Neurophysiologic aspects of deep brain stimulation.
Identifieur interne : 000143 ( Ncbi/Curation ); précédent : 000142; suivant : 000144Neurophysiologic aspects of deep brain stimulation.
Auteurs : P. Ashby [Canada] ; J C RothwellSource :
- Neurology [ 0028-3878 ] ; 2000.
English descriptors
- KwdEn :
- MESH :
- physiopathology : Parkinson Disease, Tremor, Ventral Thalamic Nuclei.
- therapy : Parkinson Disease, Tremor.
- Electric Stimulation Therapy, Humans.
Abstract
Implanting electrodes for deep brain stimulation (DBS) allows performance of a number of different neurophysiologic studies. Before definitive internalization of the device, recording and stimulation through the electrodes is possible. Stimulation of the globus pallidum produced a mixture of excitation and inhibition of ongoing muscle activity. The excitatory response is probably produced by activation of the large-diameter fibers of the corticospinal tract. Stimulation of the thalamus is mainly associated with EMG inhibition. These findings indicate that the effect of stimulation may vary in different targets and that the mechanism of action of DBS is heterogeneous. A different type of study concerns those undertaken after chronic DBS of the subthalamic nucleus (STN) and globus pallidum internum (GPi) in parkinsonian patients. Cortical mechanisms subserving movement preparation and execution have been assessed. The main findings were that stimulation had a more prominent effect on execution than on preparation and that this was greater in patients treated with STN DBS than GPi DBS.
PubMed: 11188969
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001672
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001672
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001672
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000143
Links to Exploration step
pubmed:11188969Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neurophysiologic aspects of deep brain stimulation.</title>
<author><name sortKey="Ashby, P" sort="Ashby, P" uniqKey="Ashby P" first="P" last="Ashby">P. Ashby</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Neurophysiology Service, The Toronto Hospital, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Clinical Neurophysiology Service, The Toronto Hospital, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J C" last="Rothwell">J C Rothwell</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2000">2000</date>
<idno type="RBID">pubmed:11188969</idno>
<idno type="pmid">11188969</idno>
<idno type="wicri:Area/PubMed/Corpus">001672</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001672</idno>
<idno type="wicri:Area/PubMed/Curation">001672</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001672</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001672</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001672</idno>
<idno type="wicri:Area/Ncbi/Merge">000143</idno>
<idno type="wicri:Area/Ncbi/Curation">000143</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Neurophysiologic aspects of deep brain stimulation.</title>
<author><name sortKey="Ashby, P" sort="Ashby, P" uniqKey="Ashby P" first="P" last="Ashby">P. Ashby</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Neurophysiology Service, The Toronto Hospital, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Clinical Neurophysiology Service, The Toronto Hospital, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J C" last="Rothwell">J C Rothwell</name>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Electric Stimulation Therapy</term>
<term>Humans</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Tremor (physiopathology)</term>
<term>Tremor (therapy)</term>
<term>Ventral Thalamic Nuclei (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Tremor</term>
<term>Ventral Thalamic Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Electric Stimulation Therapy</term>
<term>Humans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Implanting electrodes for deep brain stimulation (DBS) allows performance of a number of different neurophysiologic studies. Before definitive internalization of the device, recording and stimulation through the electrodes is possible. Stimulation of the globus pallidum produced a mixture of excitation and inhibition of ongoing muscle activity. The excitatory response is probably produced by activation of the large-diameter fibers of the corticospinal tract. Stimulation of the thalamus is mainly associated with EMG inhibition. These findings indicate that the effect of stimulation may vary in different targets and that the mechanism of action of DBS is heterogeneous. A different type of study concerns those undertaken after chronic DBS of the subthalamic nucleus (STN) and globus pallidum internum (GPi) in parkinsonian patients. Cortical mechanisms subserving movement preparation and execution have been assessed. The main findings were that stimulation had a more prominent effect on execution than on preparation and that this was greater in patients treated with STN DBS than GPi DBS.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000143 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000143 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:11188969 |texte= Neurophysiologic aspects of deep brain stimulation. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:11188969" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |