Neuroimaging of brain changes associated with cognitive impairment in Parkinson’s disease
Identifieur interne : 001420 ( Ncbi/Checkpoint ); précédent : 001419; suivant : 001421Neuroimaging of brain changes associated with cognitive impairment in Parkinson’s disease
Auteurs : Leigh Christopher [Canada] ; Antonio P. Strafella [Canada]Source :
- Journal of neuropsychology [ 1748-6645 ] ; 2013.
English descriptors
- KwdEn :
- Brain (diagnostic imaging), Brain (pathology), Brain (physiopathology), Cognition Disorders (complications), Cognition Disorders (diagnostic imaging), Cognition Disorders (pathology), Cognition Disorders (physiopathology), Humans, Nerve Fibers, Myelinated (pathology), Nerve Fibers, Unmyelinated (pathology), Neural Pathways (pathology), Neural Pathways (physiopathology), Neuroimaging, Parkinson Disease (complications), Parkinson Disease (diagnostic imaging), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Radionuclide Imaging.
- MESH :
- complications : Cognition Disorders, Parkinson Disease.
- diagnostic imaging : Brain, Cognition Disorders, Parkinson Disease.
- pathology : Brain, Cognition Disorders, Nerve Fibers, Myelinated, Nerve Fibers, Unmyelinated, Neural Pathways, Parkinson Disease.
- physiopathology : Brain, Cognition Disorders, Neural Pathways, Parkinson Disease.
- Humans, Neuroimaging, Radionuclide Imaging.
Abstract
Cognitive impairment occurs frequently in Parkinson’s disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.
Url:
DOI: 10.1111/jnp.12015
PubMed: 23551844
PubMed Central: 4452222
Affiliations:
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PMC:4452222Le document en format XML
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Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Journal of neuropsychology</title><idno type="ISSN">1748-6645</idno><idno type="eISSN">1748-6653</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (diagnostic imaging)</term><term>Brain (pathology)</term><term>Brain (physiopathology)</term><term>Cognition Disorders (complications)</term><term>Cognition Disorders (diagnostic imaging)</term><term>Cognition Disorders (pathology)</term><term>Cognition Disorders (physiopathology)</term><term>Humans</term><term>Nerve Fibers, Myelinated (pathology)</term><term>Nerve Fibers, Unmyelinated (pathology)</term><term>Neural Pathways (pathology)</term><term>Neural Pathways (physiopathology)</term><term>Neuroimaging</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Radionuclide Imaging</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Cognition Disorders</term><term>Nerve Fibers, Myelinated</term><term>Nerve Fibers, Unmyelinated</term><term>Neural Pathways</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Cognition Disorders</term><term>Neural Pathways</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Neuroimaging</term><term>Radionuclide Imaging</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cognitive impairment occurs frequently in Parkinson’s disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name></region><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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