Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat
Identifieur interne : 004F98 ( Main/Merge ); précédent : 004F97; suivant : 004F99Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat
Auteurs : François B. Jolicoeur [Canada] ; Robert Rivest [Canada] ; Andrea Drumheller [Canada]Source :
- Brain Research Bulletin [ 0361-9230 ] ; 1991.
Abstract
Bilateral administration of 6-hydroxydopamine in the medial forebrain bundle at the level of the posterolateral hypothalamus in rats resulted in hypokinesia, muscular rigidity and tremor as determined by various behavioral assessment procedures. These neurological signs were accompanied by marked decreases in the concentrations of dopamine and its main metabolites dihydroxyphenylacetic acid and homovanillic acid in both striatum and nucleus accumbens. Administration of apomorphine (1 mg/kg) or L-Dopa (60 mg/kg) reversed or totally abolished the hypokinesia, rigidity and tremor in lesioned animals. Together, the present findings demonstrate that bilateral intrahypothalamic administration of 6-OHDA results in the appearance of the three cardinal symptoms of Parkinson's disease in rats. This model should prove to be valuable for both the study of the neuropathological processes underlying the neurological signs of this disease and the screening of potential antiparkinson agents.
Url:
DOI: 10.1016/0361-9230(91)90245-F
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000D26
- to stream Istex, to step Curation: 000D26
- to stream Istex, to step Checkpoint: 001F03
Links to Exploration step
ISTEX:B376BB35668D566C4A0DA568FB020F444430A8B0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat</title>
<author><name sortKey="Jolicoeur, Francois B" sort="Jolicoeur, Francois B" uniqKey="Jolicoeur F" first="François B." last="Jolicoeur">François B. Jolicoeur</name>
</author>
<author><name sortKey="Rivest, Robert" sort="Rivest, Robert" uniqKey="Rivest R" first="Robert" last="Rivest">Robert Rivest</name>
</author>
<author><name sortKey="Drumheller, Andrea" sort="Drumheller, Andrea" uniqKey="Drumheller A" first="Andrea" last="Drumheller">Andrea Drumheller</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B376BB35668D566C4A0DA568FB020F444430A8B0</idno>
<date when="1991" year="1991">1991</date>
<idno type="doi">10.1016/0361-9230(91)90245-F</idno>
<idno type="url">https://api-v5.istex.fr/document/B376BB35668D566C4A0DA568FB020F444430A8B0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000D26</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D26</idno>
<idno type="wicri:Area/Istex/Curation">000D26</idno>
<idno type="wicri:Area/Istex/Checkpoint">001F03</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001F03</idno>
<idno type="wicri:doubleKey">0361-9230:1991:Jolicoeur F:hypokinesia:rigidity:and</idno>
<idno type="wicri:Area/Main/Merge">004F98</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat</title>
<author><name sortKey="Jolicoeur, Francois B" sort="Jolicoeur, Francois B" uniqKey="Jolicoeur F" first="François B." last="Jolicoeur">François B. Jolicoeur</name>
<affiliation wicri:level="1"><country>Canada</country>
<wicri:regionArea>Department of Psychiatry, Faculty of Medicine, University of Sherbrooke, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivest, Robert" sort="Rivest, Robert" uniqKey="Rivest R" first="Robert" last="Rivest">Robert Rivest</name>
<affiliation wicri:level="1"><country>Canada</country>
<wicri:regionArea>Department of Psychiatry, Faculty of Medicine, University of Sherbrooke, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drumheller, Andrea" sort="Drumheller, Andrea" uniqKey="Drumheller A" first="Andrea" last="Drumheller">Andrea Drumheller</name>
<affiliation wicri:level="1"><country>Canada</country>
<wicri:regionArea>Department of Psychiatry, Faculty of Medicine, University of Sherbrooke, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain Research Bulletin</title>
<title level="j" type="abbrev">BRB</title>
<idno type="ISSN">0361-9230</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1991">1991</date>
<biblScope unit="volume">26</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="317">317</biblScope>
<biblScope unit="page" to="320">320</biblScope>
</imprint>
<idno type="ISSN">0361-9230</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0361-9230</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Bilateral administration of 6-hydroxydopamine in the medial forebrain bundle at the level of the posterolateral hypothalamus in rats resulted in hypokinesia, muscular rigidity and tremor as determined by various behavioral assessment procedures. These neurological signs were accompanied by marked decreases in the concentrations of dopamine and its main metabolites dihydroxyphenylacetic acid and homovanillic acid in both striatum and nucleus accumbens. Administration of apomorphine (1 mg/kg) or L-Dopa (60 mg/kg) reversed or totally abolished the hypokinesia, rigidity and tremor in lesioned animals. Together, the present findings demonstrate that bilateral intrahypothalamic administration of 6-OHDA results in the appearance of the three cardinal symptoms of Parkinson's disease in rats. This model should prove to be valuable for both the study of the neuropathological processes underlying the neurological signs of this disease and the screening of potential antiparkinson agents.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004F98 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004F98 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:B376BB35668D566C4A0DA568FB020F444430A8B0 |texte= Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat }}
This area was generated with Dilib version V0.6.29. |