ParkinsonCanadaV1, Ncbi, Curation, bibRecord, 002449

Clinical observations on the rate of progression of idiopathic parkinsonism.

Identifieur interne : 002449 ( Ncbi/Curation ); précédent : 002448; suivant : 002450

Clinical observations on the rate of progression of idiopathic parkinsonism.

Auteurs : C S Lee [Canada] ; M. Schulzer ; E K Mak ; B J Snow ; J K Tsui ; S. Calne ; J. Hammerstad ; D B Calne

Source :

Brain : a journal of neurology [ 0006-8950 ] ; 1994.

RBID : pubmed:8032860

English descriptors

KwdEn :
- Aged, Aging, Antiparkinson Agents (administration & dosage), Female, Humans, Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (etiology), Parkinson Disease (physiopathology).
MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- etiology : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Aged, Aging, Female, Humans, Male, Middle Aged.

Abstract

The time course of evolution of clinical deficits has been a traditional guide to the nature of the aetiopathogenesis of neurological disease. We studied the influence of ageing and duration of disease on the natural history of idiopathic parkinsonism (IP). Two hundred and thirty-eight patients with IP were examined while off medication. Bradykinesia scores were analysed against patients' age and duration of disease by multiple regression. There was no significant interaction between the effects of age and of duration (P = 0.923). We conclude that age and duration of symptoms influence the natural history of IP additively and independently. Furthermore, the rate of neuronal death is more rapid in the earlier stages of evolution of the pathology; subsequently, the velocity of progression slows down to approach the rate of attrition produced by normal ageing. This time course has implications for possible models of pathogenesis.

PubMed: 8032860

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pubmed:8032860

Le document en format XML

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<author><name sortKey="Lee, C S" sort="Lee, C S" uniqKey="Lee C" first="C S" last="Lee">C S Lee</name>
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<country xml:lang="fr">Canada</country>
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<author><name sortKey="Mak, E K" sort="Mak, E K" uniqKey="Mak E" first="E K" last="Mak">E K Mak</name>
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<author><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B J" last="Snow">B J Snow</name>
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<author><name sortKey="Tsui, J K" sort="Tsui, J K" uniqKey="Tsui J" first="J K" last="Tsui">J K Tsui</name>
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<author><name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S" last="Calne">S. Calne</name>
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<author><name sortKey="Hammerstad, J" sort="Hammerstad, J" uniqKey="Hammerstad J" first="J" last="Hammerstad">J. Hammerstad</name>
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<author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia</wicri:regionArea>
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<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M" last="Schulzer">M. Schulzer</name>
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<author><name sortKey="Mak, E K" sort="Mak, E K" uniqKey="Mak E" first="E K" last="Mak">E K Mak</name>
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<author><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B J" last="Snow">B J Snow</name>
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<author><name sortKey="Hammerstad, J" sort="Hammerstad, J" uniqKey="Hammerstad J" first="J" last="Hammerstad">J. Hammerstad</name>
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<author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (physiopathology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term>
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<front><div type="abstract" xml:lang="en">The time course of evolution of clinical deficits has been a traditional guide to the nature of the aetiopathogenesis of neurological disease. We studied the influence of ageing and duration of disease on the natural history of idiopathic parkinsonism (IP). Two hundred and thirty-eight patients with IP were examined while off medication. Bradykinesia scores were analysed against patients' age and duration of disease by multiple regression. There was no significant interaction between the effects of age and of duration (P = 0.923). We conclude that age and duration of symptoms influence the natural history of IP additively and independently. Furthermore, the rate of neuronal death is more rapid in the earlier stages of evolution of the pathology; subsequently, the velocity of progression slows down to approach the rate of attrition produced by normal ageing. This time course has implications for possible models of pathogenesis.</div>
</front>
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La maladie de Parkinson au Canada (serveur d'exploration)

Clinical observations on the rate of progression of idiopathic parkinsonism.

Clinical observations on the rate of progression of idiopathic parkinsonism.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki