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Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD(e–Pub ahead of print)

Identifieur interne : 001B68 ( Main/Merge ); précédent : 001B67; suivant : 001B69

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD(e–Pub ahead of print)

Auteurs : T. Van Eimeren ; G. Pellecchia ; R. Cilia ; B. Ballanger ; T. D. L. Steeves ; S. Houle ; J. M. Miyasaki ; M. Zurowski ; A. E. Lang ; A. P. Strafella

Source :

Neurology [ 0028-3878 ] ; 2010.

RBID : PMC:3033606

English descriptors

KwdEn :
- Adult, Aged, Antiparkinson Agents (pharmacology), Dopamine Agonists (pharmacology), Frontal Lobe (drug effects), Frontal Lobe (physiology), Gambling (diagnosis), Gambling (psychology), Humans, Middle Aged, Nerve Net (drug effects), Nerve Net (physiology), Neural Inhibition (drug effects), Neural Inhibition (physiology), Parkinson Disease (diagnosis), Parkinson Disease (psychology), Photic Stimulation (methods), Positron-Emission Tomography (methods), Predictive Value of Tests.
MESH :
- chemical , pharmacology : Antiparkinson Agents, Dopamine Agonists.
- diagnosis : Gambling, Parkinson Disease.
- drug effects : Frontal Lobe, Nerve Net, Neural Inhibition.
- methods : Photic Stimulation, Positron-Emission Tomography.
- physiology : Frontal Lobe, Nerve Net, Neural Inhibition.
- psychology : Gambling, Parkinson Disease.
- Adult, Aged, Humans, Middle Aged, Predictive Value of Tests.

Abstract

Objective:

Some patients with Parkinson disease (PD) develop pathological gambling when treated with dopamine agonists (DAs). However, little is known about DA-induced changes in neuronal networks that may underpin this drug-induced change in behavior in vulnerable individuals. In this case-control study, we aimed to investigate DA-induced changes in brain activity that may differentiate patients with PD with DA-induced pathological gambling (gamblers) from patients with PD without such a history (controls).

Methods:

Following overnight withdrawal of antiparkinsonian medication, patients were studied with H₂¹⁵O PET before and after administration of DA (3 mg apomorphine) to measure changes in regional cerebral blood flow as an index of regional brain activity during a card selection game with probabilistic feedback.

Results:

We observed that the direction of DA-related activity change in brain areas that are implicated in impulse control and response inhibition (lateral orbitofrontal cortex, rostral cingulate zone, amygdala, external pallidum) distinguished gamblers from controls. DA significantly increased activity in these areas in controls, while gamblers showed a significant DA-induced reduction of activity.

Conclusions:

We propose that in vulnerable patients with PD, DAs produce an abnormal neuronal pattern that resembles those found in nonparkinsonian pathological gambling and drug addiction. DA-induced disruption of inhibitory key functions—outcome monitoring (rostral cingulate zone), acquisition and retention of negative action-outcome associations (amygdala and lateral orbitofrontal cortex)—together with restricted access of those areas to executive control (external pallidum)—may well explain loss of impulse control and response inhibition in vulnerable patients with PD, thereby fostering the development of pathological gambling.

GLOSSARY

ANOVA

= analysis of variance;

= dopamine agonist;

G-SAS

= Gambling Symptom Assessment Scale;

GPe

= external pallidum;

MNI

= Montréal Neurological Institute;

OFC

= orbitofrontal cortex;

= Parkinson disease;

rCBF

= regional cerebral blood flow;

RCZ

= rostral cingulated zone;

UPDRS

= Unified Parkinson's Disease Rating Scale.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033606

DOI: 10.1212/WNL.0b013e3181fc27fa
PubMed: 20926784
PubMed Central: 3033606

Links to Exploration step

PMC:3033606

Le document en format XML

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<term>Frontal Lobe (drug effects)</term>
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<term>Parkinson Disease</term>
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<term>Nerve Net</term>
<term>Neural Inhibition</term>
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<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>Some patients with Parkinson disease (PD) develop pathological gambling when treated with dopamine agonists (DAs). However, little is known about DA-induced changes in neuronal networks that may underpin this drug-induced change in behavior in vulnerable individuals. In this case-control study, we aimed to investigate DA-induced changes in brain activity that may differentiate patients with PD with DA-induced pathological gambling (gamblers) from patients with PD without such a history (controls).</p>
</sec>
<sec><title>Methods:</title>
<p>Following overnight withdrawal of antiparkinsonian medication, patients were studied with H<sub>2</sub>
<sup>15</sup>
O PET before and after administration of DA (3 mg apomorphine) to measure changes in regional cerebral blood flow as an index of regional brain activity during a card selection game with probabilistic feedback.</p>
</sec>
<sec><title>Results:</title>
<p>We observed that the direction of DA-related activity change in brain areas that are implicated in impulse control and response inhibition (lateral orbitofrontal cortex, rostral cingulate zone, amygdala, external pallidum) distinguished gamblers from controls. DA significantly increased activity in these areas in controls, while gamblers showed a significant DA-induced reduction of activity.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We propose that in vulnerable patients with PD, DAs produce an abnormal neuronal pattern that resembles those found in nonparkinsonian pathological gambling and drug addiction. DA-induced disruption of inhibitory key functions—outcome monitoring (rostral cingulate zone), acquisition and retention of negative action-outcome associations (amygdala and lateral orbitofrontal cortex)—together with restricted access of those areas to executive control (external pallidum)—may well explain loss of impulse control and response inhibition in vulnerable patients with PD, thereby fostering the development of pathological gambling.</p>
</sec>
<sec><title>GLOSSARY</title>
<def-list list-type="abr"><def-item><term><bold>ANOVA</bold>
</term>
<def><p> = analysis of variance; </p>
</def>
</def-item>
<def-item><term><bold>DA</bold>
</term>
<def><p> = dopamine agonist; </p>
</def>
</def-item>
<def-item><term><bold>G-SAS</bold>
</term>
<def><p> = Gambling Symptom Assessment Scale; </p>
</def>
</def-item>
<def-item><term><bold>GPe</bold>
</term>
<def><p> = external pallidum; </p>
</def>
</def-item>
<def-item><term><bold>MNI</bold>
</term>
<def><p> = Montréal Neurological Institute; </p>
</def>
</def-item>
<def-item><term><bold>OFC</bold>
</term>
<def><p> = orbitofrontal cortex; </p>
</def>
</def-item>
<def-item><term><bold>PD</bold>
</term>
<def><p> = Parkinson disease; </p>
</def>
</def-item>
<def-item><term><bold>rCBF</bold>
</term>
<def><p> = regional cerebral blood flow; </p>
</def>
</def-item>
<def-item><term><bold>RCZ</bold>
</term>
<def><p> = rostral cingulated zone; </p>
</def>
</def-item>
<def-item><term><bold>UPDRS</bold>
</term>
<def><p> = Unified Parkinson's Disease Rating Scale.</p>
</def>
</def-item>
</def-list>
</sec>
</div>
</front>
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La maladie de Parkinson au Canada (serveur d'exploration)

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD(e–Pub ahead of print)

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD(e–Pub ahead of print)

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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