Alpha Synuclein Protein Levels are Increased in Serum from Recently Abstinent Cocaine Abusers
Identifieur interne : 000846 ( Ncbi/Merge ); précédent : 000845; suivant : 000847Alpha Synuclein Protein Levels are Increased in Serum from Recently Abstinent Cocaine Abusers
Auteurs : Deborah C. Mash [États-Unis] ; Nikhil Adi [États-Unis] ; Linda Duque [États-Unis] ; John Pablo [États-Unis] ; Mahendra Kumar [États-Unis] ; Frank R. Ervin [Canada]Source :
- Drug and alcohol dependence [ 0376-8716 ] ; 2007.
Abstract
Alpha synuclein is increased in dopamine neurons of cocaine abusers and in rats whose alcohol preference is inbred. Recent studies have shown increased alpha-synuclein protein expression in serum of alcoholic patients that is linked with severity of alcohol craving. The aim of this study was to analyze the serum levels of alpha synuclein in healthy subjects and in recently abstinent cocaine abusers. Alpha synuclein protein expression was measured by enzyme-linked immunosorbent assay in serum specimens obtained from 38 recently abstinent cocaine dependent patients and 14 control subjects. The presence of cocaine dependence disorder was based on the Structured Clinical Interview (DSM-IV). Drug severity was assessed by the Addiction Severity Index ratings and composite measures. Scores of the intensity and frequency of cocaine craving episodes were obtained from the Minnesota Cocaine Craving Questionnaire. The serum concentrations of alpha synuclein in cocaine dependent patients were significantly higher as compared with age-matched drug-free controls (p < 0.001). Alpha synuclein levels in blood were significantly correlated with the intensity (r = 0.60, p < 0.001) and frequency (r = 0.64. p < 0.001) of cocaine craving and with thirty days of cocaine use in the prior month before entry to treatment (r = 0.56, p < 0.005). However, there was no correlation between the serum protein levels of alpha synuclein and age in either group. This report is the first demonstration of altered alpha synuclein levels in peripheral blood from cocaine abusers. These data agree with previous reports in postmortem brain of cocaine abusers and provide support for an association between alpha synuclein and cocaine dependence.
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DOI: 10.1016/j.drugalcdep.2007.09.020
PubMed: 18055133
PubMed Central: 2366137
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Neurology, Miller School of Medicine, Miami, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Dept. Neurology, Miller School of Medicine, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Pablo, John" sort="Pablo, John" uniqKey="Pablo J" first="John" last="Pablo">John Pablo</name><affiliation wicri:level="2"><nlm:aff id="A1">Dept. Neurology, Miller School of Medicine, Miami, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Dept. Neurology, Miller School of Medicine, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Kumar, Mahendra" sort="Kumar, Mahendra" uniqKey="Kumar M" first="Mahendra" last="Kumar">Mahendra Kumar</name><affiliation wicri:level="2"><nlm:aff id="A2">Dept. 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Psychiatric and Behavioral Genetics, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author></analytic><series><title level="j">Drug and alcohol dependence</title><idno type="ISSN">0376-8716</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Alpha synuclein is increased in dopamine neurons of cocaine abusers and in rats whose alcohol preference is inbred. Recent studies have shown increased alpha-synuclein protein expression in serum of alcoholic patients that is linked with severity of alcohol craving. The aim of this study was to analyze the serum levels of alpha synuclein in healthy subjects and in recently abstinent cocaine abusers. Alpha synuclein protein expression was measured by enzyme-linked immunosorbent assay in serum specimens obtained from 38 recently abstinent cocaine dependent patients and 14 control subjects. The presence of cocaine dependence disorder was based on the Structured Clinical Interview (DSM-IV). Drug severity was assessed by the Addiction Severity Index ratings and composite measures. Scores of the intensity and frequency of cocaine craving episodes were obtained from the Minnesota Cocaine Craving Questionnaire. The serum concentrations of alpha synuclein in cocaine dependent patients were significantly higher as compared with age-matched drug-free controls (p < 0.001). Alpha synuclein levels in blood were significantly correlated with the intensity (r = 0.60, p < 0.001) and frequency (r = 0.64. p < 0.001) of cocaine craving and with thirty days of cocaine use in the prior month before entry to treatment (r = 0.56, p < 0.005). However, there was no correlation between the serum protein levels of alpha synuclein and age in either group. This report is the first demonstration of altered alpha synuclein levels in peripheral blood from cocaine abusers. These data agree with previous reports in postmortem brain of cocaine abusers and provide support for an association between alpha synuclein and cocaine dependence.