Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Identifieur interne : 006072 ( Main/Merge ); précédent : 006071; suivant : 006073Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Auteurs : C. Schwab [Canada] ; A J Demaggio ; N. Ghoshal ; L I Binder ; J. Kuret ; P L McgeerSource :
- Neurobiology of aging [ 0197-4580 ]
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Amyotrophic Lateral Sclerosis (metabolism), Amyotrophic Lateral Sclerosis (pathology), Antibody Specificity, Brain (enzymology), Brain (pathology), Casein Kinases, Female, Humans, Immunohistochemistry, Inclusion Bodies (chemistry), Inclusion Bodies (enzymology), Lewy Bodies (chemistry), Lewy Bodies (enzymology), Male, Middle Aged, Neurodegenerative Diseases (metabolism), Neurodegenerative Diseases (pathology), Neurofibrillary Tangles (chemistry), Neurofibrillary Tangles (enzymology), Neuroglia (chemistry), Neuroglia (enzymology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Protein Kinases (analysis), Protein Kinases (immunology), Protein Kinases (metabolism), tau Proteins (analysis), tau Proteins (immunology), tau Proteins (metabolism).
- MESH :
- chemical , analysis : Protein Kinases, tau Proteins.
- chemical , immunology : Protein Kinases, tau Proteins.
- chemical , metabolism : Protein Kinases, tau Proteins.
- chemical : Casein Kinases.
- chemistry : Inclusion Bodies, Lewy Bodies, Neurofibrillary Tangles, Neuroglia.
- enzymology : Brain, Inclusion Bodies, Lewy Bodies, Neurofibrillary Tangles, Neuroglia.
- metabolism : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, Parkinson Disease.
- pathology : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Neurodegenerative Diseases, Parkinson Disease.
- Aged, Aged, 80 and over, Antibody Specificity, Female, Humans, Immunohistochemistry, Male, Middle Aged.
Abstract
The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Cki delta was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and "skein"-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Cki delta and its apparent substrate tau suggests a function for Cki delta in the abnormal processing of tau.
PubMed: 10924763
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pubmed:10924763Le document en format XML
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<term>Alzheimer Disease (metabolism)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Amyotrophic Lateral Sclerosis (metabolism)</term>
<term>Amyotrophic Lateral Sclerosis (pathology)</term>
<term>Antibody Specificity</term>
<term>Brain (enzymology)</term>
<term>Brain (pathology)</term>
<term>Casein Kinases</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Inclusion Bodies (chemistry)</term>
<term>Inclusion Bodies (enzymology)</term>
<term>Lewy Bodies (chemistry)</term>
<term>Lewy Bodies (enzymology)</term>
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<term>Neuroglia (enzymology)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Protein Kinases (analysis)</term>
<term>Protein Kinases (immunology)</term>
<term>Protein Kinases (metabolism)</term>
<term>tau Proteins (analysis)</term>
<term>tau Proteins (immunology)</term>
<term>tau Proteins (metabolism)</term>
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<term>tau Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protein Kinases</term>
<term>tau Proteins</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Inclusion Bodies</term>
<term>Lewy Bodies</term>
<term>Neurofibrillary Tangles</term>
<term>Neuroglia</term>
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<term>Lewy Bodies</term>
<term>Neurofibrillary Tangles</term>
<term>Neuroglia</term>
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<term>Amyotrophic Lateral Sclerosis</term>
<term>Neurodegenerative Diseases</term>
<term>Parkinson Disease</term>
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<term>Neurodegenerative Diseases</term>
<term>Parkinson Disease</term>
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<term>Aged, 80 and over</term>
<term>Antibody Specificity</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
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<front><div type="abstract" xml:lang="en">The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls. Cki delta was found to be associated generally with granulovacuolar bodies and tau-containing neurofibrillary tangles in AD, DS, PSP, PDC, PPND, and controls, and Pick bodies and ballooned neurons in PiD. It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. It was also not associated with tau-negative Lewy bodies in PD and DLB, Hirano bodies in PDC, Marinesco bodies in PD, AD, and controls and "skein"-like inclusions in anterior motor neurons in ALS. The colocalization of the kinase Cki delta and its apparent substrate tau suggests a function for Cki delta in the abnormal processing of tau.</div>
</front>
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