Neuronal recordings in Parkinson's disease patients with dyskinesias induced by apomorphine.
Identifieur interne : 000091 ( Ncbi/Checkpoint ); précédent : 000090; suivant : 000092Neuronal recordings in Parkinson's disease patients with dyskinesias induced by apomorphine.
Auteurs : A M Lozano [Canada] ; A E Lang ; R. Levy ; W. Hutchison ; J. DostrovskySource :
- Annals of neurology [ 0364-5134 ] ; 2000.
English descriptors
- KwdEn :
- Action Potentials (drug effects), Affect (drug effects), Apomorphine (adverse effects), Dopamine Agonists (adverse effects), Dyskinesia, Drug-Induced (physiopathology), Electrophysiology, Globus Pallidus (cytology), Globus Pallidus (physiopathology), Globus Pallidus (surgery), Humans, Neurons (physiology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Subthalamic Nucleus (cytology), Subthalamic Nucleus (physiopathology).
- MESH :
- chemical , adverse effects : Apomorphine, Dopamine Agonists.
- cytology : Globus Pallidus, Subthalamic Nucleus.
- drug effects : Action Potentials, Affect.
- drug therapy : Parkinson Disease.
- physiology : Neurons.
- physiopathology : Dyskinesia, Drug-Induced, Globus Pallidus, Parkinson Disease, Subthalamic Nucleus.
- surgery : Globus Pallidus, Parkinson Disease.
- Electrophysiology, Humans.
Abstract
Dopaminergic agents reverse parkinsonism but commonly induce dyskinesia in patients with Parkinson's disease (PD) on long-term levodopa therapy. The aim of this study was to determine the neurophysiologic correlates of the amelioration of parkinsonism and the involuntary movements produced by the dopamine agonist apomorphine. Seventeen PD patients were given apomorphine (2-6 mg) before surgery. Neural activity was recorded for individual neurons and for populations of neurons before and after apomorphine. Both internal (GPi) and external (GPe) segments of the globus pallidus were sampled in patients undergoing pallidal surgery. The subthalamic nucleus (STN) was sampled in STN surgery patients. Results suggest that dopaminergic agents act by decreasing GPi and STN activity, and increasing GPe activity, and that drug-induced dyskinesias results from a large reduction in GPi firing.
PubMed: 10762141
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001647
- to stream PubMed, to step Curation: 001647
- to stream PubMed, to step Checkpoint: 001647
- to stream Ncbi, to step Merge: 000091
- to stream Ncbi, to step Curation: 000091
Links to Exploration step
pubmed:10762141Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuronal recordings in Parkinson's disease patients with dyskinesias induced by apomorphine.</title><author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, University of Toronto, The Toronto Hospital, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Toronto, The Toronto Hospital, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Levy, R" sort="Levy, R" uniqKey="Levy R" first="R" last="Levy">R. Levy</name></author><author><name sortKey="Hutchison, W" sort="Hutchison, W" uniqKey="Hutchison W" first="W" last="Hutchison">W. Hutchison</name></author><author><name sortKey="Dostrovsky, J" sort="Dostrovsky, J" uniqKey="Dostrovsky J" first="J" last="Dostrovsky">J. Dostrovsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10762141</idno><idno type="pmid">10762141</idno><idno type="wicri:Area/PubMed/Corpus">001647</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001647</idno><idno type="wicri:Area/PubMed/Curation">001647</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001647</idno><idno type="wicri:Area/PubMed/Checkpoint">001647</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001647</idno><idno type="wicri:Area/Ncbi/Merge">000091</idno><idno type="wicri:Area/Ncbi/Curation">000091</idno><idno type="wicri:Area/Ncbi/Checkpoint">000091</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuronal recordings in Parkinson's disease patients with dyskinesias induced by apomorphine.</title><author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, University of Toronto, The Toronto Hospital, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Toronto, The Toronto Hospital, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Levy, R" sort="Levy, R" uniqKey="Levy R" first="R" last="Levy">R. Levy</name></author><author><name sortKey="Hutchison, W" sort="Hutchison, W" uniqKey="Hutchison W" first="W" last="Hutchison">W. Hutchison</name></author><author><name sortKey="Dostrovsky, J" sort="Dostrovsky, J" uniqKey="Dostrovsky J" first="J" last="Dostrovsky">J. Dostrovsky</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (drug effects)</term><term>Affect (drug effects)</term><term>Apomorphine (adverse effects)</term><term>Dopamine Agonists (adverse effects)</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Electrophysiology</term><term>Globus Pallidus (cytology)</term><term>Globus Pallidus (physiopathology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Neurons (physiology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Subthalamic Nucleus (cytology)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Apomorphine</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Globus Pallidus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Action Potentials</term><term>Affect</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electrophysiology</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopaminergic agents reverse parkinsonism but commonly induce dyskinesia in patients with Parkinson's disease (PD) on long-term levodopa therapy. The aim of this study was to determine the neurophysiologic correlates of the amelioration of parkinsonism and the involuntary movements produced by the dopamine agonist apomorphine. Seventeen PD patients were given apomorphine (2-6 mg) before surgery. Neural activity was recorded for individual neurons and for populations of neurons before and after apomorphine. Both internal (GPi) and external (GPe) segments of the globus pallidus were sampled in patients undergoing pallidal surgery. The subthalamic nucleus (STN) was sampled in STN surgery patients. Results suggest that dopaminergic agents act by decreasing GPi and STN activity, and increasing GPe activity, and that drug-induced dyskinesias results from a large reduction in GPi firing.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Dostrovsky, J" sort="Dostrovsky, J" uniqKey="Dostrovsky J" first="J" last="Dostrovsky">J. Dostrovsky</name><name sortKey="Hutchison, W" sort="Hutchison, W" uniqKey="Hutchison W" first="W" last="Hutchison">W. Hutchison</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name><name sortKey="Levy, R" sort="Levy, R" uniqKey="Levy R" first="R" last="Levy">R. Levy</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000091 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000091 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:10762141
|texte= Neuronal recordings in Parkinson's disease patients with dyskinesias induced by apomorphine.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:10762141" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |