Effect of LY 171555 and CY 208-243 on tremor suppression in the MPTP monkey model of parkinsonism.
Identifieur interne : 000332 ( Ncbi/Checkpoint ); précédent : 000331; suivant : 000333Effect of LY 171555 and CY 208-243 on tremor suppression in the MPTP monkey model of parkinsonism.
Auteurs : B. Gomez-Mancilla [Canada] ; R. Boucher ; P J BédardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1992.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Antiparkinson Agents (therapeutic use), Dopamine Agents (therapeutic use), Dose-Response Relationship, Drug, Drug Therapy, Combination, Electromyography, Ergolines (therapeutic use), Female, Indoles (therapeutic use), Injections, Subcutaneous, Macaca fascicularis, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Phenanthridines (therapeutic use), Quinpirole, Tremor (chemically induced), Tremor (drug therapy).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agents, Ergolines, Indoles, Phenanthridines.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Quinpirole.
- chemically induced : Parkinson Disease, Secondary, Tremor.
- drug therapy : Parkinson Disease, Secondary, Tremor.
- Animals, Dose-Response Relationship, Drug, Drug Therapy, Combination, Electromyography, Female, Injections, Subcutaneous, Macaca fascicularis.
Abstract
The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208-243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest tremor in the limbs. The D2 agonist suppressed rest tremor in a dose-dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.
DOI: 10.1002/mds.870070108
PubMed: 1348351
Affiliations:
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pubmed:1348351Le document en format XML
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Boucher</name></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1348351</idno><idno type="pmid">1348351</idno><idno type="doi">10.1002/mds.870070108</idno><idno type="wicri:Area/PubMed/Corpus">001A99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A99</idno><idno type="wicri:Area/PubMed/Curation">001A99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A99</idno><idno type="wicri:Area/PubMed/Checkpoint">001A99</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A99</idno><idno type="wicri:Area/Ncbi/Merge">000332</idno><idno type="wicri:Area/Ncbi/Curation">000332</idno><idno type="wicri:Area/Ncbi/Checkpoint">000332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of LY 171555 and CY 208-243 on tremor suppression in the MPTP monkey model of parkinsonism.</title><author><name sortKey="Gomez Mancilla, B" sort="Gomez Mancilla, B" uniqKey="Gomez Mancilla B" first="B" last="Gomez-Mancilla">B. Gomez-Mancilla</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Boucher, R" sort="Boucher, R" uniqKey="Boucher R" first="R" last="Boucher">R. Boucher</name></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Antiparkinson Agents (therapeutic use)</term><term>Dopamine Agents (therapeutic use)</term><term>Dose-Response Relationship, Drug</term><term>Drug Therapy, Combination</term><term>Electromyography</term><term>Ergolines (therapeutic use)</term><term>Female</term><term>Indoles (therapeutic use)</term><term>Injections, Subcutaneous</term><term>Macaca fascicularis</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Phenanthridines (therapeutic use)</term><term>Quinpirole</term><term>Tremor (chemically induced)</term><term>Tremor (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agents</term><term>Ergolines</term><term>Indoles</term><term>Phenanthridines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Quinpirole</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Drug Therapy, Combination</term><term>Electromyography</term><term>Female</term><term>Injections, Subcutaneous</term><term>Macaca fascicularis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208-243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest tremor in the limbs. The D2 agonist suppressed rest tremor in a dose-dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name><name sortKey="Boucher, R" sort="Boucher, R" uniqKey="Boucher R" first="R" last="Boucher">R. Boucher</name></noCountry><country name="Canada"><noRegion><name sortKey="Gomez Mancilla, B" sort="Gomez Mancilla, B" uniqKey="Gomez Mancilla B" first="B" last="Gomez-Mancilla">B. Gomez-Mancilla</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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