Ventricular dilatation and brain atrophy in patients with Parkinson's disease with incipient dementia.
Identifieur interne : 000E49 ( Ncbi/Checkpoint ); précédent : 000E48; suivant : 000E50Ventricular dilatation and brain atrophy in patients with Parkinson's disease with incipient dementia.
Auteurs : Richard Camicioli [Canada] ; Jennifer Sabino ; Myrlene Gee ; Thomas Bouchard ; Nancy Fisher ; Chris Hanstock ; Derek Emery ; W R Wayne MartinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Atrophy (etiology), Atrophy (pathology), Brain (physiopathology), Cerebral Ventricles (physiopathology), Cognition Disorders (diagnosis), Cognition Disorders (etiology), Dementia (complications), Dementia (pathology), Dilatation, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (pathology), Statistics as Topic, Time Factors.
- MESH :
- complications : Dementia, Parkinson Disease.
- diagnosis : Cognition Disorders.
- etiology : Atrophy, Cognition Disorders.
- pathology : Atrophy, Dementia, Parkinson Disease.
- physiopathology : Brain, Cerebral Ventricles.
- Aged, Dilatation, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Neuropsychological Tests, Statistics as Topic, Time Factors.
Abstract
Age-related ventricular enlargement is accelerated in Alzheimer's disease, but its relationship to cognitive decline in Parkinson's disease is less clear, even though dementia is common in Parkinson's disease. Our goals were to determine if greater enlargement of the ventricles and gray or white matter atrophy occurred in Parkinson's disease patients developing cognitive decline. Older nondemented patients with Parkinson's disease (33) and age- and sex-matched controls (39) were recruited and prospectively assessed for the development of significant cognitive decline over 36 months. Magnetic resonance imaging was obtained every 18 months, and ventricular volume and total brain gray and white matter volumes were measured using reliable segmentation of T1-weighted volumetric scans. Subjects with incidental intracranial abnormalities, an atypical course, and stroke as well as dropouts were excluded from a cohort of 52 patients and 50 controls. Among 33 patients and 39 controls, 10 patients and 3 controls developed significant cognitive impairment or dementia. Ventricular change and Parkinson's disease status were significantly associated with dementia. Ventricular change was significantly correlated with change in Mini-Mental Status Examination in the Parkinson's disease with dementia group (r = 0.87, P = .001). Gray matter atrophy was greater in Parkinson's disease with dementia, with similar change over time in both Parkinson's disease and Parkinson's disease with dementia. White matter volumes were not significantly different between Parkinson's disease and Parkinson's disease with dementia; however, the decrease over time might be greater in Parkinson's disease with dementia. Ventricular dilatation occurs early in the course of significant cognitive decline in patients with Parkinson's disease, possibly reflecting both cortical gray and white matter loss.
DOI: 10.1002/mds.23700
PubMed: 21442661
Affiliations:
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sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name></author><author><name sortKey="Fisher, Nancy" sort="Fisher, Nancy" uniqKey="Fisher N" first="Nancy" last="Fisher">Nancy Fisher</name></author><author><name sortKey="Hanstock, Chris" sort="Hanstock, Chris" uniqKey="Hanstock C" first="Chris" last="Hanstock">Chris Hanstock</name></author><author><name sortKey="Emery, Derek" sort="Emery, Derek" uniqKey="Emery D" first="Derek" last="Emery">Derek Emery</name></author><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21442661</idno><idno type="pmid">21442661</idno><idno type="doi">10.1002/mds.23700</idno><idno type="wicri:Area/PubMed/Corpus">000C04</idno><idno type="wicri:explorRef" 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rcamicio@ualberta.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Sabino, Jennifer" sort="Sabino, Jennifer" uniqKey="Sabino J" first="Jennifer" last="Sabino">Jennifer Sabino</name></author><author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name></author><author><name sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name></author><author><name sortKey="Fisher, Nancy" sort="Fisher, Nancy" uniqKey="Fisher N" first="Nancy" last="Fisher">Nancy Fisher</name></author><author><name sortKey="Hanstock, Chris" sort="Hanstock, Chris" uniqKey="Hanstock C" first="Chris" last="Hanstock">Chris Hanstock</name></author><author><name sortKey="Emery, Derek" sort="Emery, Derek" uniqKey="Emery D" first="Derek" last="Emery">Derek Emery</name></author><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Atrophy (etiology)</term><term>Atrophy (pathology)</term><term>Brain (physiopathology)</term><term>Cerebral Ventricles (physiopathology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Dementia (complications)</term><term>Dementia (pathology)</term><term>Dilatation</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Statistics as Topic</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atrophy</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Cerebral Ventricles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Dilatation</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Statistics as Topic</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Age-related ventricular enlargement is accelerated in Alzheimer's disease, but its relationship to cognitive decline in Parkinson's disease is less clear, even though dementia is common in Parkinson's disease. Our goals were to determine if greater enlargement of the ventricles and gray or white matter atrophy occurred in Parkinson's disease patients developing cognitive decline. Older nondemented patients with Parkinson's disease (33) and age- and sex-matched controls (39) were recruited and prospectively assessed for the development of significant cognitive decline over 36 months. Magnetic resonance imaging was obtained every 18 months, and ventricular volume and total brain gray and white matter volumes were measured using reliable segmentation of T1-weighted volumetric scans. Subjects with incidental intracranial abnormalities, an atypical course, and stroke as well as dropouts were excluded from a cohort of 52 patients and 50 controls. Among 33 patients and 39 controls, 10 patients and 3 controls developed significant cognitive impairment or dementia. Ventricular change and Parkinson's disease status were significantly associated with dementia. Ventricular change was significantly correlated with change in Mini-Mental Status Examination in the Parkinson's disease with dementia group (r = 0.87, P = .001). Gray matter atrophy was greater in Parkinson's disease with dementia, with similar change over time in both Parkinson's disease and Parkinson's disease with dementia. White matter volumes were not significantly different between Parkinson's disease and Parkinson's disease with dementia; however, the decrease over time might be greater in Parkinson's disease with dementia. Ventricular dilatation occurs early in the course of significant cognitive decline in patients with Parkinson's disease, possibly reflecting both cortical gray and white matter loss.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name><name sortKey="Emery, Derek" sort="Emery, Derek" uniqKey="Emery D" first="Derek" last="Emery">Derek Emery</name><name sortKey="Fisher, Nancy" sort="Fisher, Nancy" uniqKey="Fisher N" first="Nancy" last="Fisher">Nancy Fisher</name><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name><name sortKey="Hanstock, Chris" sort="Hanstock, Chris" uniqKey="Hanstock C" first="Chris" last="Hanstock">Chris Hanstock</name><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name><name sortKey="Sabino, Jennifer" sort="Sabino, Jennifer" uniqKey="Sabino J" first="Jennifer" last="Sabino">Jennifer Sabino</name></noCountry><country name="Canada"><noRegion><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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