Brain proteasomal function in sporadic Parkinson's disease and related disorders
Identifieur interne : 003548 ( Main/Merge ); précédent : 003547; suivant : 003549Brain proteasomal function in sporadic Parkinson's disease and related disorders
Auteurs : Yoshiaki Furukawa [Canada] ; Sophie Vigouroux [France] ; Henry Wong [Canada] ; Mark Guttman [Canada] ; Ali H. Rajput [Canada] ; LEE ANG [Canada] ; Marièle Briand [France] ; Stephen J. Kish [Canada] ; Yves Briand [France]Source :
- Annals of neurology [ 0364-5134 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000B63
- to stream PascalFrancis, to step Curation: 000160
- to stream PascalFrancis, to step Checkpoint: 000A39
Links to Exploration step
Pascal:02-0447146Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Brain proteasomal function in sporadic Parkinson's disease and related disorders</title>
<author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Neurology, University of Saskatchewan</s1>
<s2>Saskatoon, Saskatchewan</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee Ang" sort="Lee Ang" uniqKey="Lee Ang" last="Lee Ang">LEE ANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology, University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>London, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0447146</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0447146 INIST</idno>
<idno type="RBID">Pascal:02-0447146</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000B63</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000160</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000A39</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000A39</idno>
<idno type="wicri:doubleKey">0364-5134:2002:Furukawa Y:brain:proteasomal:function</idno>
<idno type="wicri:Area/Main/Merge">003548</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Brain proteasomal function in sporadic Parkinson's disease and related disorders</title>
<author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Neurology, University of Saskatchewan</s1>
<s2>Saskatoon, Saskatchewan</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee Ang" sort="Lee Ang" uniqKey="Lee Ang" last="Lee Ang">LEE ANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology, University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>London, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
<author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health-Clarke Division</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Laboratoire de Biochimie Appliquée, Université Blaise Pascal</s1>
<s2>Clermont Ferrand</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
<orgName type="university">Université Blaise-Pascal</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autopsy</term>
<term>Brain (vertebrata)</term>
<term>Exploration</term>
<term>Human</term>
<term>Multicatalytic endopeptidase complex</term>
<term>Parkinson disease</term>
<term>Pathology</term>
<term>Sporadic</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Sporadique</term>
<term>Multicatalytic endopeptidase complex</term>
<term>Encéphale</term>
<term>Anatomopathologie</term>
<term>Exploration</term>
<term>Autopsie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>France</li>
</country>
<region><li>Auvergne (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
</region>
<settlement><li>Clermont-Ferrand</li>
</settlement>
<orgName><li>Université Blaise-Pascal</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name>
</noRegion>
<name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name>
<name sortKey="Lee Ang" sort="Lee Ang" uniqKey="Lee Ang" last="Lee Ang">LEE ANG</name>
<name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name>
</region>
<name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name>
<name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003548 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003548 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Merge |type= RBID |clé= Pascal:02-0447146 |texte= Brain proteasomal function in sporadic Parkinson's disease and related disorders }}
This area was generated with Dilib version V0.6.29. |