The effect of dietary protein on the efficacy of L-dopa: a double-blind study.
Identifieur interne : 001798 ( Ncbi/Checkpoint ); précédent : 001797; suivant : 001799The effect of dietary protein on the efficacy of L-dopa: a double-blind study.
Auteurs : J K Tsui [Canada] ; S. Ross ; K. Poulin ; J. Douglas ; D. Postnikoff ; S. Calne ; W. Woodward ; D B CalneSource :
- Neurology [ 0028-3878 ] ; 1989.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Bromocriptine (therapeutic use), Carbidopa (therapeutic use), Clinical Trials as Topic, Dietary Proteins, Double-Blind Method, Drug Combinations (therapeutic use), Drug Therapy, Combination, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (diet therapy), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Random Allocation, Selegiline (therapeutic use).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Bromocriptine, Carbidopa, Drug Combinations, Levodopa, Selegiline.
- diet therapy : Parkinson Disease.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Clinical Trials as Topic, Dietary Proteins, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Random Allocation.
Abstract
We randomly placed 10 parkinsonian patients on high- and low-protein diets that tasted and looked alike, each for 1 week. All patients were taking L-dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged. A "blind" physician recorded the modified Columbia scores, objective measurements of rigidity, movement velocity, and pegboard tests three times a day for 5 days during each week. The patients recorded fluctuations hour to hour. We measured serial blood L-dopa levels on day 4 of each week. Performance was significantly better while the patients were on low-protein diets. These results did not correlate with blood L-dopa levels, which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of "off" hours. Thus, high dietary protein probably affects the efficacy of L-dopa at a central level.
PubMed: 2494567
Affiliations:
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Douglas</name></author><author><name sortKey="Postnikoff, D" sort="Postnikoff, D" uniqKey="Postnikoff D" first="D" last="Postnikoff">D. Postnikoff</name></author><author><name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S" last="Calne">S. Calne</name></author><author><name sortKey="Woodward, W" sort="Woodward, W" uniqKey="Woodward W" first="W" last="Woodward">W. Woodward</name></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2494567</idno><idno type="pmid">2494567</idno><idno type="wicri:Area/PubMed/Corpus">001C31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C31</idno><idno type="wicri:Area/PubMed/Curation">001C31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C31</idno><idno type="wicri:Area/PubMed/Checkpoint">001C31</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C31</idno><idno type="wicri:Area/Ncbi/Merge">001798</idno><idno type="wicri:Area/Ncbi/Curation">001798</idno><idno type="wicri:Area/Ncbi/Checkpoint">001798</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of dietary protein on the efficacy of L-dopa: a double-blind study.</title><author><name sortKey="Tsui, J K" sort="Tsui, J K" uniqKey="Tsui J" first="J K" last="Tsui">J K Tsui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University Hospital, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University Hospital, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Ross, S" sort="Ross, S" uniqKey="Ross S" first="S" last="Ross">S. Ross</name></author><author><name sortKey="Poulin, K" sort="Poulin, K" uniqKey="Poulin K" first="K" last="Poulin">K. Poulin</name></author><author><name sortKey="Douglas, J" sort="Douglas, J" uniqKey="Douglas J" first="J" last="Douglas">J. Douglas</name></author><author><name sortKey="Postnikoff, D" sort="Postnikoff, D" uniqKey="Postnikoff D" first="D" last="Postnikoff">D. Postnikoff</name></author><author><name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S" last="Calne">S. Calne</name></author><author><name sortKey="Woodward, W" sort="Woodward, W" uniqKey="Woodward W" first="W" last="Woodward">W. Woodward</name></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Bromocriptine (therapeutic use)</term><term>Carbidopa (therapeutic use)</term><term>Clinical Trials as Topic</term><term>Dietary Proteins</term><term>Double-Blind Method</term><term>Drug Combinations (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diet therapy)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Random Allocation</term><term>Selegiline (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Bromocriptine</term><term>Carbidopa</term><term>Drug Combinations</term><term>Levodopa</term><term>Selegiline</term></keywords><keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term><term>Dietary Proteins</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Random Allocation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We randomly placed 10 parkinsonian patients on high- and low-protein diets that tasted and looked alike, each for 1 week. All patients were taking L-dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged. A "blind" physician recorded the modified Columbia scores, objective measurements of rigidity, movement velocity, and pegboard tests three times a day for 5 days during each week. The patients recorded fluctuations hour to hour. We measured serial blood L-dopa levels on day 4 of each week. Performance was significantly better while the patients were on low-protein diets. These results did not correlate with blood L-dopa levels, which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of "off" hours. Thus, high dietary protein probably affects the efficacy of L-dopa at a central level.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name><name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S" last="Calne">S. Calne</name><name sortKey="Douglas, J" sort="Douglas, J" uniqKey="Douglas J" first="J" last="Douglas">J. Douglas</name><name sortKey="Postnikoff, D" sort="Postnikoff, D" uniqKey="Postnikoff D" first="D" last="Postnikoff">D. Postnikoff</name><name sortKey="Poulin, K" sort="Poulin, K" uniqKey="Poulin K" first="K" last="Poulin">K. Poulin</name><name sortKey="Ross, S" sort="Ross, S" uniqKey="Ross S" first="S" last="Ross">S. Ross</name><name sortKey="Woodward, W" sort="Woodward, W" uniqKey="Woodward W" first="W" last="Woodward">W. Woodward</name></noCountry><country name="Canada"><noRegion><name sortKey="Tsui, J K" sort="Tsui, J K" uniqKey="Tsui J" first="J K" last="Tsui">J K Tsui</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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