ParkinsonCanadaV1, Ncbi, Merge, bibRecord, 000A38

Personality, addiction, dopamine: insights from Parkinson's disease.

Identifieur interne : 000A38 ( Ncbi/Merge ); précédent : 000A37; suivant : 000A39

Personality, addiction, dopamine: insights from Parkinson's disease.

Auteurs : Alain Dagher [Canada] ; Trevor W. Robbins

Source :

Neuron [ 1097-4199 ] ; 2009.

RBID : pubmed:19249271

English descriptors

KwdEn :
- Antiparkinson Agents, Behavior, Addictive (physiopathology), Behavior, Addictive (psychology), Dopamine (physiology), Gambling (psychology), Humans, Impulsive Behavior (physiopathology), Impulsive Behavior (psychology), Learning (physiology), Neostriatum (physiopathology), Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Personality (physiology), Positron-Emission Tomography, Substance-Related Disorders (psychology).
MESH :
- chemical , physiology : Dopamine.
- chemical : Antiparkinson Agents.
- diagnostic imaging : Parkinson Disease.
- physiology : Learning, Personality.
- physiopathology : Behavior, Addictive, Impulsive Behavior, Neostriatum, Parkinson Disease.
- psychology : Behavior, Addictive, Gambling, Impulsive Behavior, Parkinson Disease, Substance-Related Disorders.
- Humans, Positron-Emission Tomography.

Abstract

In rare instances, patients with Parkinson's disease (PD) may become addicted to their own medication or develop behavioral addictions such as pathological gambling. This is surprising because PD patients typically have a very low incidence of drug abuse and display a personality type that is the polar opposite of the addictive personality. These rare addictive syndromes, which appear to result from excessive dopaminergic medication use, illustrate the link between dopamine, personality, and addiction. We describe the clinical phenomena and attempt to relate them to current models of learning and addiction. We conclude that persistently elevated dopaminergic stimulation promotes the development and maintenance of addictive behaviors.

DOI: 10.1016/j.neuron.2009.01.031
PubMed: 19249271

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pubmed:19249271

Le document en format XML

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<front><div type="abstract" xml:lang="en">In rare instances, patients with Parkinson's disease (PD) may become addicted to their own medication or develop behavioral addictions such as pathological gambling. This is surprising because PD patients typically have a very low incidence of drug abuse and display a personality type that is the polar opposite of the addictive personality. These rare addictive syndromes, which appear to result from excessive dopaminergic medication use, illustrate the link between dopamine, personality, and addiction. We describe the clinical phenomena and attempt to relate them to current models of learning and addiction. We conclude that persistently elevated dopaminergic stimulation promotes the development and maintenance of addictive behaviors.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Personality, addiction, dopamine: insights from Parkinson's disease.

Personality, addiction, dopamine: insights from Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

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