Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.
Identifieur interne : 000417 ( Ncbi/Merge ); précédent : 000416; suivant : 000418Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.
Auteurs : Cynthia Mcrae [États-Unis] ; Eva Cherin ; T Gayle Yamazaki ; Gretchen Diem ; Alexander H. Vo ; Dan Russell ; J Heiner Ellgring ; Stanley Fahn ; Paul Greene ; Sandra Dillon ; Hal Winfield ; Kimberly B. Bjugstad ; Curt R. FreedSource :
- Archives of general psychiatry [ 0003-990X ] ; 2004.
English descriptors
- KwdEn :
- Aged, Brain Tissue Transplantation, Dopamine (pharmacology), Double-Blind Method, Female, Fetal Tissue Transplantation, Humans, Male, Middle Aged, Neurons (transplantation), Parkinson Disease (psychology), Parkinson Disease (therapy), Perception, Placebo Effect, Placebos, Quality of Life, Treatment Outcome.
- MESH :
- chemical , pharmacology : Dopamine.
- psychology : Parkinson Disease.
- therapy : Parkinson Disease.
- transplantation : Neurons.
- Aged, Brain Tissue Transplantation, Double-Blind Method, Female, Fetal Tissue Transplantation, Humans, Male, Middle Aged, Perception, Placebo Effect, Placebos, Quality of Life, Treatment Outcome.
Abstract
This study was part of a large double-blind sham surgery-controlled trial designed to determine the effectiveness of transplantation of human embryonic dopamine neurons into the brains of persons with advanced Parkinson's disease. This portion of the study investigated the quality of life (QOL) of participants during the 1 year of double-blind follow-up.
DOI: 10.1001/archpsyc.61.4.412
PubMed: 15066900
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pubmed:15066900Le document en format XML
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Vo</name></author><author><name sortKey="Russell, Dan" sort="Russell, Dan" uniqKey="Russell D" first="Dan" last="Russell">Dan Russell</name></author><author><name sortKey="Ellgring, J Heiner" sort="Ellgring, J Heiner" uniqKey="Ellgring J" first="J Heiner" last="Ellgring">J Heiner Ellgring</name></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></author><author><name sortKey="Greene, Paul" sort="Greene, Paul" uniqKey="Greene P" first="Paul" last="Greene">Paul Greene</name></author><author><name sortKey="Dillon, Sandra" sort="Dillon, Sandra" uniqKey="Dillon S" first="Sandra" last="Dillon">Sandra Dillon</name></author><author><name sortKey="Winfield, Hal" sort="Winfield, Hal" uniqKey="Winfield H" first="Hal" last="Winfield">Hal Winfield</name></author><author><name sortKey="Bjugstad, Kimberly B" sort="Bjugstad, Kimberly B" uniqKey="Bjugstad K" first="Kimberly B" last="Bjugstad">Kimberly B. 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Vo</name></author><author><name sortKey="Russell, Dan" sort="Russell, Dan" uniqKey="Russell D" first="Dan" last="Russell">Dan Russell</name></author><author><name sortKey="Ellgring, J Heiner" sort="Ellgring, J Heiner" uniqKey="Ellgring J" first="J Heiner" last="Ellgring">J Heiner Ellgring</name></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></author><author><name sortKey="Greene, Paul" sort="Greene, Paul" uniqKey="Greene P" first="Paul" last="Greene">Paul Greene</name></author><author><name sortKey="Dillon, Sandra" sort="Dillon, Sandra" uniqKey="Dillon S" first="Sandra" last="Dillon">Sandra Dillon</name></author><author><name sortKey="Winfield, Hal" sort="Winfield, Hal" uniqKey="Winfield H" first="Hal" last="Winfield">Hal Winfield</name></author><author><name sortKey="Bjugstad, Kimberly B" sort="Bjugstad, Kimberly B" uniqKey="Bjugstad K" first="Kimberly B" last="Bjugstad">Kimberly B. Bjugstad</name></author><author><name sortKey="Freed, Curt R" sort="Freed, Curt R" uniqKey="Freed C" first="Curt R" last="Freed">Curt R. Freed</name></author></analytic><series><title level="j">Archives of general psychiatry</title><idno type="ISSN">0003-990X</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Tissue Transplantation</term><term>Dopamine (pharmacology)</term><term>Double-Blind Method</term><term>Female</term><term>Fetal Tissue Transplantation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurons (transplantation)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Perception</term><term>Placebo Effect</term><term>Placebos</term><term>Quality of Life</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Tissue Transplantation</term><term>Double-Blind Method</term><term>Female</term><term>Fetal Tissue Transplantation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Perception</term><term>Placebo Effect</term><term>Placebos</term><term>Quality of Life</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was part of a large double-blind sham surgery-controlled trial designed to determine the effectiveness of transplantation of human embryonic dopamine neurons into the brains of persons with advanced Parkinson's disease. This portion of the study investigated the quality of life (QOL) of participants during the 1 year of double-blind follow-up.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15066900</PMID><DateCreated><Year>2004</Year><Month>04</Month><Day>06</Day></DateCreated><DateCompleted><Year>2004</Year><Month>04</Month><Day>27</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0003-990X</ISSN><JournalIssue CitedMedium="Print"><Volume>61</Volume><Issue>4</Issue><PubDate><Year>2004</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Archives of general psychiatry</Title><ISOAbbreviation>Arch. Gen. Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.</ArticleTitle><Pagination><MedlinePgn>412-20</MedlinePgn></Pagination><Abstract><AbstractText Label="CONTEXT" NlmCategory="BACKGROUND">This study was part of a large double-blind sham surgery-controlled trial designed to determine the effectiveness of transplantation of human embryonic dopamine neurons into the brains of persons with advanced Parkinson's disease. This portion of the study investigated the quality of life (QOL) of participants during the 1 year of double-blind follow-up.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine whether QOL improved more in the transplant group than in the sham surgery group and to investigate outcomes at 1 year based on perceived treatment (the type of surgery patients thought they received).