Long-term safety of rivastigmine in parkinson disease dementia: an open-label, randomized study.
Identifieur interne : 001664 ( Ncbi/Curation ); précédent : 001663; suivant : 001665Long-term safety of rivastigmine in parkinson disease dementia: an open-label, randomized study.
Auteurs : Murat Emre [États-Unis] ; Werner Poewe ; Peter Paul De Deyn ; Paolo Barone ; Jaime Kulisevsky ; Emmanuelle Pourcher ; Teus Van Laar ; Alexander Storch ; Federico Micheli ; David Burn ; Frank Durif ; Rajesh Pahwa ; Francesca Callegari ; Nadia Tenenbaum ; Christine StrohmaierSource :
- Clinical neuropharmacology [ 1537-162X ]
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Dementia (drug therapy), Dementia (etiology), Drug Carriers, Drug Delivery Systems, Female, Humans, International Cooperation, Longitudinal Studies, Male, Middle Aged, Neuroprotective Agents (therapeutic use), Outcome Assessment (Health Care), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Patient Compliance, Phenylcarbamates (therapeutic use), Quality of Life, Rivastigmine, Time Factors, Transdermal Patch, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Neuroprotective Agents, Phenylcarbamates.
- chemical : Drug Carriers, Rivastigmine.
- complications : Parkinson Disease.
- drug therapy : Dementia, Parkinson Disease.
- etiology : Dementia.
- psychology : Parkinson Disease.
- Aged, Aged, 80 and over, Analysis of Variance, Drug Delivery Systems, Female, Humans, International Cooperation, Longitudinal Studies, Male, Middle Aged, Outcome Assessment (Health Care), Patient Compliance, Quality of Life, Time Factors, Transdermal Patch, Treatment Outcome.
Abstract
This study investigated the long-term safety of rivastigmine (12 mg/d capsules, 9.5 mg/24 h patch) and effects on motor symptoms in patients with mild-to-moderately severe Parkinson disease dementia.
DOI: 10.1097/WNF.0000000000000010
PubMed: 24434526
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<wicri:cityArea>*Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; †Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; ‡Middelheim Hospital, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; §Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ║Neurodegenerative Diseases Centre, Department of Medicine, University of Salerno, Italy; ¶Department of Neurology, Movement Disorders Unit, Hospital de Sant Pau (IIB-Sant Pau) and CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain; #Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte Anne, Québec, Canada; **Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany; ††Department of Neurology, Hospital de Clinicas, University of Buenos Aires, Argentina; ‡‡Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; §§Service De Neurologie CHU, Clermont-Ferrand, France; ║║Parkinson's Disease and Movement Disorder Center, University of Kansas Medical Center, Kansas City, KS; ¶¶Novartis Pharma AG, Basel, Switzerland; and ##Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:affiliation>*Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; †Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; ‡Middelheim Hospital, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; §Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ║Neurodegenerative Diseases Centre, Department of Medicine, University of Salerno, Italy; ¶Department of Neurology, Movement Disorders Unit, Hospital de Sant Pau (IIB-Sant Pau) and CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain; #Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte Anne, Québec, Canada; **Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany; ††Department of Neurology, Hospital de Clinicas, University of Buenos Aires, Argentina; ‡‡Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; §§Service De Neurologie CHU, Clermont-Ferrand, France; ║║Parkinson's Disease and Movement Disorder Center, University of Kansas Medical Center, Kansas City, KS; ¶¶Novartis Pharma AG, Basel, Switzerland; and ##Novartis Pharmaceuticals Corporation, East Hanover, NJ.</nlm:affiliation>
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<wicri:cityArea>*Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; †Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; ‡Middelheim Hospital, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; §Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ║Neurodegenerative Diseases Centre, Department of Medicine, University of Salerno, Italy; ¶Department of Neurology, Movement Disorders Unit, Hospital de Sant Pau (IIB-Sant Pau) and CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain; #Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte Anne, Québec, Canada; **Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany; ††Department of Neurology, Hospital de Clinicas, University of Buenos Aires, Argentina; ‡‡Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; §§Service De Neurologie CHU, Clermont-Ferrand, France; ║║Parkinson's Disease and Movement Disorder Center, University of Kansas Medical Center, Kansas City, KS; ¶¶Novartis Pharma AG, Basel, Switzerland; and ##Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea>
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<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Dementia (drug therapy)</term>
<term>Dementia (etiology)</term>
<term>Drug Carriers</term>
<term>Drug Delivery Systems</term>
<term>Female</term>
<term>Humans</term>
<term>International Cooperation</term>
<term>Longitudinal Studies</term>
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<term>Middle Aged</term>
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<term>Outcome Assessment (Health Care)</term>
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<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (psychology)</term>
<term>Patient Compliance</term>
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<term>Rivastigmine</term>
<term>Time Factors</term>
<term>Transdermal Patch</term>
<term>Treatment Outcome</term>
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<term>Rivastigmine</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dementia</term>
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<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Drug Delivery Systems</term>
<term>Female</term>
<term>Humans</term>
<term>International Cooperation</term>
<term>Longitudinal Studies</term>
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<term>Middle Aged</term>
<term>Outcome Assessment (Health Care)</term>
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<front><div type="abstract" xml:lang="en">This study investigated the long-term safety of rivastigmine (12 mg/d capsules, 9.5 mg/24 h patch) and effects on motor symptoms in patients with mild-to-moderately severe Parkinson disease dementia.</div>
</front>
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