Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study
Identifieur interne : 002042 ( Main/Merge ); précédent : 002041; suivant : 002043Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study
Auteurs : R. Nandhagopal [Canada] ; L. Kuramoto [Canada] ; M. Schulzer [Canada] ; E. Mak [Canada] ; J. Cragg [Canada] ; Chong S. Lee [Canada] ; J. Mckenzie [États-Unis] ; S. Mccormick [Canada] ; A. Samii [États-Unis] ; A. Troiano [Canada] ; T. J. Ruth [Canada] ; V. Sossi [Canada] ; R. De La Fuente-Fernandez [Canada] ; Donald B. Calne [Canada] ; A. J. Stoessl [Canada]Source :
- [ 0006-8950 ]
English descriptors
- KwdEn :
- Adult, Aged, Caudate Nucleus (diagnostic imaging), Caudate Nucleus (metabolism), Caudate Nucleus (pathology), Disease Progression, Female, Humans, Male, Middle Aged, Parkinson Disease (diagnostic imaging), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Patient Dropouts, Positron-Emission Tomography, Putamen (diagnostic imaging), Putamen (metabolism), Putamen (pathology), Radiopharmaceuticals (metabolism), Young Adult.
- MESH :
- chemical , metabolism : Radiopharmaceuticals.
- diagnostic imaging : Caudate Nucleus, Parkinson Disease, Putamen.
- metabolism : Caudate Nucleus, Putamen.
- pathology : Caudate Nucleus, Parkinson Disease, Putamen.
- physiopathology : Parkinson Disease.
- Adult, Aged, Disease Progression, Female, Humans, Male, Middle Aged, Patient Dropouts, Positron-Emission Tomography, Young Adult.
Abstract
Parkinson's disease is a heterogeneous disorder with multiple factors contributing to disease initiation and progression. Using serial, multi-tracer positron emission tomography imaging, we studied a cohort of 78 subjects with sporadic Parkinson's disease to understand the disease course better. Subjects were scanned with radiotracers of presynaptic dopaminergic integrity at baseline and again after 4 and 8 years of follow-up. Non-linear multivariate regression analyses, using random effects, of the form BPND(t) or Kocc(t) ae(btdA) c, where BPND tracer binding potential (nondispaceable), KOCC tracer uptake constant a, b, c and d are regression parameters, t is the symptom duration and A is the age at onset, were utilized to model the longitudinal progression of radiotracer binding/uptake. We found that the initial tracer binding/uptake was significantly different in anterior versus posterior striatal subregions, indicating that the degree of denervation at disease onset was different between regions. However, the relative rate of decline in tracer binding/uptake was similar between the striatal subregions. While an antero-posterior gradient of severity was maintained for dopamine synthesis, storage and reuptake, the asymmetry between the more and less affected striatum became less prominent over the disease course. Our study suggests that the mechanisms underlying Parkinson's disease initiation and progression are probably different. Whereas factors responsible for disease initiation affect striatal subregions differently, those factors contributing to disease progression affect all striatal subregions to a similar degree and may therefore reflect non-specific mechanisms such as oxidative stress, inflammation or excitotoxicity.