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7513587</journal-id><journal-id journal-id-type="pubmed-jr-id">3445</journal-id><journal-id journal-id-type="nlm-ta">Drug Alcohol Depend</journal-id><journal-title>Drug and alcohol dependence</journal-title><issn pub-type="ppub">0376-8716</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18055133</article-id><article-id pub-id-type="pmc">2366137</article-id><article-id pub-id-type="manuscript">NIHMS41857</article-id><article-id pub-id-type="doi">10.1016/j.drugalcdep.2007.09.020</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Alpha Synuclein Protein Levels are Increased in Serum from Recently Abstinent Cocaine Abusers</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mash</surname><given-names>Deborah C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Adi</surname><given-names>Nikhil</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Duque</surname><given-names>Linda</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pablo</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Mahendra</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ervin</surname><given-names>Frank R.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Dept. Neurology, Miller School of Medicine, Miami, FL</aff><aff id="A2"><label>2</label>Dept. Psychiatry, Miller School of Medicine, Miami, FL</aff><aff id="A3"><label>3</label>Dept. Psychiatric and Behavioral Genetics, McGill University, Montreal, Canada</aff><author-notes><corresp id="cor1"><label>*</label><bold>Corresponding Author:</bold> Deborah C. Mash, Ph.D., Dept. Neurology (D4-5), 1501 N.W. 9<sup>th</sup> Avenue, Miami, FL 33136, Phone: (305)243-5888 Fax: (305)243-3649, <email>dmash@med.miami.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>3</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>4</day><month>12</month><year>2007</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2009</year></pub-date><volume>94</volume><issue>1-3</issue><fpage>246</fpage><lpage>250</lpage><abstract><p id="P1">Alpha synuclein is increased in dopamine neurons of cocaine abusers and in rats whose alcohol preference is inbred. Recent studies have shown increased alpha-synuclein protein expression in serum of alcoholic patients that is linked with severity of alcohol craving. The aim of this study was to analyze the serum levels of alpha synuclein in healthy subjects and in recently abstinent cocaine abusers. Alpha synuclein protein expression was measured by enzyme-linked immunosorbent assay in serum specimens obtained from 38 recently abstinent cocaine dependent patients and 14 control subjects. The presence of cocaine dependence disorder was based on the Structured Clinical Interview (DSM-IV). Drug severity was assessed by the Addiction Severity Index ratings and composite measures. Scores of the intensity and frequency of cocaine craving episodes were obtained from the Minnesota Cocaine Craving Questionnaire. The serum concentrations of alpha synuclein in cocaine dependent patients were significantly higher as compared with age-matched drug-free controls (p < 0.001). Alpha synuclein levels in blood were significantly correlated with the intensity (r = 0.60, p < 0.001) and frequency (r = 0.64. p < 0.001) of cocaine craving and with thirty days of cocaine use in the prior month before entry to treatment (r = 0.56, p < 0.005). However, there was no correlation between the serum protein levels of alpha synuclein and age in either group. This report is the first demonstration of altered alpha synuclein levels in peripheral blood from cocaine abusers. These data agree with previous reports in postmortem brain of cocaine abusers and provide support for an association between alpha synuclein and cocaine dependence.</p></abstract><kwd-group><kwd>Cocaine</kwd><kwd>serum</kwd><kwd>dopamine</kwd><kwd>craving</kwd><kwd>synuclein</kwd></kwd-group><contract-num rid="DA1">R01 DA006227-15</contract-num><contract-sponsor id="DA1">National Institute on Drug Abuse : NIDA</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Floride</li><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Mash, Deborah C" sort="Mash, Deborah C" uniqKey="Mash D" first="Deborah C." last="Mash">Deborah C. Mash</name></region><name sortKey="Adi, Nikhil" sort="Adi, Nikhil" uniqKey="Adi N" first="Nikhil" last="Adi">Nikhil Adi</name><name sortKey="Duque, Linda" sort="Duque, Linda" uniqKey="Duque L" first="Linda" last="Duque">Linda Duque</name><name sortKey="Kumar, Mahendra" sort="Kumar, Mahendra" uniqKey="Kumar M" first="Mahendra" last="Kumar">Mahendra Kumar</name><name sortKey="Pablo, John" sort="Pablo, John" uniqKey="Pablo J" first="John" last="Pablo">John Pablo</name></country><country name="Canada"><region name="Québec"><name sortKey="Ervin, Frank R" sort="Ervin, Frank R" uniqKey="Ervin F" first="Frank R." last="Ervin">Frank R. Ervin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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