ParkinsonCanadaV1, Ncbi, Merge, bibRecord, 000267

Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease.

Identifieur interne : 000267 ( Ncbi/Merge ); précédent : 000266; suivant : 000268

Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease.

Auteurs : Aviva Abosch [Canada] ; William D. Hutchison ; Jean A. Saint-Cyr ; Jonathan O. Dostrovsky ; Andres M. Lozano

Source :

Journal of neurosurgery [ 0022-3085 ] ; 2002.

RBID : pubmed:12450039

English descriptors

KwdEn :
- Adult, Aged, Electrophysiology (instrumentation), Female, Humans, Male, Microelectrodes, Middle Aged, Movement (physiology), Neurons (physiology), Parkinson Disease (physiopathology), Retrospective Studies, Subthalamic Nucleus (physiopathology).
MESH :
- instrumentation : Electrophysiology.
- physiology : Movement, Neurons.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- Adult, Aged, Female, Humans, Male, Microelectrodes, Middle Aged, Retrospective Studies.

Abstract

The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson disease (PD). Little is known about the neurons within the human STN that modulate movement. The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields.

DOI: 10.3171/jns.2002.97.5.1167
PubMed: 12450039

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pubmed:12450039

Le document en format XML

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<author><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada. aabosch@emory.edu</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
</author>
<author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A" last="Saint-Cyr">Jean A. Saint-Cyr</name>
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<author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O" last="Dostrovsky">Jonathan O. Dostrovsky</name>
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<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
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<author><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada. aabosch@emory.edu</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
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<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
</author>
<author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A" last="Saint-Cyr">Jean A. Saint-Cyr</name>
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<author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O" last="Dostrovsky">Jonathan O. Dostrovsky</name>
</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
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<series><title level="j">Journal of neurosurgery</title>
<idno type="ISSN">0022-3085</idno>
<imprint><date when="2002" type="published">2002</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Electrophysiology (instrumentation)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Movement (physiology)</term>
<term>Neurons (physiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Retrospective Studies</term>
<term>Subthalamic Nucleus (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electrophysiology</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
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<front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson disease (PD). Little is known about the neurons within the human STN that modulate movement. The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12450039</PMID>
<DateCreated><Year>2002</Year>
<Month>11</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2002</Year>
<Month>12</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2004</Year>
<Month>11</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3085</ISSN>
<JournalIssue CitedMedium="Print"><Volume>97</Volume>
<Issue>5</Issue>
<PubDate><Year>2002</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Journal of neurosurgery</Title>
<ISOAbbreviation>J. Neurosurg.</ISOAbbreviation>
</Journal>
<ArticleTitle>Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease.</ArticleTitle>
<Pagination><MedlinePgn>1167-72</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECT" NlmCategory="OBJECTIVE">The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson disease (PD). Little is known about the neurons within the human STN that modulate movement. The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Data were retrospectively collected from microelectrode recordings that had been obtained in 38 patients with PD during surgery for placement of STN deep brain stimulation electrodes. The recordings had been obtained in awake, nonsedated patients. Antiparkinsonian medications were withheld the night before surgery. Neuronal discharges were amplified, filtered, and displayed on an oscilloscope and fed to an audio monitor. The receptive fields were identified by the presence of reproducible, audible changes in the firing rate that were time-locked to the movement of specific joint(s). The median number of electrode tracks per patient was six (range two-nine). The receptive fields were identified in 278 (55%) of 510 STN neurons studied. One hundred one tracks yielded receptive field data. Fourteen percent of 64 cells tested positive for face receptive fields, 32% of 687 cells tested positive for upper-extremity receptive fields, and 21% of 242 cells tested positive for lower-extremity receptive fields. Sixty-eight cells (24%) demonstrated multiple-joint receptive fields. Ninety-three cells (65%) with movement-related receptive fields were located in the dorsal half of the STN, and 96.8% of these were located in the rostral two thirds of the STN. Analysis of receptive field locations from pooled data and along individual electrode tracks failed to reveal a consistent somatotopic organization.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Data from this study demonstrate a regional compartmentalization of neurons with movement-related receptive fields within the STN, supporting the existence of specific motor territories within the STN in patients suffering from PD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Abosch</LastName>
<ForeName>Aviva</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada. aabosch@emory.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hutchison</LastName>
<ForeName>William D</ForeName>
<Initials>WD</Initials>
</Author>
<Author ValidYN="Y"><LastName>Saint-Cyr</LastName>
<ForeName>Jean A</ForeName>
<Initials>JA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Dostrovsky</LastName>
<ForeName>Jonathan O</ForeName>
<Initials>JO</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lozano</LastName>
<ForeName>Andres M</ForeName>
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</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Neurosurg</MedlineTA>
<NlmUniqueID>0253357</NlmUniqueID>
<ISSNLinking>0022-3085</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004594" MajorTopicYN="N">Electrophysiology</DescriptorName>
<QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008839" MajorTopicYN="N">Microelectrodes</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009068" MajorTopicYN="N">Movement</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
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<tree><noCountry><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O" last="Dostrovsky">Jonathan O. Dostrovsky</name>
<name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
<name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A" last="Saint-Cyr">Jean A. Saint-Cyr</name>
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<country name="Canada"><noRegion><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease.

Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki