Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats.
Identifieur interne : 000094 ( Ncbi/Merge ); précédent : 000093; suivant : 000095Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats.
Auteurs : E F Field [Canada] ; I Q Whishaw ; S M PellisSource :
- Behavioural brain research [ 0166-4328 ] ; 2000.
English descriptors
- KwdEn :
- Animals, Biomechanical Phenomena, Catalepsy (chemically induced), Catalepsy (physiopathology), Disease Models, Animal, Dopamine Antagonists (adverse effects), Female, Gonadal Steroid Hormones (physiology), Haloperidol (adverse effects), Head-Down Tilt (physiology), Male, Parkinson Disease (physiopathology), Posture (physiology), Rats, Rats, Inbred Strains, Sex Characteristics.
- MESH :
- chemical , adverse effects : Dopamine Antagonists, Haloperidol.
- chemically induced : Catalepsy.
- chemical , physiology : Gonadal Steroid Hormones, Head-Down Tilt, Posture.
- physiopathology : Catalepsy, Parkinson Disease.
- Animals, Biomechanical Phenomena, Disease Models, Animal, Female, Male, Rats, Rats, Inbred Strains, Sex Characteristics.
Abstract
Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.
PubMed: 10762690
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001639
- to stream PubMed, to step Curation: 001639
- to stream PubMed, to step Checkpoint: 001639
Links to Exploration step
pubmed:10762690Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats.</title>
<author><name sortKey="Field, E F" sort="Field, E F" uniqKey="Field E" first="E F" last="Field">E F Field</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta</wicri:regionArea>
<wicri:noRegion>Alta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whishaw, I Q" sort="Whishaw, I Q" uniqKey="Whishaw I" first="I Q" last="Whishaw">I Q Whishaw</name>
</author>
<author><name sortKey="Pellis, S M" sort="Pellis, S M" uniqKey="Pellis S" first="S M" last="Pellis">S M Pellis</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2000">2000</date>
<idno type="RBID">pubmed:10762690</idno>
<idno type="pmid">10762690</idno>
<idno type="wicri:Area/PubMed/Corpus">001639</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001639</idno>
<idno type="wicri:Area/PubMed/Curation">001639</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001639</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001639</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001639</idno>
<idno type="wicri:Area/Ncbi/Merge">000094</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats.</title>
<author><name sortKey="Field, E F" sort="Field, E F" uniqKey="Field E" first="E F" last="Field">E F Field</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta</wicri:regionArea>
<wicri:noRegion>Alta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whishaw, I Q" sort="Whishaw, I Q" uniqKey="Whishaw I" first="I Q" last="Whishaw">I Q Whishaw</name>
</author>
<author><name sortKey="Pellis, S M" sort="Pellis, S M" uniqKey="Pellis S" first="S M" last="Pellis">S M Pellis</name>
</author>
</analytic>
<series><title level="j">Behavioural brain research</title>
<idno type="ISSN">0166-4328</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Biomechanical Phenomena</term>
<term>Catalepsy (chemically induced)</term>
<term>Catalepsy (physiopathology)</term>
<term>Disease Models, Animal</term>
<term>Dopamine Antagonists (adverse effects)</term>
<term>Female</term>
<term>Gonadal Steroid Hormones (physiology)</term>
<term>Haloperidol (adverse effects)</term>
<term>Head-Down Tilt (physiology)</term>
<term>Male</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Posture (physiology)</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Sex Characteristics</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Antagonists</term>
<term>Haloperidol</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Catalepsy</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Gonadal Steroid Hormones</term>
<term>Head-Down Tilt</term>
<term>Posture</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Catalepsy</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biomechanical Phenomena</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Sex Characteristics</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10762690</PMID>
<DateCreated><Year>2000</Year>
<Month>06</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2000</Year>
<Month>06</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0166-4328</ISSN>
<JournalIssue CitedMedium="Print"><Volume>109</Volume>
<Issue>2</Issue>
<PubDate><Year>2000</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Behavioural brain research</Title>
<ISOAbbreviation>Behav. Brain Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats.</ArticleTitle>
<Pagination><MedlinePgn>207-12</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Field</LastName>
<ForeName>E F</ForeName>
<Initials>EF</Initials>
<AffiliationInfo><Affiliation>Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Whishaw</LastName>
<ForeName>I Q</ForeName>
<Initials>IQ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pellis</LastName>
<ForeName>S M</ForeName>
<Initials>SM</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Behav Brain Res</MedlineTA>
<NlmUniqueID>8004872</NlmUniqueID>
<ISSNLinking>0166-4328</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018492">Dopamine Antagonists</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012739">Gonadal Steroid Hormones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>J6292F8L3D</RegistryNumber>
<NameOfSubstance UI="D006220">Haloperidol</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CitationSubset>S</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001696" MajorTopicYN="N">Biomechanical Phenomena</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002375" MajorTopicYN="N">Catalepsy</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018492" MajorTopicYN="N">Dopamine Antagonists</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012739" MajorTopicYN="N">Gonadal Steroid Hormones</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006220" MajorTopicYN="N">Haloperidol</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018475" MajorTopicYN="N">Head-Down Tilt</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011187" MajorTopicYN="N">Posture</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011919" MajorTopicYN="N">Rats, Inbred Strains</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012727" MajorTopicYN="N">Sex Characteristics</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year>
<Month>4</Month>
<Day>14</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2000</Year>
<Month>6</Month>
<Day>24</Day>
<Hour>11</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2000</Year>
<Month>4</Month>
<Day>14</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">10762690</ArticleId>
<ArticleId IdType="pii">S0166432899001746</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Pellis, S M" sort="Pellis, S M" uniqKey="Pellis S" first="S M" last="Pellis">S M Pellis</name>
<name sortKey="Whishaw, I Q" sort="Whishaw, I Q" uniqKey="Whishaw I" first="I Q" last="Whishaw">I Q Whishaw</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Field, E F" sort="Field, E F" uniqKey="Field E" first="E F" last="Field">E F Field</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000094 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000094 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:10762690 |texte= Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:10762690" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |