A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease
Identifieur interne : 001119 ( Ncbi/Curation ); précédent : 001118; suivant : 001120A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease
Auteurs : I. H. Richard ; M. P. Mcdermott ; R. Kurlan ; J. M. Lyness ; P. G. Como ; N. Pearson ; S. A. Factor ; J. Juncos ; C. Serrano Ramos ; M. Brodsky ; C. Manning ; L. Marsh ; L. Shulman ; H. H. Fernandez ; K. J. Black ; M. Panisset ; C. W. Christine ; W. Jiang ; C. Singer ; S. Horn ; R. Pfeiffer ; D. Rottenberg ; J. Slevin ; L. Elmer ; D. Press ; H. C. Hyson ; W. McdonaldSource :
- Neurology [ 0028-3878 ] ; 2012.
Abstract
To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI) in the treatment of depression in Parkinson disease (PD).
A total of 115 subjects with PD were enrolled at 20 sites. Subjects were randomized to receive an SSRI (paroxetine; n = 42), an SNRI (venlafaxine extended release [XR]; n = 34), or placebo (n = 39). Subjects met
Treatment effects (relative to placebo), expressed as mean 12-week reductions in HAM-D score, were 6.2 points (97.5% confidence interval [CI] 2.2 to 10.3,
Both paroxetine and venlafaxine XR significantly improved depression in subjects with PD. Both medications were generally safe and well tolerated and did not worsen motor function.
This study provides Class I evidence that paroxetine and venlafaxine XR are effective in treating depression in patients with PD.
Url:
DOI: 10.1212/WNL.0b013e3182516244
PubMed: 22496199
PubMed Central: 3324323
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Pearson</name></author><author><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S. A." last="Factor">S. A. Factor</name></author><author><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J." last="Juncos">J. Juncos</name></author><author><name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C." last="Serrano Ramos">C. Serrano Ramos</name></author><author><name sortKey="Brodsky, M" sort="Brodsky, M" uniqKey="Brodsky M" first="M." last="Brodsky">M. Brodsky</name></author><author><name sortKey="Manning, C" sort="Manning, C" uniqKey="Manning C" first="C." last="Manning">C. Manning</name></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name></author><author><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L." last="Shulman">L. 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H." last="Richard">I. H. Richard</name></author><author><name sortKey="Mcdermott, M P" sort="Mcdermott, M P" uniqKey="Mcdermott M" first="M. P." last="Mcdermott">M. P. Mcdermott</name></author><author><name sortKey="Kurlan, R" sort="Kurlan, R" uniqKey="Kurlan R" first="R." last="Kurlan">R. Kurlan</name></author><author><name sortKey="Lyness, J M" sort="Lyness, J M" uniqKey="Lyness J" first="J. M." last="Lyness">J. M. Lyness</name></author><author><name sortKey="Como, P G" sort="Como, P G" uniqKey="Como P" first="P. G." last="Como">P. G. Como</name></author><author><name sortKey="Pearson, N" sort="Pearson, N" uniqKey="Pearson N" first="N." last="Pearson">N. Pearson</name></author><author><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S. A." last="Factor">S. A. Factor</name></author><author><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J." last="Juncos">J. Juncos</name></author><author><name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C." last="Serrano Ramos">C. Serrano Ramos</name></author><author><name sortKey="Brodsky, M" sort="Brodsky, M" uniqKey="Brodsky M" first="M." last="Brodsky">M. Brodsky</name></author><author><name sortKey="Manning, C" sort="Manning, C" uniqKey="Manning C" first="C." last="Manning">C. Manning</name></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name></author><author><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L." last="Shulman">L. Shulman</name></author><author><name sortKey="Fernandez, H H" sort="Fernandez, H H" uniqKey="Fernandez H" first="H. H." last="Fernandez">H. H. Fernandez</name></author><author><name sortKey="Black, K J" sort="Black, K J" uniqKey="Black K" first="K. J." last="Black">K. J. Black</name></author><author><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M." last="Panisset">M. Panisset</name></author><author><name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C. W." last="Christine">C. W. Christine</name></author><author><name sortKey="Jiang, W" sort="Jiang, W" uniqKey="Jiang W" first="W." last="Jiang">W. Jiang</name></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name></author><author><name sortKey="Horn, S" sort="Horn, S" uniqKey="Horn S" first="S." last="Horn">S. Horn</name></author><author><name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R." last="Pfeiffer">R. Pfeiffer</name></author><author><name sortKey="Rottenberg, D" sort="Rottenberg, D" uniqKey="Rottenberg D" first="D." last="Rottenberg">D. Rottenberg</name></author><author><name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J." last="Slevin">J. Slevin</name></author><author><name sortKey="Elmer, L" sort="Elmer, L" uniqKey="Elmer L" first="L." last="Elmer">L. Elmer</name></author><author><name sortKey="Press, D" sort="Press, D" uniqKey="Press D" first="D." last="Press">D. Press</name></author><author><name sortKey="Hyson, H C" sort="Hyson, H C" uniqKey="Hyson H" first="H. C." last="Hyson">H. C. Hyson</name></author><author><name sortKey="Mcdonald, W" sort="Mcdonald, W" uniqKey="Mcdonald W" first="W." last="Mcdonald">W. Mcdonald</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI) in the treatment of depression in Parkinson disease (PD).</p></sec><sec><title>Methods:</title><p>A total of 115 subjects with PD were enrolled at 20 sites. Subjects were randomized to receive an SSRI (paroxetine; n = 42), an SNRI (venlafaxine extended release [XR]; n = 34), or placebo (n = 39). Subjects met <italic>DSM-IV</italic> criteria for a depressive disorder, or operationally defined subsyndromal depression, and scored >12 on the first 17 items of the Hamilton Rating Scale for Depression (HAM-D). Subjects were followed for 12 weeks (6-week dosage adjustment, 6-week maintenance). Maximum daily dosages were 40 mg for paroxetine and 225 mg for venlafaxine XR. The primary outcome measure was change in the HAM-D score from baseline to week 12.</p></sec><sec><title>Results:</title><p>Treatment effects (relative to placebo), expressed as mean 12-week reductions in HAM-D score, were 6.2 points (97.5% confidence interval [CI] 2.2 to 10.3, <italic>p</italic> = 0.0007) in the paroxetine group and 4.2 points (97.5% CI 0.1 to 8.4, <italic>p</italic> = 0.02) in the venlafaxine XR group. No treatment effects were seen on motor function.</p></sec><sec><title>Conclusions:</title><p>Both paroxetine and venlafaxine XR significantly improved depression in subjects with PD. Both medications were generally safe and well tolerated and did not worsen motor function.</p></sec><sec><title>Classification of Evidence:</title><p>This study provides Class I evidence that paroxetine and venlafaxine XR are effective in treating depression in patients with PD.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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