Quetiapine for Psychosis in Parkinson Disease and Neurodegenerative Parkinsonian Disorders: A Systematic Review.
Identifieur interne : 001F27 ( Ncbi/Curation ); précédent : 001F26; suivant : 001F28Quetiapine for Psychosis in Parkinson Disease and Neurodegenerative Parkinsonian Disorders: A Systematic Review.
Auteurs : Philippe Desmarais [Canada] ; Fadi Massoud [Canada] ; Josée Filion [Canada] ; Quoc Dinh Nguyen [Canada] ; Paulina Bajsarowicz [Canada]Source :
- Journal of geriatric psychiatry and neurology [ 0891-9887 ] ; 2016.
Abstract
We performed a systematic review of randomized controlled trials to assess the high-level evidence regarding the role of quetiapine in the treatment of psychosis in patients with neurodegenerative parkinsonian disorders. Studies were included in the qualitative review if they (1) enrolled participants with diagnosis of Parkinson disease, Lewy body dementia, or any other neurodegenerative parkinsonian disorders; (2) assessed the efficacy of quetiapine; and (3) evaluated psychotic and motor outcomes using validated tools. Of the 341 manuscripts identified, 7 studies fulfilled our inclusion criteria. The studies' risk of bias was considered low. A total of 241 participants enrolled in these trials. Heterogeneity was high due to inclusion criteria, user definitions, assessment tools, and study design. Although not causing any motor deterioration, quetiapine failed to significantly reduce psychotic symptoms compared to placebo when objectively assessed on the Brief Psychotic Rating Scale, the most frequently reported scale in these studies. High loss to follow-up and dropout rates as well as significant improvement in psychotic symptoms in the placebo groups may have affected measurements of possible positive medication effects.
DOI: 10.1177/0891988716640378
PubMed: 27056066
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000205
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000205
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000205
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001F27
Links to Exploration step
pubmed:27056066Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quetiapine for Psychosis in Parkinson Disease and Neurodegenerative Parkinsonian Disorders: A Systematic Review.</title><author><name sortKey="Desmarais, Philippe" sort="Desmarais, Philippe" uniqKey="Desmarais P" first="Philippe" last="Desmarais">Philippe Desmarais</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec, Canada philippe.desmarais.1@umontreal.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Massoud, Fadi" sort="Massoud, Fadi" uniqKey="Massoud F" first="Fadi" last="Massoud">Fadi Massoud</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier Charles LeMoyne, Longueuil, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier Charles LeMoyne, Longueuil, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Filion, Josee" sort="Filion, Josee" uniqKey="Filion J" first="Josée" last="Filion">Josée Filion</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Quoc Dinh" sort="Nguyen, Quoc Dinh" uniqKey="Nguyen Q" first="Quoc Dinh" last="Nguyen">Quoc Dinh Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Bajsarowicz, Paulina" sort="Bajsarowicz, Paulina" uniqKey="Bajsarowicz P" first="Paulina" last="Bajsarowicz">Paulina Bajsarowicz</name><affiliation wicri:level="1"><nlm:affiliation>Geriatric Psychiatry Service, Department of Psychiatry, Douglas Mental Health University Institute, Verdun, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Geriatric Psychiatry Service, Department of Psychiatry, Douglas Mental Health University Institute, Verdun, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27056066</idno><idno type="pmid">27056066</idno><idno type="doi">10.1177/0891988716640378</idno><idno type="wicri:Area/PubMed/Corpus">000205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000205</idno><idno type="wicri:Area/PubMed/Curation">000205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000205</idno><idno type="wicri:Area/PubMed/Checkpoint">000205</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000205</idno><idno type="wicri:Area/Ncbi/Merge">001F27</idno><idno type="wicri:Area/Ncbi/Curation">001F27</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quetiapine for Psychosis in Parkinson Disease and Neurodegenerative Parkinsonian Disorders: A Systematic Review.</title><author><name sortKey="Desmarais, Philippe" sort="Desmarais, Philippe" uniqKey="Desmarais P" first="Philippe" last="Desmarais">Philippe Desmarais</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec, Canada philippe.desmarais.1@umontreal.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Massoud, Fadi" sort="Massoud, Fadi" uniqKey="Massoud F" first="Fadi" last="Massoud">Fadi Massoud</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier Charles LeMoyne, Longueuil, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier Charles LeMoyne, Longueuil, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Filion, Josee" sort="Filion, Josee" uniqKey="Filion J" first="Josée" last="Filion">Josée Filion</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Quoc Dinh" sort="Nguyen, Quoc Dinh" uniqKey="Nguyen Q" first="Quoc Dinh" last="Nguyen">Quoc Dinh Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Bajsarowicz, Paulina" sort="Bajsarowicz, Paulina" uniqKey="Bajsarowicz P" first="Paulina" last="Bajsarowicz">Paulina Bajsarowicz</name><affiliation wicri:level="1"><nlm:affiliation>Geriatric Psychiatry Service, Department of Psychiatry, Douglas Mental Health University Institute, Verdun, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Geriatric Psychiatry Service, Department of Psychiatry, Douglas Mental Health University Institute, Verdun, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of geriatric psychiatry and neurology</title><idno type="ISSN">0891-9887</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a systematic review of randomized controlled trials to assess the high-level evidence regarding the role of quetiapine in the treatment of psychosis in patients with neurodegenerative parkinsonian disorders. Studies were included in the qualitative review if they (1) enrolled participants with diagnosis of Parkinson disease, Lewy body dementia, or any other neurodegenerative parkinsonian disorders; (2) assessed the efficacy of quetiapine; and (3) evaluated psychotic and motor outcomes using validated tools. Of the 341 manuscripts identified, 7 studies fulfilled our inclusion criteria. The studies' risk of bias was considered low. A total of 241 participants enrolled in these trials. Heterogeneity was high due to inclusion criteria, user definitions, assessment tools, and study design. Although not causing any motor deterioration, quetiapine failed to significantly reduce psychotic symptoms compared to placebo when objectively assessed on the Brief Psychotic Rating Scale, the most frequently reported scale in these studies. High loss to follow-up and dropout rates as well as significant improvement in psychotic symptoms in the placebo groups may have affected measurements of possible positive medication effects.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F27 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001F27 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:27056066
|texte= Quetiapine for Psychosis in Parkinson Disease and Neurodegenerative Parkinsonian Disorders: A Systematic Review.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:27056066" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |