Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease
Identifieur interne : 001998 ( Ncbi/Curation ); précédent : 001997; suivant : 001999Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease
Auteurs : Noa Liscovitch [Israël] ; Leon French [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Expression patterns of the alpha-synuclein gene (SNCA) were studied across anatomy, development, and disease to better characterize its role in the brain. In this postmortem study, negative spatial co-expression between SNCA and 73 interferon-γ (IFN-γ) signaling genes was observed across many brain regions. Recent animal studies have demonstrated that IFN-γ induces loss of dopamine neurons and nigrostriatal degeneration. This opposing pattern between SNCA and IFN-γ signaling genes increases with age (rho = −0.78). In contrast, a meta-analysis of four microarray experiments representing 126 substantia nigra samples reveals a switch to positive co-expression in Parkinson’s disease (p<0.005). Use of genome-wide testing demonstrates this relationship is specific to SNCA (p<0.002). This change in co-expression suggests an immunomodulatory role of SNCA that may provide insight into neurodegeneration. Genes showing similar co-expression patterns have been previously linked to Alzheimer’s (ANK1) and Parkinson’s disease (UBE2E2, PCMT1, HPRT1 and RIT2).
Url:
DOI: 10.1371/journal.pone.0115029
PubMed: 25493648
PubMed Central: 4262449
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000094
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000094
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000508
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001998
Links to Exploration step
PMC:4262449Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease</title><author><name sortKey="Liscovitch, Noa" sort="Liscovitch, Noa" uniqKey="Liscovitch N" first="Noa" last="Liscovitch">Noa Liscovitch</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel</addr-line></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan</wicri:regionArea><wicri:noRegion>Ramat Gan</wicri:noRegion></affiliation></author><author><name sortKey="French, Leon" sort="French, Leon" uniqKey="French L" first="Leon" last="French">Leon French</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Rotman Research Institute, Baycrest Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Rotman Research Institute, Baycrest Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25493648</idno><idno type="pmc">4262449</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262449</idno><idno type="RBID">PMC:4262449</idno><idno type="doi">10.1371/journal.pone.0115029</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000094</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000094</idno><idno type="wicri:Area/Pmc/Curation">000094</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000094</idno><idno type="wicri:Area/Pmc/Checkpoint">000508</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000508</idno><idno type="wicri:Area/Ncbi/Merge">001998</idno><idno type="wicri:Area/Ncbi/Curation">001998</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease</title><author><name sortKey="Liscovitch, Noa" sort="Liscovitch, Noa" uniqKey="Liscovitch N" first="Noa" last="Liscovitch">Noa Liscovitch</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel</addr-line></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan</wicri:regionArea><wicri:noRegion>Ramat Gan</wicri:noRegion></affiliation></author><author><name sortKey="French, Leon" sort="French, Leon" uniqKey="French L" first="Leon" last="French">Leon French</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Rotman Research Institute, Baycrest Hospital, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Rotman Research Institute, Baycrest Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Expression patterns of the alpha-synuclein gene (SNCA) were studied across anatomy, development, and disease to better characterize its role in the brain. In this postmortem study, negative spatial co-expression between SNCA and 73 interferon-γ (IFN-γ) signaling genes was observed across many brain regions. Recent animal studies have demonstrated that IFN-γ induces loss of dopamine neurons and nigrostriatal degeneration. This opposing pattern between SNCA and IFN-γ signaling genes increases with age (rho = −0.78). In contrast, a meta-analysis of four microarray experiments representing 126 substantia nigra samples reveals a switch to positive co-expression in Parkinson’s disease (p<0.005). Use of genome-wide testing demonstrates this relationship is specific to SNCA (p<0.002). This change in co-expression suggests an immunomodulatory role of SNCA that may provide insight into neurodegeneration. Genes showing similar co-expression patterns have been previously linked to Alzheimer’s (ANK1) and Parkinson’s disease (UBE2E2, PCMT1, HPRT1 and RIT2).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Klein, C" uniqKey="Klein C">C Klein</name></author><author><name sortKey="Westenberger, A" uniqKey="Westenberger A">A Westenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keller, Mf" uniqKey="Keller M">MF Keller</name></author><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author><author><name sortKey="Bras, J" uniqKey="Bras J">J Bras</name></author><author><name sortKey="Bettella, F" uniqKey="Bettella F">F Bettella</name></author><author><name sortKey="Nicolaou, N" uniqKey="Nicolaou N">N Nicolaou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polymeropoulos, Mh" uniqKey="Polymeropoulos M">MH Polymeropoulos</name></author><author><name sortKey="Lavedan, C" uniqKey="Lavedan C">C Lavedan</name></author><author><name sortKey="Leroy, E" uniqKey="Leroy E">E Leroy</name></author><author><name sortKey="Ide, Se" uniqKey="Ide S">SE Ide</name></author><author><name sortKey="Dehejia, A" uniqKey="Dehejia A">A Dehejia</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Marques, O" uniqKey="Marques O">O Marques</name></author><author><name sortKey="Outeiro, Tf" uniqKey="Outeiro T">TF Outeiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hawrylycz, Mj" uniqKey="Hawrylycz M">MJ Hawrylycz</name></author><author><name sortKey="Lein, Es" uniqKey="Lein E">ES Lein</name></author><author><name sortKey="Guillozet Bongaarts, Al" uniqKey="Guillozet Bongaarts A">AL Guillozet-Bongaarts</name></author><author><name sortKey="Shen, Eh" uniqKey="Shen E">EH Shen</name></author><author><name sortKey="Ng, L" uniqKey="Ng L">L Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Ja" uniqKey="Miller J">JA Miller</name></author><author><name sortKey="Ding, S L" uniqKey="Ding S">S-L Ding</name></author><author><name sortKey="Sunkin, Sm" uniqKey="Sunkin S">SM Sunkin</name></author><author><name sortKey="Smith, Ka" uniqKey="Smith K">KA Smith</name></author><author><name sortKey="Ng, L" uniqKey="Ng L">L Ng</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="James, M" uniqKey="James M">M James</name></author><author><name sortKey="Middleton, F" uniqKey="Middleton F">F Middleton</name></author><author><name sortKey="Davis, Rl" uniqKey="Davis R">RL Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moran, Lb" uniqKey="Moran L">LB Moran</name></author><author><name sortKey="Duke, Dc" uniqKey="Duke D">DC Duke</name></author><author><name sortKey="Deprez, M" uniqKey="Deprez M">M Deprez</name></author><author><name sortKey="Dexter, Dt" uniqKey="Dexter D">DT Dexter</name></author><author><name sortKey="Pearce, Rkb" uniqKey="Pearce R">RKB Pearce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lesnick, Tg" uniqKey="Lesnick T">TG Lesnick</name></author><author><name sortKey="Papapetropoulos, S" uniqKey="Papapetropoulos S">S Papapetropoulos</name></author><author><name sortKey="Mash, Dc" uniqKey="Mash D">DC Mash</name></author><author><name sortKey="Ffrench Mullen, J" uniqKey="Ffrench Mullen J">J Ffrench-Mullen</name></author><author><name sortKey="Shehadeh, L" uniqKey="Shehadeh L">L Shehadeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, B" uniqKey="Zheng B">B Zheng</name></author><author><name sortKey="Liao, Z" uniqKey="Liao Z">Z Liao</name></author><author><name sortKey="Locascio, Jj" uniqKey="Locascio J">JJ Locascio</name></author><author><name sortKey="Lesniak, Ka" uniqKey="Lesniak K">KA Lesniak</name></author><author><name sortKey="Roderick, Ss" uniqKey="Roderick S">SS Roderick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scherzer, Cr" uniqKey="Scherzer C">CR Scherzer</name></author><author><name sortKey="Eklund, Ac" uniqKey="Eklund A">AC Eklund</name></author><author><name sortKey="Morse, Lj" uniqKey="Morse L">LJ Morse</name></author><author><name sortKey="Liao, Z" uniqKey="Liao Z">Z Liao</name></author><author><name sortKey="Locascio, Jj" uniqKey="Locascio J">JJ Locascio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zoubarev, A" uniqKey="Zoubarev A">A Zoubarev</name></author><author><name sortKey="Hamer, Km" uniqKey="Hamer K">KM Hamer</name></author><author><name sortKey="Keshav, Kd" uniqKey="Keshav K">KD Keshav</name></author><author><name sortKey="Mccarthy, El" uniqKey="Mccarthy E">EL McCarthy</name></author><author><name sortKey="Santos, Jrc" uniqKey="Santos J">JRC Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eden, E" uniqKey="Eden E">E Eden</name></author><author><name sortKey="Navon, R" uniqKey="Navon R">R Navon</name></author><author><name sortKey="Steinfeld, I" uniqKey="Steinfeld I">I Steinfeld</name></author><author><name sortKey="Lipson, D" uniqKey="Lipson D">D Lipson</name></author><author><name sortKey="Yakhini, Z" uniqKey="Yakhini Z">Z Yakhini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalaitzakis, Me" uniqKey="Kalaitzakis M">ME Kalaitzakis</name></author><author><name sortKey="Pearce, Rkb" uniqKey="Pearce R">RKB Pearce</name></author><author><name sortKey="Gentleman, Sm" uniqKey="Gentleman S">SM Gentleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christopher, L" uniqKey="Christopher L">L Christopher</name></author><author><name sortKey="Koshimori, Y" uniqKey="Koshimori Y">Y Koshimori</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Criaud, M" uniqKey="Criaud M">M Criaud</name></author><author><name sortKey="Strafella, Ap" uniqKey="Strafella A">AP Strafella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliver, S" uniqKey="Oliver S">S Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Ed" uniqKey="Martin E">ED Martín</name></author><author><name sortKey="Gonzalez Garcia, C" uniqKey="Gonzalez Garcia C">C González-García</name></author><author><name sortKey="Milan, M" uniqKey="Milan M">M Milán</name></author><author><name sortKey="Fari As, I" uniqKey="Fari As I">I Fariñas</name></author><author><name sortKey="Ce A, V" uniqKey="Ce A V">V Ceña</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chakrabarty, P" uniqKey="Chakrabarty P">P Chakrabarty</name></author><author><name sortKey="Ceballos Diaz, C" uniqKey="Ceballos Diaz C">C Ceballos-Diaz</name></author><author><name sortKey="Lin, W L" uniqKey="Lin W">W-L Lin</name></author><author><name sortKey="Beccard, A" uniqKey="Beccard A">A Beccard</name></author><author><name sortKey="Jansen West, K" uniqKey="Jansen West K">K Jansen-West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, J H" uniqKey="Kim J">J-H Kim</name></author><author><name sortKey="Jou, I" uniqKey="Jou I">I Jou</name></author><author><name sortKey="Joe, E H" uniqKey="Joe E">E-H Joe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumeister, Aa" uniqKey="Baumeister A">AA Baumeister</name></author><author><name sortKey="Frye, Gd" uniqKey="Frye G">GD Frye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jinnah, Ha" uniqKey="Jinnah H">HA Jinnah</name></author><author><name sortKey="Ceballos Picot, I" uniqKey="Ceballos Picot I">I Ceballos-Picot</name></author><author><name sortKey="Torres, Rj" uniqKey="Torres R">RJ Torres</name></author><author><name sortKey="Visser, Je" uniqKey="Visser J">JE Visser</name></author><author><name sortKey="Schretlen, Dj" uniqKey="Schretlen D">DJ Schretlen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ouazia, D" uniqKey="Ouazia D">D Ouazia</name></author><author><name sortKey="Levros, Lc" uniqKey="Levros L">LC Levros</name></author><author><name sortKey="Rassart, E" uniqKey="Rassart E">É Rassart</name></author><author><name sortKey="Desrosiers, Rr" uniqKey="Desrosiers R">RR Desrosiers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramsey, Cp" uniqKey="Ramsey C">CP Ramsey</name></author><author><name sortKey="Giasson, Bi" uniqKey="Giasson B">BI Giasson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pankratz, N" uniqKey="Pankratz N">N Pankratz</name></author><author><name sortKey="Beecham, Gw" uniqKey="Beecham G">GW Beecham</name></author><author><name sortKey="Destefano, Al" uniqKey="Destefano A">AL Destefano</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author><author><name sortKey="Doheny, Kf" uniqKey="Doheny K">KF Doheny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nalls, M" uniqKey="Nalls M">M Nalls</name></author><author><name sortKey="Pankratz, N" uniqKey="Pankratz N">N Pankratz</name></author><author><name sortKey="Lill, Cm" uniqKey="Lill C">CM Lill</name></author><author><name sortKey="Do, Cb" uniqKey="Do C">CB Do</name></author><author><name sortKey="Hernandez, Dg" uniqKey="Hernandez D">DG Hernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jager, Pl" uniqKey="De Jager P">PL De Jager</name></author><author><name sortKey="Srivastava, G" uniqKey="Srivastava G">G Srivastava</name></author><author><name sortKey="Lunnon, K" uniqKey="Lunnon K">K Lunnon</name></author><author><name sortKey="Burgess, J" uniqKey="Burgess J">J Burgess</name></author><author><name sortKey="Schalkwyk, Lc" uniqKey="Schalkwyk L">LC Schalkwyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lunnon, K" uniqKey="Lunnon K">K Lunnon</name></author><author><name sortKey="Smith, R" uniqKey="Smith R">R Smith</name></author><author><name sortKey="Hannon, E" uniqKey="Hannon E">E Hannon</name></author><author><name sortKey="De Jager, Pl" uniqKey="De Jager P">PL De Jager</name></author><author><name sortKey="Srivastava, G" uniqKey="Srivastava G">G Srivastava</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greene, Jg" uniqKey="Greene J">JG Greene</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Attia, M" uniqKey="Attia M">M Attia</name></author><author><name sortKey="Rachez, C" uniqKey="Rachez C">C Rachez</name></author><author><name sortKey="De Pauw, A" uniqKey="De Pauw A">A De Pauw</name></author><author><name sortKey="Avner, P" uniqKey="Avner P">P Avner</name></author><author><name sortKey="Rogner, Uc" uniqKey="Rogner U">UC Rogner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, Y" uniqKey="Cai Y">Y Cai</name></author><author><name sortKey="Jin, J" uniqKey="Jin J">J Jin</name></author><author><name sortKey="Tomomori Sato, C" uniqKey="Tomomori Sato C">C Tomomori-Sato</name></author><author><name sortKey="Sato, S" uniqKey="Sato S">S Sato</name></author><author><name sortKey="Sorokina, I" uniqKey="Sorokina I">I Sorokina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kontopoulos, E" uniqKey="Kontopoulos E">E Kontopoulos</name></author><author><name sortKey="Parvin, Jd" uniqKey="Parvin J">JD Parvin</name></author><author><name sortKey="Feany, Mb" uniqKey="Feany M">MB Feany</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kannarkat, Gt" uniqKey="Kannarkat G">GT Kannarkat</name></author><author><name sortKey="Boss, Jm" uniqKey="Boss J">JM Boss</name></author><author><name sortKey="Tansey, Mg" uniqKey="Tansey M">MG Tansey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mount, Mp" uniqKey="Mount M">MP Mount</name></author><author><name sortKey="Lira, A" uniqKey="Lira A">A Lira</name></author><author><name sortKey="Grimes, D" uniqKey="Grimes D">D Grimes</name></author><author><name sortKey="Smith, Pd" uniqKey="Smith P">PD Smith</name></author><author><name sortKey="Faucher, S" uniqKey="Faucher S">S Faucher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamza, Th" uniqKey="Hamza T">TH Hamza</name></author><author><name sortKey="Zabetian, Cp" uniqKey="Zabetian C">CP Zabetian</name></author><author><name sortKey="Tenesa, A" uniqKey="Tenesa A">A Tenesa</name></author><author><name sortKey="Laederach, A" uniqKey="Laederach A">A Laederach</name></author><author><name sortKey="Montimurro, J" uniqKey="Montimurro J">J Montimurro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, I" uniqKey="Ahmed I">I Ahmed</name></author><author><name sortKey="Tamouza, R" uniqKey="Tamouza R">R Tamouza</name></author><author><name sortKey="Delord, M" uniqKey="Delord M">M Delord</name></author><author><name sortKey="Krishnamoorthy, R" uniqKey="Krishnamoorthy R">R Krishnamoorthy</name></author><author><name sortKey="Tzourio, C" uniqKey="Tzourio C">C Tzourio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardet, A" uniqKey="Gardet A">A Gardet</name></author><author><name sortKey="Benita, Y" uniqKey="Benita Y">Y Benita</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Sands, Be" uniqKey="Sands B">BE Sands</name></author><author><name sortKey="Ballester, I" uniqKey="Ballester I">I Ballester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Powers, Km" uniqKey="Powers K">KM Powers</name></author><author><name sortKey="Kay, Dm" uniqKey="Kay D">DM Kay</name></author><author><name sortKey="Factor, S" uniqKey="Factor S">S Factor</name></author><author><name sortKey="Zabetian, Cp" uniqKey="Zabetian C">CP Zabetian</name></author><author><name sortKey="Higgins, Ds" uniqKey="Higgins D">DS Higgins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tebow, G" uniqKey="Tebow G">G Tebow</name></author><author><name sortKey="Sherrill, Dl" uniqKey="Sherrill D">DL Sherrill</name></author><author><name sortKey="Lohman, Ic" uniqKey="Lohman I">IC Lohman</name></author><author><name sortKey="Stern, Da" uniqKey="Stern D">DA Stern</name></author><author><name sortKey="Wright, Al" uniqKey="Wright A">AL Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritter, M" uniqKey="Ritter M">M Ritter</name></author><author><name sortKey="Hohenberger, K" uniqKey="Hohenberger K">K Hohenberger</name></author><author><name sortKey="Alter, P" uniqKey="Alter P">P Alter</name></author><author><name sortKey="Herzum, M" uniqKey="Herzum M">M Herzum</name></author><author><name sortKey="Tebbe, J" uniqKey="Tebbe J">J Tebbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagne, Jj" uniqKey="Gagne J">JJ Gagne</name></author><author><name sortKey="Power, Mc" uniqKey="Power M">MC Power</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dinh, K" uniqKey="Dinh K">K Dinh</name></author><author><name sortKey="Poindexter, Bj" uniqKey="Poindexter B">BJ Poindexter</name></author><author><name sortKey="Barnes, Jl" uniqKey="Barnes J">JL Barnes</name></author><author><name sortKey="Schiess, Mc" uniqKey="Schiess M">MC Schiess</name></author><author><name sortKey="Bick, Rj" uniqKey="Bick R">RJ Bick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Seo, J H" uniqKey="Seo J">J-H Seo</name></author><author><name sortKey="Suh, Y H" uniqKey="Suh Y">Y-H Suh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markopoulou, K" uniqKey="Markopoulou K">K Markopoulou</name></author><author><name sortKey="Biernacka, Jm" uniqKey="Biernacka J">JM Biernacka</name></author><author><name sortKey="Armasu, Sm" uniqKey="Armasu S">SM Armasu</name></author><author><name sortKey="Anderson, Kj" uniqKey="Anderson K">KJ Anderson</name></author><author><name sortKey="Ahlskog, Je" uniqKey="Ahlskog J">JE Ahlskog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harms, As" uniqKey="Harms A">AS Harms</name></author><author><name sortKey="Cao, S" uniqKey="Cao S">S Cao</name></author><author><name sortKey="Rowse, Al" uniqKey="Rowse A">AL Rowse</name></author><author><name sortKey="Thome, Ad" uniqKey="Thome A">AD Thome</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barcia, C" uniqKey="Barcia C">C Barcia</name></author><author><name sortKey="Ros, Cm" uniqKey="Ros C">CM Ros</name></author><author><name sortKey="Annese, V" uniqKey="Annese V">V Annese</name></author><author><name sortKey="Gomez, A" uniqKey="Gomez A">A Gomez</name></author><author><name sortKey="Ros Bernal, F" uniqKey="Ros Bernal F">F Ros-Bernal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Austin, Sa" uniqKey="Austin S">SA Austin</name></author><author><name sortKey="Rojanathammanee, L" uniqKey="Rojanathammanee L">L Rojanathammanee</name></author><author><name sortKey="Golovko, My" uniqKey="Golovko M">MY Golovko</name></author><author><name sortKey="Murphy, Ej" uniqKey="Murphy E">EJ Murphy</name></author><author><name sortKey="Combs, Ck" uniqKey="Combs C">CK Combs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Austin, Sa" uniqKey="Austin S">SA Austin</name></author><author><name sortKey="Floden, Am" uniqKey="Floden A">AM Floden</name></author><author><name sortKey="Murphy, Ej" uniqKey="Murphy E">EJ Murphy</name></author><author><name sortKey="Combs, Ck" uniqKey="Combs C">CK Combs</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001998 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001998 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:4262449
|texte= Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:25493648" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |