect of long interval intracortical inhibition on short interval intracortical inhibition, likely representing presynpatic inhibition in the motor cortex, is decreased in Parkinson disease and may be a nondopaminergic feature of the disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Neurology, Department of Medicine, University of Toronto and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagle-Shukla</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gunraj</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>A E</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>R</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004576" MajorTopicYN="N">Electromyography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019054" MajorTopicYN="N">Evoked Potentials, Motor</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009433" MajorTopicYN="N">Neural Inhibition</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017729" MajorTopicYN="N">Presynaptic Terminals</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050781" MajorTopicYN="N">Transcranial Magnetic Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>3</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>3</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>3</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19255412</ArticleId><ArticleId IdType="pii">72/9/842</ArticleId><ArticleId IdType="doi">10.1212/01.wnl.0000343881.27524.e8</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Chen, R" sort="Chen, R" uniqKey="Chen R" first="R" last="Chen">R. Chen</name><name sortKey="Gunraj, C" sort="Gunraj, C" uniqKey="Gunraj C" first="C" last="Gunraj">C. Gunraj</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name><name sortKey="Wagle Shukla, A" sort="Wagle Shukla, A" uniqKey="Wagle Shukla A" first="A" last="Wagle-Shukla">A. Wagle-Shukla</name></noCountry><country name="Canada"><noRegion><name sortKey="Chu, J" sort="Chu, J" uniqKey="Chu J" first="J" last="Chu">J. Chu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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