Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain
Identifieur interne : 001D05 ( Main/Merge ); précédent : 001D04; suivant : 001D06Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain
Auteurs : Francis Beaudry [Canada] ; Andréanne Ross [Canada] ; Pablo Patricio Lema [Canada] ; Pascal Vachon [Canada]Source :
- Phytotherapy Research [ 0951-418X ] ; 2010-04.
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Abstract
The analgesic effects of vanillin on neuropathic pain was evaluated using thermal sensitivity and mechanical allodynia using the sciatic nerve constriction model (n = 30 rats). To determine the pharmacokinetics of vanillin, rats (n = 6/administration route) received either 20 or 100 mg/kg of vanillin i.v. and p.o., respectively. For the pharmacodynamic study, baseline levels for hyperalgesia and allodynia were taken for 5 days prior to surgery. Following surgery each group (n = 6 rats/group) received either vanillin (50 mg/kg or 100 mg/kg), morphine (2 mg/kg or 6 mg/kg) or the vehicle only. Pharmacokinetic results following p.o. administrations are Cmax 290.24 ng/mL, Tmax 4 h, relative clearance 62.17 L/h/kg and T1/2 10.3 h. The bioavailability is 7.6%. Mechanical allodynia was decreased on treatment days 1, 2, 3, 5 (p < 0.003) and not on day 4 (p > 0.02) with 50 mg/kg vanillin, whereas at 100 mg/kg p.o. a decrease was noted only on days 7 and 8 (p < 0.003). No effect on hyperalgesia was seen following vanillin administration. In conclusion, vanillin is bioavailable and seems to have an alleviating effect on mechanical allodynia, and not on hyperalgesia, when evaluated with a chronic constriction nerve injury rat model of neuropathic pain. Copyright © 2009 John Wiley & Sons, Ltd.
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DOI: 10.1002/ptr.2975
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain</title><author><name sortKey="Beaudry, Francis" sort="Beaudry, Francis" uniqKey="Beaudry F" first="Francis" last="Beaudry">Francis Beaudry</name></author><author><name sortKey="Ross, Andreanne" sort="Ross, Andreanne" uniqKey="Ross A" first="Andréanne" last="Ross">Andréanne Ross</name></author><author><name sortKey="Lema, Pablo Patricio" sort="Lema, Pablo Patricio" uniqKey="Lema P" first="Pablo Patricio" last="Lema">Pablo Patricio Lema</name></author><author><name sortKey="Vachon, Pascal" sort="Vachon, Pascal" uniqKey="Vachon P" first="Pascal" last="Vachon">Pascal Vachon</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B49476264C36A83BAEC549863D45BECCEFAAED42</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/ptr.2975</idno><idno type="url">https://api-v5.istex.fr/document/B49476264C36A83BAEC549863D45BECCEFAAED42/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B81</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B81</idno><idno type="wicri:Area/Istex/Curation">001B81</idno><idno type="wicri:Area/Istex/Checkpoint">000578</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000578</idno><idno type="wicri:doubleKey">0951-418X:2010:Beaudry F:pharmacokinetics:of:vanillin</idno><idno type="wicri:Area/Main/Merge">001D05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain</title><author><name sortKey="Beaudry, Francis" sort="Beaudry, Francis" uniqKey="Beaudry F" first="Francis" last="Beaudry">Francis Beaudry</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal, Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, Saint‐Hyacinthe, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Andreanne" sort="Ross, Andreanne" uniqKey="Ross A" first="Andréanne" last="Ross">Andréanne Ross</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal, Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, Saint‐Hyacinthe, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Lema, Pablo Patricio" sort="Lema, Pablo Patricio" uniqKey="Lema P" first="Pablo Patricio" last="Lema">Pablo Patricio Lema</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal, Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, Saint‐Hyacinthe, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Vachon, Pascal" sort="Vachon, Pascal" uniqKey="Vachon P" first="Pascal" last="Vachon">Pascal Vachon</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal, Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, Saint‐Hyacinthe, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte, Saint‐Hyacinthe, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Phytotherapy Research</title><title level="j" type="sub">An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives</title><title level="j" type="abbrev">Phytother. Res.</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-04">2010-04</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="525">525</biblScope><biblScope unit="page" to="530">530</biblScope></imprint><idno type="ISSN">0951-418X</idno></series><idno type="istex">B49476264C36A83BAEC549863D45BECCEFAAED42</idno><idno type="DOI">10.1002/ptr.2975</idno><idno type="ArticleID">PTR2975</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>allodynia</term><term>neuropathic pain</term><term>pharmacokinetics</term><term>rats</term><term>vanillin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The analgesic effects of vanillin on neuropathic pain was evaluated using thermal sensitivity and mechanical allodynia using the sciatic nerve constriction model (n = 30 rats). To determine the pharmacokinetics of vanillin, rats (n = 6/administration route) received either 20 or 100 mg/kg of vanillin i.v. and p.o., respectively. For the pharmacodynamic study, baseline levels for hyperalgesia and allodynia were taken for 5 days prior to surgery. Following surgery each group (n = 6 rats/group) received either vanillin (50 mg/kg or 100 mg/kg), morphine (2 mg/kg or 6 mg/kg) or the vehicle only. Pharmacokinetic results following p.o. administrations are Cmax 290.24 ng/mL, Tmax 4 h, relative clearance 62.17 L/h/kg and T1/2 10.3 h. The bioavailability is 7.6%. Mechanical allodynia was decreased on treatment days 1, 2, 3, 5 (p < 0.003) and not on day 4 (p > 0.02) with 50 mg/kg vanillin, whereas at 100 mg/kg p.o. a decrease was noted only on days 7 and 8 (p < 0.003). No effect on hyperalgesia was seen following vanillin administration. In conclusion, vanillin is bioavailable and seems to have an alleviating effect on mechanical allodynia, and not on hyperalgesia, when evaluated with a chronic constriction nerve injury rat model of neuropathic pain. Copyright © 2009 John Wiley & Sons, Ltd.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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