</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Participants were randomly assigned to receive either the transplant or sham surgery. Reported results are from the 1-year double-blind period.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Participants were recruited from across the United States and Canada. Assessment and surgery were conducted at 2 separate university medical centers.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">A volunteer sample of 40 persons with idiopathic Parkinson's disease participated in the transplant ("parent") study, and 30 agreed to participate in the related QOL study: 12 received the transplant and 18 received sham surgery.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Interventions in the parent study were transplantation and sham brain surgery. Assessments of QOL were made at baseline and 4, 8, and 12 months after surgery.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURES" NlmCategory="METHODS">Comparison of the actual transplant and sham surgery groups and the perceived treatment groups on QOL and medical outcomes. We also investigated change over time.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were 2 differences or changes over time in the transplant and sham surgery groups. Based on perceived treatment, or treatment patients thought they received, there were numerous differences and changes over time. In all cases, those who thought they received the transplant reported better scores. Blind ratings by medical staff showed similar results.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The placebo effect was very strong in this study, demonstrating the value of placebo-controlled surgical trials.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McRae</LastName><ForeName>Cynthia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>College of Education, University of Denver, Denver, CO 80208, USA. cmcrae@du.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cherin</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Yamazaki</LastName><ForeName>T Gayle</ForeName><Initials>TG</Initials></Author><Author ValidYN="Y"><LastName>Diem</LastName><ForeName>Gretchen</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Vo</LastName><ForeName>Alexander H</ForeName><Initials>AH</Initials></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Dan</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Ellgring</LastName><ForeName>J Heiner</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Fahn</LastName><ForeName>Stanley</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Greene</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Dillon</LastName><ForeName>Sandra</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Winfield</LastName><ForeName>Hal</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Bjugstad</LastName><ForeName>Kimberly B</ForeName><Initials>KB</Initials></Author><Author ValidYN="Y"><LastName>Freed</LastName><ForeName>Curt R</ForeName><Initials>CR</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS32368</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R29 NS32009-05</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Gen Psychiatry</MedlineTA><NlmUniqueID>0372435</NlmUniqueID><ISSNLinking>0003-990X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010919">Placebos</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Arch Gen Psychiatry. 2004 Jun;61(6):627</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016380" MajorTopicYN="Y">Brain Tissue Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016332" MajorTopicYN="Y">Fetal Tissue Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010465" MajorTopicYN="N">Perception</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015990" MajorTopicYN="N">Placebo Effect</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010919" MajorTopicYN="N">Placebos</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>4</Month><Day>7</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>4</Month><Day>28</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>4</Month><Day>7</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15066900</ArticleId><ArticleId IdType="doi">10.1001/archpsyc.61.4.412</ArticleId><ArticleId IdType="pii">61/4/412</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Colorado</li></region></list><tree><noCountry><name sortKey="Bjugstad, Kimberly B" sort="Bjugstad, Kimberly B" uniqKey="Bjugstad K" first="Kimberly B" last="Bjugstad">Kimberly B. Bjugstad</name><name sortKey="Cherin, Eva" sort="Cherin, Eva" uniqKey="Cherin E" first="Eva" last="Cherin">Eva Cherin</name><name sortKey="Diem, Gretchen" sort="Diem, Gretchen" uniqKey="Diem G" first="Gretchen" last="Diem">Gretchen Diem</name><name sortKey="Dillon, Sandra" sort="Dillon, Sandra" uniqKey="Dillon S" first="Sandra" last="Dillon">Sandra Dillon</name><name sortKey="Ellgring, J Heiner" sort="Ellgring, J Heiner" uniqKey="Ellgring J" first="J Heiner" last="Ellgring">J Heiner Ellgring</name><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><name sortKey="Freed, Curt R" sort="Freed, Curt R" uniqKey="Freed C" first="Curt R" last="Freed">Curt R. Freed</name><name sortKey="Greene, Paul" sort="Greene, Paul" uniqKey="Greene P" first="Paul" last="Greene">Paul Greene</name><name sortKey="Russell, Dan" sort="Russell, Dan" uniqKey="Russell D" first="Dan" last="Russell">Dan Russell</name><name sortKey="Vo, Alexander H" sort="Vo, Alexander H" uniqKey="Vo A" first="Alexander H" last="Vo">Alexander H. Vo</name><name sortKey="Winfield, Hal" sort="Winfield, Hal" uniqKey="Winfield H" first="Hal" last="Winfield">Hal Winfield</name><name sortKey="Yamazaki, T Gayle" sort="Yamazaki, T Gayle" uniqKey="Yamazaki T" first="T Gayle" last="Yamazaki">T Gayle Yamazaki</name></noCountry><country name="États-Unis"><region name="Colorado"><name sortKey="Mcrae, Cynthia" sort="Mcrae, Cynthia" uniqKey="Mcrae C" first="Cynthia" last="Mcrae">Cynthia Mcrae</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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