Url:
DOI: 10.1093/brain/awp209
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000411
- to stream Istex, to step Curation: 000411
- to stream Istex, to step Checkpoint: 000663
- to stream PubMed, to step Corpus: 000E22
- to stream PubMed, to step Curation: 000E22
- to stream PubMed, to step Checkpoint: 000E22
- to stream Ncbi, to step Merge: 000B32
- to stream Ncbi, to step Curation: 000B32
- to stream Ncbi, to step Checkpoint: 000B32
Links to Exploration step
ISTEX:54BBA92A9A3E58370CF3C12ED2373CE9525D23EBLe document en format XML
<record><TEI wicri:istexFullTextTei="no"><teiHeader><fileDesc><titleStmt><title>Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study</title>
<author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R." last="Nandhagopal">R. Nandhagopal</name>
</author>
<author><name sortKey="Kuramoto, L" sort="Kuramoto, L" uniqKey="Kuramoto L" first="L." last="Kuramoto">L. Kuramoto</name>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
</author>
<author><name sortKey="Cragg, J" sort="Cragg, J" uniqKey="Cragg J" first="J." last="Cragg">J. Cragg</name>
</author>
<author><name sortKey="Lee, Chong S" sort="Lee, Chong S" uniqKey="Lee C" first="Chong S." last="Lee">Chong S. Lee</name>
</author>
<author><name sortKey="Mckenzie, J" sort="Mckenzie, J" uniqKey="Mckenzie J" first="J." last="Mckenzie">J. Mckenzie</name>
</author>
<author><name sortKey="Mccormick, S" sort="Mccormick, S" uniqKey="Mccormick S" first="S." last="Mccormick">S. Mccormick</name>
</author>
<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A." last="Samii">A. Samii</name>
</author>
<author><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name>
</author>
<author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name>
</author>
<author><name sortKey="Sossi, V" sort="Sossi, V" uniqKey="Sossi V" first="V." last="Sossi">V. Sossi</name>
</author>
<author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R." last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name>
</author>
<author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name>
</author>
<author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:54BBA92A9A3E58370CF3C12ED2373CE9525D23EB</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1093/brain/awp209</idno>
<idno type="url">https://api-v5.istex.fr/document/54BBA92A9A3E58370CF3C12ED2373CE9525D23EB/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000411</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000411</idno>
<idno type="wicri:Area/Istex/Curation">000411</idno>
<idno type="wicri:Area/Istex/Checkpoint">000663</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000663</idno>
<idno type="wicri:doubleKey">0006-8950:2009:Nandhagopal R:longitudinal:progression:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19690093</idno>
<idno type="wicri:Area/PubMed/Corpus">000E22</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E22</idno>
<idno type="wicri:Area/PubMed/Curation">000E22</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E22</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000E22</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E22</idno>
<idno type="wicri:Area/Ncbi/Merge">000B32</idno>
<idno type="wicri:Area/Ncbi/Curation">000B32</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B32</idno>
<idno type="wicri:Area/Main/Merge">002042</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R." last="Nandhagopal">R. Nandhagopal</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuramoto, L" sort="Kuramoto, L" uniqKey="Kuramoto L" first="L." last="Kuramoto">L. Kuramoto</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cragg, J" sort="Cragg, J" uniqKey="Cragg J" first="J." last="Cragg">J. Cragg</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Chong S" sort="Lee, Chong S" uniqKey="Lee C" first="Chong S." last="Lee">Chong S. Lee</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mckenzie, J" sort="Mckenzie, J" uniqKey="Mckenzie J" first="J." last="Mckenzie">J. Mckenzie</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, University of Washington, Seattle</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName><settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccormick, S" sort="Mccormick, S" uniqKey="Mccormick S" first="S." last="Mccormick">S. Mccormick</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A." last="Samii">A. Samii</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, University of Washington, Seattle</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName><settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>3 TRIUMF, Wesbrook Mall, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sossi, V" sort="Sossi, V" uniqKey="Sossi V" first="V." last="Sossi">V. Sossi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>4 Department of Physics & Astronomy, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R." last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
</author>
</analytic>
<series><idno type="ISSN">0006-8950</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Caudate Nucleus (diagnostic imaging)</term>
<term>Caudate Nucleus (metabolism)</term>
<term>Caudate Nucleus (pathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Patient Dropouts</term>
<term>Positron-Emission Tomography</term>
<term>Putamen (diagnostic imaging)</term>
<term>Putamen (metabolism)</term>
<term>Putamen (pathology)</term>
<term>Radiopharmaceuticals (metabolism)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Caudate Nucleus</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Caudate Nucleus</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Caudate Nucleus</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Patient Dropouts</term>
<term>Positron-Emission Tomography</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Parkinson's disease is a heterogeneous disorder with multiple factors contributing to disease initiation and progression. Using serial, multi-tracer positron emission tomography imaging, we studied a cohort of 78 subjects with sporadic Parkinson's disease to understand the disease course better. Subjects were scanned with radiotracers of presynaptic dopaminergic integrity at baseline and again after 4 and 8 years of follow-up. Non-linear multivariate regression analyses, using random effects, of the form BPND(t) or Kocc(t) ae(btdA) c, where BPND tracer binding potential (nondispaceable), KOCC tracer uptake constant a, b, c and d are regression parameters, t is the symptom duration and A is the age at onset, were utilized to model the longitudinal progression of radiotracer binding/uptake. We found that the initial tracer binding/uptake was significantly different in anterior versus posterior striatal subregions, indicating that the degree of denervation at disease onset was different between regions. However, the relative rate of decline in tracer binding/uptake was similar between the striatal subregions. While an antero-posterior gradient of severity was maintained for dopamine synthesis, storage and reuptake, the asymmetry between the more and less affected striatum became less prominent over the disease course. Our study suggests that the mechanisms underlying Parkinson's disease initiation and progression are probably different. Whereas factors responsible for disease initiation affect striatal subregions differently, those factors contributing to disease progression affect all striatal subregions to a similar degree and may therefore reflect non-specific mechanisms such as oxidative stress, inflammation or excitotoxicity.</div>
</front>
</TEI>
<double doi="10.1093/brain/awp209"><ISTEX><TEI wicri:istexFullTextTei="no"><teiHeader><fileDesc><titleStmt><title>Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study</title>
<author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R." last="Nandhagopal">R. Nandhagopal</name>
</author>
<author><name sortKey="Kuramoto, L" sort="Kuramoto, L" uniqKey="Kuramoto L" first="L." last="Kuramoto">L. Kuramoto</name>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
</author>
<author><name sortKey="Cragg, J" sort="Cragg, J" uniqKey="Cragg J" first="J." last="Cragg">J. Cragg</name>
</author>
<author><name sortKey="Lee, Chong S" sort="Lee, Chong S" uniqKey="Lee C" first="Chong S." last="Lee">Chong S. Lee</name>
</author>
<author><name sortKey="Mckenzie, J" sort="Mckenzie, J" uniqKey="Mckenzie J" first="J." last="Mckenzie">J. Mckenzie</name>
</author>
<author><name sortKey="Mccormick, S" sort="Mccormick, S" uniqKey="Mccormick S" first="S." last="Mccormick">S. Mccormick</name>
</author>
<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A." last="Samii">A. Samii</name>
</author>
<author><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name>
</author>
<author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name>
</author>
<author><name sortKey="Sossi, V" sort="Sossi, V" uniqKey="Sossi V" first="V." last="Sossi">V. Sossi</name>
</author>
<author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R." last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name>
</author>
<author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name>
</author>
<author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:54BBA92A9A3E58370CF3C12ED2373CE9525D23EB</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1093/brain/awp209</idno>
<idno type="url">https://api-v5.istex.fr/document/54BBA92A9A3E58370CF3C12ED2373CE9525D23EB/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000411</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000411</idno>
<idno type="wicri:Area/Istex/Curation">000411</idno>
<idno type="wicri:Area/Istex/Checkpoint">000663</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000663</idno>
<idno type="wicri:doubleKey">0006-8950:2009:Nandhagopal R:longitudinal:progression:of</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R." last="Nandhagopal">R. Nandhagopal</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuramoto, L" sort="Kuramoto, L" uniqKey="Kuramoto L" first="L." last="Kuramoto">L. Kuramoto</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cragg, J" sort="Cragg, J" uniqKey="Cragg J" first="J." last="Cragg">J. Cragg</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Chong S" sort="Lee, Chong S" uniqKey="Lee C" first="Chong S." last="Lee">Chong S. Lee</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mckenzie, J" sort="Mckenzie, J" uniqKey="Mckenzie J" first="J." last="Mckenzie">J. Mckenzie</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, University of Washington, Seattle</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName><settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccormick, S" sort="Mccormick, S" uniqKey="Mccormick S" first="S." last="Mccormick">S. Mccormick</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A." last="Samii">A. Samii</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, University of Washington, Seattle</wicri:regionArea>
<orgName type="university">Université de Washington</orgName>
<placeName><settlement type="city">Seattle</settlement>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T. J." last="Ruth">T. J. Ruth</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>3 TRIUMF, Wesbrook Mall, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sossi, V" sort="Sossi, V" uniqKey="Sossi V" first="V." last="Sossi">V. Sossi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>4 Department of Physics & Astronomy, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R." last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>1 Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
</author>
</analytic>
<series><idno type="ISSN">0006-8950</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Parkinson's disease is a heterogeneous disorder with multiple factors contributing to disease initiation and progression. Using serial, multi-tracer positron emission tomography imaging, we studied a cohort of 78 subjects with sporadic Parkinson's disease to understand the disease course better. Subjects were scanned with radiotracers of presynaptic dopaminergic integrity at baseline and again after 4 and 8 years of follow-up. Non-linear multivariate regression analyses, using random effects, of the form BPND(t) or Kocc(t) ae(btdA) c, where BPND tracer binding potential (nondispaceable), KOCC tracer uptake constant a, b, c and d are regression parameters, t is the symptom duration and A is the age at onset, were utilized to model the longitudinal progression of radiotracer binding/uptake. We found that the initial tracer binding/uptake was significantly different in anterior versus posterior striatal subregions, indicating that the degree of denervation at disease onset was different between regions. However, the relative rate of decline in tracer binding/uptake was similar between the striatal subregions. While an antero-posterior gradient of severity was maintained for dopamine synthesis, storage and reuptake, the asymmetry between the more and less affected striatum became less prominent over the disease course. Our study suggests that the mechanisms underlying Parkinson's disease initiation and progression are probably different. Whereas factors responsible for disease initiation affect striatal subregions differently, those factors contributing to disease progression affect all striatal subregions to a similar degree and may therefore reflect non-specific mechanisms such as oxidative stress, inflammation or excitotoxicity.</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study.</title>
<author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R" last="Nandhagopal">R. Nandhagopal</name>
<affiliation><nlm:affiliation>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC V6T2B5 Canada.</nlm:affiliation>
<wicri:noCountry code="subField">BC V6T2B5 Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kuramoto, L" sort="Kuramoto, L" uniqKey="Kuramoto L" first="L" last="Kuramoto">L. Kuramoto</name>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M" last="Schulzer">M. Schulzer</name>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E" last="Mak">E. Mak</name>
</author>
<author><name sortKey="Cragg, J" sort="Cragg, J" uniqKey="Cragg J" first="J" last="Cragg">J. Cragg</name>
</author>
<author><name sortKey="Lee, Chong S" sort="Lee, Chong S" uniqKey="Lee C" first="Chong S" last="Lee">Chong S. Lee</name>
</author>
<author><name sortKey="Mckenzie, J" sort="Mckenzie, J" uniqKey="Mckenzie J" first="J" last="Mckenzie">J. Mckenzie</name>
</author>
<author><name sortKey="Mccormick, S" sort="Mccormick, S" uniqKey="Mccormick S" first="S" last="Mccormick">S. Mccormick</name>
</author>
<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A" last="Samii">A. Samii</name>
</author>
<author><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A" last="Troiano">A. Troiano</name>
</author>
<author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T J" last="Ruth">T J Ruth</name>
</author>
<author><name sortKey="Sossi, V" sort="Sossi, V" uniqKey="Sossi V" first="V" last="Sossi">V. Sossi</name>
</author>
<author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R" last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name>
</author>
<author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B" last="Calne">Donald B. Calne</name>
</author>
<author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A J" last="Stoessl">A J Stoessl</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="RBID">pubmed:19690093</idno>
<idno type="pmid">19690093</idno>
<idno type="doi">10.1093/brain/awp209</idno>
<idno type="wicri:Area/PubMed/Corpus">000E22</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E22</idno>
<idno type="wicri:Area/PubMed/Curation">000E22</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E22</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000E22</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E22</idno>
