The prion hypothesis in Parkinson's disease: Braak to the future
Identifieur interne : 001619 ( Ncbi/Curation ); précédent : 001618; suivant : 001620The prion hypothesis in Parkinson's disease: Braak to the future
Auteurs : Naomi P. Visanji [Canada] ; Patricia L. Brooks [Canada] ; Lili-Naz Hazrati [Canada] ; Anthony E. Lang [Canada]Source :
- Acta Neuropathologica Communications [ 2051-5960 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Prions.
- etiology : Parkinson Disease.
- pathology : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Animals, Humans, Models, Neurological, Severity of Illness Index.
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disorder typified by the presence of intraneuronal inclusions containing aggregated alpha synuclein (αsyn). The progression of parkinsonian pathology and clinical phenotype has been broadly demonstrated to follow a specific pattern, most notably described by Braak and colleagues. In more recent times it has been hypothesized that αsyn itself may be a critical factor in mediating transmission of disease pathology from one brain area to another. Here we investigate the growing body of evidence demonstrating the ability of αsyn to spread transcellularly and induce pathological aggregation affecting neurons by permissive templating and provide a critical analysis of some irregularities in the hypothesis that the progression of PD pathology may be mediated by such a prion-like process. Finally we discuss some key questions that remain unanswered which are vital to determining the potential contribution of a prion-like process to the pathogenesis of PD.
Url:
DOI: 10.1186/2051-5960-1-2
PubMed: 24252164
PubMed Central: 3776210
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PMC:3776210Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder typified by the presence of intraneuronal inclusions containing aggregated alpha synuclein (αsyn). The progression of parkinsonian pathology and clinical phenotype has been broadly demonstrated to follow a specific pattern, most notably described by Braak and colleagues. In more recent times it has been hypothesized that αsyn itself may be a critical factor in mediating transmission of disease pathology from one brain area to another. Here we investigate the growing body of evidence demonstrating the ability of αsyn to spread transcellularly and induce pathological aggregation affecting neurons by permissive templating and provide a critical analysis of some irregularities in the hypothesis that the progression of PD pathology may be mediated by such a prion-like process. Finally we discuss some key questions that remain unanswered which are vital to determining the potential contribution of a prion-like process to the pathogenesis of PD.</p>
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