Improving outcomes of subthalamic nucleus deep brain stimulation in Parkinson's disease.
Identifieur interne : 001D13 ( Ncbi/Curation ); précédent : 001D12; suivant : 001D14Improving outcomes of subthalamic nucleus deep brain stimulation in Parkinson's disease.
Auteurs : Ausaf A. Bari [Canada] ; Alfonso Fasano [Canada] ; Renato P. Munhoz [Canada] ; Andres M. Lozano [Canada]Source :
- Expert review of neurotherapeutics [ 1744-8360 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Humans, Treatment Outcome.
Abstract
The subthalamic nucleus (STN) has been a major target of deep brain stimulation (DBS) for Parkinson's disease (PD) over the past 20 years. The benefits of DBS of the STN include: decreased motor fluctuations and bradykinesia, tremor reduction and a reduction in dopaminergic drug requirements and dyskinesias. Despite these overall positive effects, the outcomes of STN DBS can be variable, contributing to the debate over the best DBS target for PD. Here, the authors review the current practice of STN DBS and also review both the existing and emerging technologies that are likely to improve the accuracy and effectiveness of STN DBS for PD. The authors emphasize patient selection, accuracy of electrode placement within the brain and the selection of appropriate stimulation parameters to optimize clinical benefits.
DOI: 10.1586/14737175.2015.1081815
PubMed: 26377740
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pubmed:26377740Le document en format XML
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<front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) has been a major target of deep brain stimulation (DBS) for Parkinson's disease (PD) over the past 20 years. The benefits of DBS of the STN include: decreased motor fluctuations and bradykinesia, tremor reduction and a reduction in dopaminergic drug requirements and dyskinesias. Despite these overall positive effects, the outcomes of STN DBS can be variable, contributing to the debate over the best DBS target for PD. Here, the authors review the current practice of STN DBS and also review both the existing and emerging technologies that are likely to improve the accuracy and effectiveness of STN DBS for PD. The authors emphasize patient selection, accuracy of electrode placement within the brain and the selection of appropriate stimulation parameters to optimize clinical benefits.</div>
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