The Course of Depressive Symptoms in Early Parkinson’s Disease
Identifieur interne : 000A74 ( Ncbi/Curation ); précédent : 000A73; suivant : 000A75The Course of Depressive Symptoms in Early Parkinson’s Disease
Auteurs : B. Ravina [États-Unis] ; J. Elm [États-Unis] ; R. Camicioli [Canada] ; P. G. Como [États-Unis] ; L. Marsh [États-Unis] ; Joseph Jankovic [États-Unis] ; D. Weintraub [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2009.
Abstract
Little is known about the course of depressive symptoms in Parkinson’s disease (PD).
We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12–18 months. We measured depressive symptoms with the 15-item Geriatric Depression Scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms.
114 of 413 (27.6%) subjects screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS≥10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83 to 0.92).
Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.
Url:
DOI: 10.1002/mds.22572
PubMed: 19412939
PubMed Central: 2788307
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000427
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000427
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A86
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000A74
Links to Exploration step
PMC:2788307Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Course of Depressive Symptoms in Early Parkinson’s Disease</title><author><name sortKey="Ravina, B" sort="Ravina, B" uniqKey="Ravina B" first="B." last="Ravina">B. Ravina</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Elm, J" sort="Elm, J" uniqKey="Elm J" first="J." last="Elm">J. Elm</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistics, Medical University of South Carolina, Charleston, SC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Biostatistics, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Camicioli, R" sort="Camicioli, R" uniqKey="Camicioli R" first="R." last="Camicioli">R. Camicioli</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, University of Alberta, Edmonton, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, University of Alberta, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Como, P G" sort="Como, P G" uniqKey="Como P" first="P. G." last="Como">P. G. Como</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name><affiliation wicri:level="2"><nlm:aff id="A4">Departments of Psychiatry and Neurology, Johns Hopkins University, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J." last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Baylor College of Medicine, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Weintraub, D" sort="Weintraub, D" uniqKey="Weintraub D" first="D." last="Weintraub">D. Weintraub</name><affiliation wicri:level="2"><nlm:aff id="A6">Departments of Psychiatry and Neurology, University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19412939</idno><idno type="pmc">2788307</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788307</idno><idno type="RBID">PMC:2788307</idno><idno type="doi">10.1002/mds.22572</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000427</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000427</idno><idno type="wicri:Area/Pmc/Curation">000427</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000427</idno><idno type="wicri:Area/Pmc/Checkpoint">000A86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A86</idno><idno type="wicri:Area/Ncbi/Merge">000A74</idno><idno type="wicri:Area/Ncbi/Curation">000A74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Course of Depressive Symptoms in Early Parkinson’s Disease</title><author><name sortKey="Ravina, B" sort="Ravina, B" uniqKey="Ravina B" first="B." last="Ravina">B. Ravina</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Elm, J" sort="Elm, J" uniqKey="Elm J" first="J." last="Elm">J. Elm</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistics, Medical University of South Carolina, Charleston, SC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Biostatistics, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Camicioli, R" sort="Camicioli, R" uniqKey="Camicioli R" first="R." last="Camicioli">R. Camicioli</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, University of Alberta, Edmonton, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, University of Alberta, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Como, P G" sort="Como, P G" uniqKey="Como P" first="P. G." last="Como">P. G. Como</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name><affiliation wicri:level="2"><nlm:aff id="A4">Departments of Psychiatry and Neurology, Johns Hopkins University, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J." last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Baylor College of Medicine, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Weintraub, D" sort="Weintraub, D" uniqKey="Weintraub D" first="D." last="Weintraub">D. Weintraub</name><affiliation wicri:level="2"><nlm:aff id="A6">Departments of Psychiatry and Neurology, University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Departments of Psychiatry and Neurology, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Little is known about the course of depressive symptoms in Parkinson’s disease (PD).</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12–18 months. We measured depressive symptoms with the 15-item Geriatric Depression Scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms.</p></sec><sec id="S3"><title>Results</title><p id="P3">114 of 413 (27.6%) subjects screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS≥10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83 to 0.92).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A74 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000A74 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:2788307
|texte= The Course of Depressive Symptoms in Early Parkinson’s Disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:19412939" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |