What is a clinically important change in the Unified Dyskinesia Rating Scale in Parkinson's disease?
Identifieur interne : 001D35 ( Ncbi/Curation ); précédent : 001D34; suivant : 001D36What is a clinically important change in the Unified Dyskinesia Rating Scale in Parkinson's disease?
Auteurs : Tiago A. Mestre [Canada] ; Isabelle Beaulieu-Boire [Canada] ; Camila C. Aquino [Canada] ; Nicolas Phielipp [États-Unis] ; Yu Yan Poon [Canada] ; Jane P. Lui [Canada] ; Julie So [Canada] ; Susan H. Fox [Canada]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Clinical Trials, Phase II as Topic, Dopamine Agents (administration & dosage), Dopamine Agents (pharmacology), Double-Blind Method, Dyskinesias (drug therapy), Female, Humans, Levodopa (administration & dosage), Levodopa (pharmacology), Male, Middle Aged, Parkinson Disease (drug therapy), Patient Outcome Assessment.
- MESH :
- chemical , administration & dosage : Dopamine Agents, Levodopa.
- chemical , pharmacology : Dopamine Agents, Levodopa.
- drug therapy : Dyskinesias, Parkinson Disease.
- Aged, Clinical Trials, Phase II as Topic, Double-Blind Method, Female, Humans, Male, Middle Aged, Patient Outcome Assessment.
Abstract
Dyskinesia remain a significant problem in Parkinson Disease (PD). The translation process of novel drug targets for dyskinesia has proven difficult with several failures at phase III level. Determining the 'clinically important change' (CIC) for dyskinesia rating scales in phase II clinical trials may assist in optimizing drug development of new anti-dyskinetic treatments. We used a standard phase IIa acute levodopa infusion paradigm to determine for the first time the CIC for dyskinesia using the new UDysRS.
DOI: 10.1016/j.parkreldis.2015.09.044
PubMed: 26439944
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<term>Dyskinesias (drug therapy)</term>
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<front><div type="abstract" xml:lang="en">Dyskinesia remain a significant problem in Parkinson Disease (PD). The translation process of novel drug targets for dyskinesia has proven difficult with several failures at phase III level. Determining the 'clinically important change' (CIC) for dyskinesia rating scales in phase II clinical trials may assist in optimizing drug development of new anti-dyskinetic treatments. We used a standard phase IIa acute levodopa infusion paradigm to determine for the first time the CIC for dyskinesia using the new UDysRS.</div>
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