Dihydrotetrabenazine Positron Emission Tomography Imaging in Early, Untreated Parkinson's Disease
Identifieur interne : 002617 ( Main/Merge ); précédent : 002616; suivant : 002618Dihydrotetrabenazine Positron Emission Tomography Imaging in Early, Untreated Parkinson's Disease
Auteurs : W. R. Wayne Martin [Canada] ; Marguerite Wieler [Canada] ; A. Jon Stoessl [Canada] ; Michael Schulzer [Canada]Source :
- Annals of neurology [ 0364-5134 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: To determine the sensitivity of positron emission tomography with 11C-labeled dihydrotetrabenazine (DTBZ) to the nigrostriatal changes associated with early, untreated Parkinson's disease (PD), and to determine the correlation between any regionally reduced DTBZ binding and the major motor features of PD. Methods: Untreated patients with early PD (n = 27) and age-matched control subjects (n = 33) underwent DTBZ/positron emission tomography scanning to measure binding to the presynaptic type 2 vesicular monoamine transporter site in dopaminergic neurons in basal ganglia regions. Clinical symptoms were rated with the Unified Parkinson's Disease Rating Scale. Results: Mean striatal DTBZ binding values in the patient group were decreased as compared with control subjects (p < 0.001) in all regions examined. The difference between patients and control subjects was most marked in the midputamen, where only one patient had DTBZ binding within 3 standard deviations of the control mean. Bradykinesia and rigidity scores correlated with DTBZ binding in the contralateral midputamen region, particularly for the clinically least affected limbs. Tremor scores showed no significant correlation. Interpretation: Reduced striatal binding of DTBZ is associated with early PD. Tremor appears to be only partially related to presynaptic dopaminergic function and may have a mechanism differing from that of symptoms such as bradykinesia. The method appears to be most sensitive in mildly affected individuals with a possible "floor" effect that may limit the degree of additional change occurring once more severe clinical symptoms are evident.
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Wayne Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0192213</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0192213 INIST</idno><idno type="RBID">Pascal:08-0192213</idno><idno type="wicri:Area/PascalFrancis/Corpus">000660</idno><idno type="wicri:Area/PascalFrancis/Curation">000650</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000556</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000556</idno><idno type="wicri:doubleKey">0364-5134:2008:Martin W:dihydrotetrabenazine:positron:emission</idno><idno type="wicri:Area/Main/Merge">002617</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Dihydrotetrabenazine Positron Emission Tomography Imaging in Early, Untreated Parkinson's Disease</title><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To determine the sensitivity of positron emission tomography with <sup>11</sup>C-labeled dihydrotetrabenazine (DTBZ) to the nigrostriatal changes associated with early, untreated Parkinson's disease (PD), and to determine the correlation between any regionally reduced DTBZ binding and the major motor features of PD. Methods: Untreated patients with early PD (n = 27) and age-matched control subjects (n = 33) underwent DTBZ/positron emission tomography scanning to measure binding to the presynaptic type 2 vesicular monoamine transporter site in dopaminergic neurons in basal ganglia regions. Clinical symptoms were rated with the Unified Parkinson's Disease Rating Scale. Results: Mean striatal DTBZ binding values in the patient group were decreased as compared with control subjects (p < 0.001) in all regions examined. The difference between patients and control subjects was most marked in the midputamen, where only one patient had DTBZ binding within 3 standard deviations of the control mean. Bradykinesia and rigidity scores correlated with DTBZ binding in the contralateral midputamen region, particularly for the clinically least affected limbs. Tremor scores showed no significant correlation. Interpretation: Reduced striatal binding of DTBZ is associated with early PD. Tremor appears to be only partially related to presynaptic dopaminergic function and may have a mechanism differing from that of symptoms such as bradykinesia. The method appears to be most sensitive in mildly affected individuals with a possible "floor" effect that may limit the degree of additional change occurring once more severe clinical symptoms are evident.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W. R. Wayne" last="Martin">W. R. Wayne Martin</name></noRegion><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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