<idno type="wicri:Area/Ncbi/Merge">000B32</idno>
<idno type="wicri:Area/Ncbi/Curation">000B32</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B32</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study.</title>
<author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R" last="Nandhagopal">R. Nandhagopal</name>
<affiliation><nlm:affiliation>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC V6T2B5 Canada.</nlm:affiliation>
<wicri:noCountry code="subField">BC V6T2B5 Canada</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kuramoto, L" sort="Kuramoto, L" uniqKey="Kuramoto L" first="L" last="Kuramoto">L. Kuramoto</name>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M" last="Schulzer">M. Schulzer</name>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E" last="Mak">E. Mak</name>
</author>
<author><name sortKey="Cragg, J" sort="Cragg, J" uniqKey="Cragg J" first="J" last="Cragg">J. Cragg</name>
</author>
<author><name sortKey="Lee, Chong S" sort="Lee, Chong S" uniqKey="Lee C" first="Chong S" last="Lee">Chong S. Lee</name>
</author>
<author><name sortKey="Mckenzie, J" sort="Mckenzie, J" uniqKey="Mckenzie J" first="J" last="Mckenzie">J. Mckenzie</name>
</author>
<author><name sortKey="Mccormick, S" sort="Mccormick, S" uniqKey="Mccormick S" first="S" last="Mccormick">S. Mccormick</name>
</author>
<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A" last="Samii">A. Samii</name>
</author>
<author><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A" last="Troiano">A. Troiano</name>
</author>
<author><name sortKey="Ruth, T J" sort="Ruth, T J" uniqKey="Ruth T" first="T J" last="Ruth">T J Ruth</name>
</author>
<author><name sortKey="Sossi, V" sort="Sossi, V" uniqKey="Sossi V" first="V" last="Sossi">V. Sossi</name>
</author>
<author><name sortKey="De La Fuente Fernandez, R" sort="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R" first="R" last="De La Fuente-Fernandez">R. De La Fuente-Fernandez</name>
</author>
<author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B" last="Calne">Donald B. Calne</name>
</author>
<author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A J" last="Stoessl">A J Stoessl</name>
</author>
</analytic>
<series><title level="j">Brain : a journal of neurology</title>
<idno type="eISSN">1460-2156</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Caudate Nucleus (diagnostic imaging)</term>
<term>Caudate Nucleus (metabolism)</term>
<term>Caudate Nucleus (pathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Patient Dropouts</term>
<term>Positron-Emission Tomography</term>
<term>Putamen (diagnostic imaging)</term>
<term>Putamen (metabolism)</term>
<term>Putamen (pathology)</term>
<term>Radiopharmaceuticals (metabolism)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Caudate Nucleus</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Caudate Nucleus</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Caudate Nucleus</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Patient Dropouts</term>
<term>Positron-Emission Tomography</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is a heterogeneous disorder with multiple factors contributing to disease initiation and progression. Using serial, multi-tracer positron emission tomography imaging, we studied a cohort of 78 subjects with sporadic Parkinson's disease to understand the disease course better. Subjects were scanned with radiotracers of presynaptic dopaminergic integrity at baseline and again after 4 and 8 years of follow-up. Non-linear multivariate regression analyses, using random effects, of the form BP(ND)(t) or K(occ)(t) = a*e((-)(bt)(-d)(A) + c, where BP(ND) = tracer binding potential (nondispaceable), K(OCC) = tracer uptake constant a, b, c and d are regression parameters, t is the symptom duration and A is the age at onset, were utilized to model the longitudinal progression of radiotracer binding/uptake. We found that the initial tracer binding/uptake was significantly different in anterior versus posterior striatal subregions, indicating that the degree of denervation at disease onset was different between regions. However, the relative rate of decline in tracer binding/uptake was similar between the striatal subregions. While an antero-posterior gradient of severity was maintained for dopamine synthesis, storage and reuptake, the asymmetry between the more and less affected striatum became less prominent over the disease course. Our study suggests that the mechanisms underlying Parkinson's disease initiation and progression are probably different. Whereas factors responsible for disease initiation affect striatal subregions differently, those factors contributing to disease progression affect all striatal subregions to a similar degree and may therefore reflect non-specific mechanisms such as oxidative stress, inflammation or excitotoxicity.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002042 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002042 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:54BBA92A9A3E58370CF3C12ED2373CE9525D23EB |texte= Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study }}
This area was generated with Dilib version V0.6.29. |