ParkinsonCanadaV1, Main, Merge, bibRecord, 005673

Familial Parkinson's disease: possible role of environmental factors.

Identifieur interne : 005673 ( Main/Merge ); précédent : 005672; suivant : 005674

Familial Parkinson's disease: possible role of environmental factors.

Auteurs : S. Calne [Canada] ; B. Schoenberg ; W. Martin ; R J Uitti ; P. Spencer ; D B Calne

Source :

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [ 0317-1671 ] ; 1987.

RBID : pubmed:3664372

English descriptors

KwdEn :
- Adult, Age Factors, Diseases in Twins, Environmental Exposure, Female, Humans, Male, Middle Aged, Parkinson Disease (etiology), Parkinson Disease (genetics), Time Factors.
MESH :
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Adult, Age Factors, Diseases in Twins, Environmental Exposure, Female, Humans, Male, Middle Aged, Time Factors.

Abstract

We report here six families with Parkinson's disease in whom the onset of symptoms tended to occur at approximately the same time irrespective of the age of the patient. The mean difference in the time of onset in different generations was 4.6 years while the mean difference in age of onset in children and parents was 25.2 years. We construe this pattern of age separation within families as suggestive of an environmental rather than genetic cause. Support for this view derives from the lack of correlation between occurrence of the disease and the degree of consanguinity. We conclude that our findings are in accord with the hypothesis which attributes the cause of some cases of Parkinson's disease to early, subclinical environmental damage followed by age-related attrition of neurons within the central nervous system.

PubMed: 3664372

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pubmed:3664372

Le document en format XML

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<author><name sortKey="Martin, W" sort="Martin, W" uniqKey="Martin W" first="W" last="Martin">W. Martin</name>
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<author><name sortKey="Uitti, R J" sort="Uitti, R J" uniqKey="Uitti R" first="R J" last="Uitti">R J Uitti</name>
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<author><name sortKey="Spencer, P" sort="Spencer, P" uniqKey="Spencer P" first="P" last="Spencer">P. Spencer</name>
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<author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name>
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<term>Middle Aged</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Time Factors</term>
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<term>Diseases in Twins</term>
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<front><div type="abstract" xml:lang="en">We report here six families with Parkinson's disease in whom the onset of symptoms tended to occur at approximately the same time irrespective of the age of the patient. The mean difference in the time of onset in different generations was 4.6 years while the mean difference in age of onset in children and parents was 25.2 years. We construe this pattern of age separation within families as suggestive of an environmental rather than genetic cause. Support for this view derives from the lack of correlation between occurrence of the disease and the degree of consanguinity. We conclude that our findings are in accord with the hypothesis which attributes the cause of some cases of Parkinson's disease to early, subclinical environmental damage followed by age-related attrition of neurons within the central nervous system.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Familial Parkinson's disease: possible role of environmental factors.

Familial Parkinson's disease: possible role of environmental factors.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki