Positron emission tomography in manganese intoxication.
Identifieur interne : 001865 ( Ncbi/Checkpoint ); précédent : 001864; suivant : 001866Positron emission tomography in manganese intoxication.
Auteurs : E C Wolters [Canada] ; C C Huang ; C. Clark ; R F Peppard ; J. Okada ; N S Chu ; M J Adam ; T J Ruth ; D. Li ; D B CalneSource :
- Annals of neurology [ 0364-5134 ] ; 1989.
English descriptors
- KwdEn :
- Adult, Brain (metabolism), Brain (pathology), Chronic Disease, Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (pharmacokinetics), Humans, Magnetic Resonance Imaging, Manganese Poisoning, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (diagnosis), Parkinson Disease, Secondary (diagnostic imaging), Tomography, Emission-Computed.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemically induced : Parkinson Disease, Secondary.
- diagnosis : Parkinson Disease, Secondary.
- diagnostic imaging : Parkinson Disease, Secondary.
- metabolism : Brain.
- pathology : Brain.
- chemical , pharmacokinetics : Dihydroxyphenylalanine.
- Adult, Chronic Disease, Humans, Magnetic Resonance Imaging, Manganese Poisoning, Tomography, Emission-Computed.
Abstract
We employed 6-fluorodopa to study the integrity of the nigrostriatal dopaminergic projection by positron emission tomography in 4 subjects with clinical features of mild parkinsonism caused by exposure to manganese. The 6-fluorodopa scans were normal. This finding suggests that in early manganism sufficient to cause parkinsonian deficits, damage may occur in pathways postsynaptic to the nigrostriatal system, probably involving striatal or pallidal neurons. Fluorodeoxyglucose scans showed decreased cortical glucose metabolism, the significance of which is discussed.
DOI: 10.1002/ana.410260510
PubMed: 2510588
Affiliations:
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pubmed:2510588Le document en format XML
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Clark</name></author><author><name sortKey="Peppard, R F" sort="Peppard, R F" uniqKey="Peppard R" first="R F" last="Peppard">R F Peppard</name></author><author><name sortKey="Okada, J" sort="Okada, J" uniqKey="Okada J" first="J" last="Okada">J. Okada</name></author><author><name sortKey="Chu, N S" sort="Chu, N S" uniqKey="Chu N" first="N S" last="Chu">N S Chu</name></author><author><name sortKey="Adam, M J" sort="Adam, M J" uniqKey="Adam M" first="M J" last="Adam">M J Adam</name></author><author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T J" last="Ruth">T J Ruth</name></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D" last="Li">D. Li</name></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2510588</idno><idno type="pmid">2510588</idno><idno type="doi">10.1002/ana.410260510</idno><idno type="wicri:Area/PubMed/Corpus">001C10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C10</idno><idno type="wicri:Area/PubMed/Curation">001C10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C10</idno><idno type="wicri:Area/PubMed/Checkpoint">001C10</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C10</idno><idno type="wicri:Area/Ncbi/Merge">001865</idno><idno type="wicri:Area/Ncbi/Curation">001865</idno><idno type="wicri:Area/Ncbi/Checkpoint">001865</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Positron emission tomography in manganese intoxication.</title><author><name sortKey="Wolters, E C" sort="Wolters, E C" uniqKey="Wolters E" first="E C" last="Wolters">E C Wolters</name><affiliation wicri:level="1"><nlm:affiliation>Belzberg Laboratory of Clinical Neuroscience, UBC Health Sciences Centre Hospital, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Belzberg Laboratory of Clinical Neuroscience, UBC Health Sciences Centre Hospital, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Huang, C C" sort="Huang, C C" uniqKey="Huang C" first="C C" last="Huang">C C Huang</name></author><author><name sortKey="Clark, C" sort="Clark, C" uniqKey="Clark C" first="C" last="Clark">C. Clark</name></author><author><name sortKey="Peppard, R F" sort="Peppard, R F" uniqKey="Peppard R" first="R F" last="Peppard">R F Peppard</name></author><author><name sortKey="Okada, J" sort="Okada, J" uniqKey="Okada J" first="J" last="Okada">J. Okada</name></author><author><name sortKey="Chu, N S" sort="Chu, N S" uniqKey="Chu N" first="N S" last="Chu">N S Chu</name></author><author><name sortKey="Adam, M J" sort="Adam, M J" uniqKey="Adam M" first="M J" last="Adam">M J Adam</name></author><author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T J" last="Ruth">T J Ruth</name></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D" last="Li">D. Li</name></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Chronic Disease</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (pharmacokinetics)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Manganese Poisoning</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (diagnosis)</term><term>Parkinson Disease, Secondary (diagnostic imaging)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Chronic Disease</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Manganese Poisoning</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We employed 6-fluorodopa to study the integrity of the nigrostriatal dopaminergic projection by positron emission tomography in 4 subjects with clinical features of mild parkinsonism caused by exposure to manganese. The 6-fluorodopa scans were normal. This finding suggests that in early manganism sufficient to cause parkinsonian deficits, damage may occur in pathways postsynaptic to the nigrostriatal system, probably involving striatal or pallidal neurons. Fluorodeoxyglucose scans showed decreased cortical glucose metabolism, the significance of which is discussed.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Adam, M J" sort="Adam, M J" uniqKey="Adam M" first="M J" last="Adam">M J Adam</name><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name><name sortKey="Chu, N S" sort="Chu, N S" uniqKey="Chu N" first="N S" last="Chu">N S Chu</name><name sortKey="Clark, C" sort="Clark, C" uniqKey="Clark C" first="C" last="Clark">C. Clark</name><name sortKey="Huang, C C" sort="Huang, C C" uniqKey="Huang C" first="C C" last="Huang">C C Huang</name><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D" last="Li">D. Li</name><name sortKey="Okada, J" sort="Okada, J" uniqKey="Okada J" first="J" last="Okada">J. Okada</name><name sortKey="Peppard, R F" sort="Peppard, R F" uniqKey="Peppard R" first="R F" last="Peppard">R F Peppard</name><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T J" last="Ruth">T J Ruth</name></noCountry><country name="Canada"><noRegion><name sortKey="Wolters, E C" sort="Wolters, E C" uniqKey="Wolters E" first="E C" last="Wolters">E C Wolters</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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