Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice
Identifieur interne : 001728 ( Ncbi/Curation ); précédent : 001727; suivant : 001729Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice
Auteurs : Gonzalo Sanchez [Canada] ; Rafael K. Varaschin [Canada] ; Hansruedi Büeler [République populaire de Chine] ; Paul C. Marcogliese [Canada] ; David S. Park [Canada] ; Louis-Eric Trudeau [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Parkinson's disease (PD) is one of the most prevalent neurodegenerative brain diseases; it is accompanied by extensive loss of dopamine (DA) neurons of the substantia nigra that project to the putamen, leading to impaired motor functions. Several genes have been associated with hereditary forms of the disease and transgenic mice have been developed by a number of groups to produce animal models of PD and to explore the basic functions of these genes. Surprisingly, most of the various mouse lines generated such as
Url:
DOI: 10.1371/journal.pone.0094826
PubMed: 24733019
PubMed Central: 3986353
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PMC:3986353Le document en format XML
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Knockout, <italic>Pink1</italic>
Knockout, <italic>DJ-1</italic>
Knockout and LRRK2 R1441G Transgenic Mice</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Unaltered Striatal Dopamine Release Levels in Young <italic>Parkin</italic>
Knockout, <italic>Pink1</italic>
Knockout, <italic>DJ-1</italic>
Knockout and LRRK2 R1441G Transgenic Mice</title>
<author><name sortKey="Sanchez, Gonzalo" sort="Sanchez, Gonzalo" uniqKey="Sanchez G" first="Gonzalo" last="Sanchez">Gonzalo Sanchez</name>
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<author><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name>
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<author><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name>
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<wicri:regionArea>Departments of pharmacology and neurosciences, Central Nervous System Research Group, Faculty of Medicine, Université de Montréal, Montreal</wicri:regionArea>
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<front><div type="abstract" xml:lang="en"><p>Parkinson's disease (PD) is one of the most prevalent neurodegenerative brain diseases; it is accompanied by extensive loss of dopamine (DA) neurons of the substantia nigra that project to the putamen, leading to impaired motor functions. Several genes have been associated with hereditary forms of the disease and transgenic mice have been developed by a number of groups to produce animal models of PD and to explore the basic functions of these genes. Surprisingly, most of the various mouse lines generated such as <italic>Parkin</italic>
KO, <italic>Pink1</italic>
KO, <italic>DJ-1</italic>
KO and <italic>LRRK2</italic>
transgenic have been reported to lack degeneration of nigral DA neuron, one of the hallmarks of PD. However, modest impairments of motor behavior have been reported, suggesting the possibility that the models recapitulate at least some of the early stages of PD, including early dysfunction of DA axon terminals. To further evaluate this possibility, here we provide for the first time a systematic comparison of DA release in four different mouse lines, examined at a young age range, prior to potential age-dependent compensations. Using fast scan cyclic voltammetry in striatal sections prepared from young, 6–8 weeks old mice, we examined sub-second DA overflow evoked by single pulses and action potential trains. Unexpectedly, none of the models displayed any dysfunction of DA overflow or reuptake. These results, compatible with the lack of DA neuron loss in these models, suggest that molecular dysfunctions caused by the absence or mutation of these individual genes are not sufficient to perturb the function and survival of mouse DA neurons.</p>
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