Absence of cognitive deficits following deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease.
Identifieur interne : 000899 ( Ncbi/Curation ); précédent : 000898; suivant : 000900Absence of cognitive deficits following deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease.
Auteurs : Maria Fraraccio [Canada] ; Alain Ptito ; Abbas Sadikot ; Michel Panisset ; Alain DagherSource :
- Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists [ 1873-5843 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Cognition Disorders (physiopathology), Cohort Studies, Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (psychology), Educational Status, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (therapy), Subthalamic Nucleus, Task Performance and Analysis.
- MESH :
- adverse effects : Deep Brain Stimulation.
- diagnosis : Cognition Disorders.
- etiology : Cognition Disorders.
- physiopathology : Cognition Disorders, Parkinson Disease.
- psychology : Deep Brain Stimulation, Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Cohort Studies, Educational Status, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Subthalamic Nucleus, Task Performance and Analysis.
Abstract
Electrical stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. While most patients who undergo this procedure do not appear to suffer behavioral side effects, a minority experience cognitive or emotional deficits, and longitudinal studies have reported declines; however, the measures of cognitive function used have been limited. One explanation for the possible disturbance of cognitive functions is that electrical stimulation of the subthalamic nucleus disrupts the normal flow of information within cortico-striatal loops involving prefrontal, associative, or limbic cortex. We wished to assess the effect of high frequency electrical stimulation of the subthalamic nucleus in Parkinson's disease patients while they performed a comprehensive neuropsychological test battery. We selected cognitive tasks known to test the function of different cortical areas, including tests of executive function, cognitive flexibility, attention, memory, language and visual perception. Patients were tested on two separate days, with the stimulators turned on or off. Test scores were also compared to preoperative performance. In our sample of 15 patients without dementia or major depression there was no deterioration on any cognitive test as a result of stimulation. We conclude that electrical stimulation of the motor subthalamic nucleus does not cause appreciable declines in cognitive function in well-selected patients.
DOI: 10.1016/j.acn.2008.02.001
PubMed: 18394859
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Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Deep Brain Stimulation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Educational Status</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Subthalamic Nucleus</term><term>Task Performance and Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electrical stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. While most patients who undergo this procedure do not appear to suffer behavioral side effects, a minority experience cognitive or emotional deficits, and longitudinal studies have reported declines; however, the measures of cognitive function used have been limited. One explanation for the possible disturbance of cognitive functions is that electrical stimulation of the subthalamic nucleus disrupts the normal flow of information within cortico-striatal loops involving prefrontal, associative, or limbic cortex. We wished to assess the effect of high frequency electrical stimulation of the subthalamic nucleus in Parkinson's disease patients while they performed a comprehensive neuropsychological test battery. We selected cognitive tasks known to test the function of different cortical areas, including tests of executive function, cognitive flexibility, attention, memory, language and visual perception. Patients were tested on two separate days, with the stimulators turned on or off. Test scores were also compared to preoperative performance. In our sample of 15 patients without dementia or major depression there was no deterioration on any cognitive test as a result of stimulation. We conclude that electrical stimulation of the motor subthalamic nucleus does not cause appreciable declines in cognitive function in well-selected patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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