Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson's Disease Rating Scale (UPDRS) in U.S. male veterans
Identifieur interne : 001B47 ( Main/Merge ); précédent : 001B46; suivant : 001B48Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson's Disease Rating Scale (UPDRS) in U.S. male veterans
Auteurs : Galit Kleiner-Fisman [Canada] ; Matthew B. Stern [États-Unis] ; David N. Fisman [Canada]Source :
- Health and Quality of Life Outcomes [ 1477-7525 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Deep Brain Stimulation, Disease Progression, Educational Status, Health Status, Humans, Male, Marital Status, Multivariate Analysis, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Philadelphia, Quality of Life, Self Care (standards), Severity of Illness Index, Subthalamic Nucleus, Veterans (statistics & numerical data).
- MESH :
- geographic : Philadelphia.
- physiopathology : Parkinson Disease.
- standards : Self Care.
- statistics & numerical data : Veterans.
- therapy : Parkinson Disease.
- Aged, Aged, 80 and over, Deep Brain Stimulation, Disease Progression, Educational Status, Health Status, Humans, Male, Marital Status, Multivariate Analysis, Quality of Life, Severity of Illness Index, Subthalamic Nucleus.
Abstract
To apply a scaled, preference-based measure to the evaluation of health-related quality of life (HRQoL) in Parkinson's disease (PD); to evaluate the relationship between disease-specific rating scales and estimated HRQoL; and to identify predictors of diminished HRQoL.
Scaled, preference-based measures of HRQoL ("utilities") serve as indices of impact of disease, and can be used to generate quality-adjusted estimates of survival for health-economic evaluations. Evaluation of utilities for PD and their correlation with standard rating scales have been limited.
Utilities were generated using the Health Utilities Index Mark III (HUI-III) on consecutive patients attending a PD Clinic between October 2003 and June 2006. Disease severity, medical, surgical (subthalamic nucleus deep brain stimulation (STN-DBS)), and demographic information were used as model covariates. Predictors of HUI-III utility scores were evaluated using the Wilxocon rank-sum test and linear regression models.
68 men with a diagnosis of PD and a mean age of 74.0 (SD 7.4) were included in the data analysis. Mean HUI-III utility at first visit was 0.45 (SD 0.33). In multivariable models, UPDRS-II score (r2 = 0.56, P < 0.001) was highly predictive of HRQoL. UPDRS-III was a weaker, but still significant, predictor of utility scores, even after adjustment for UPDRS-II (P = 0.01).
Poor self-care in PD reflected by worsening UPDRS-II scores is strongly correlated with low generic HRQoL. HUI-III-based health utilities display convergent validity with the UPDRS-II. These findings highlight the importance of measures of independence as determinants of HRQoL in PD, and will facilitate the utilization of existing UPDRS data into economic analyses of PD therapies.
Url:
DOI: 10.1186/1477-7525-8-91
PubMed: 20799993
PubMed Central: 2939643
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PMC:2939643Le document en format XML
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Stern</name><affiliation wicri:level="1"><nlm:aff id="I2">Parkinson Disease Research Education and Clinical Center (PADRECC), Philadelphia VA Medical Center, 3900 Woodland Ave, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson Disease Research Education and Clinical Center (PADRECC), Philadelphia VA Medical Center, 3900 Woodland Ave, Philadelphia, PA 19104</wicri:regionArea><wicri:noRegion>PA 19104</wicri:noRegion></affiliation></author><author><name sortKey="Fisman, David N" sort="Fisman, David N" uniqKey="Fisman D" first="David N" last="Fisman">David N. Fisman</name><affiliation wicri:level="4"><nlm:aff id="I3">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 3M7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 3M7</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20799993</idno><idno type="pmc">2939643</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939643</idno><idno type="RBID">PMC:2939643</idno><idno type="doi">10.1186/1477-7525-8-91</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000A01</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A01</idno><idno type="wicri:Area/Pmc/Curation">000A01</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A01</idno><idno type="wicri:Area/Pmc/Checkpoint">000A42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A42</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000D09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D09</idno><idno type="wicri:Area/PubMed/Curation">000D09</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D09</idno><idno type="wicri:Area/PubMed/Checkpoint">000D09</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D09</idno><idno type="wicri:Area/Ncbi/Merge">000D27</idno><idno type="wicri:Area/Ncbi/Curation">000D27</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D27</idno><idno type="wicri:Area/Main/Merge">001B47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson's Disease Rating Scale (UPDRS) in U.S. male veterans</title><author><name sortKey="Kleiner Fisman, Galit" sort="Kleiner Fisman, Galit" uniqKey="Kleiner Fisman G" first="Galit" last="Kleiner-Fisman">Galit Kleiner-Fisman</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Baycrest Geriatric Hospital, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, Baycrest Geriatric Hospital, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1</wicri:regionArea><wicri:noRegion>M6A 2E1</wicri:noRegion></affiliation></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew B" last="Stern">Matthew B. Stern</name><affiliation wicri:level="1"><nlm:aff id="I2">Parkinson Disease Research Education and Clinical Center (PADRECC), Philadelphia VA Medical Center, 3900 Woodland Ave, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson Disease Research Education and Clinical Center (PADRECC), Philadelphia VA Medical Center, 3900 Woodland Ave, Philadelphia, PA 19104</wicri:regionArea><wicri:noRegion>PA 19104</wicri:noRegion></affiliation></author><author><name sortKey="Fisman, David N" sort="Fisman, David N" uniqKey="Fisman D" first="David N" last="Fisman">David N. Fisman</name><affiliation wicri:level="4"><nlm:aff id="I3">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 3M7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 3M7</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Health and Quality of Life Outcomes</title><idno type="eISSN">1477-7525</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Deep Brain Stimulation</term><term>Disease Progression</term><term>Educational Status</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Marital Status</term><term>Multivariate Analysis</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Philadelphia</term><term>Quality of Life</term><term>Self Care (standards)</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus</term><term>Veterans (statistics & numerical data)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Philadelphia</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Self Care</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Veterans</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Deep Brain Stimulation</term><term>Disease Progression</term><term>Educational Status</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Marital Status</term><term>Multivariate Analysis</term><term>Quality of Life</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To apply a scaled, preference-based measure to the evaluation of health-related quality of life (HRQoL) in Parkinson's disease (PD); to evaluate the relationship between disease-specific rating scales and estimated HRQoL; and to identify predictors of diminished HRQoL.</p></sec><sec><title>Background</title><p>Scaled, preference-based measures of HRQoL ("utilities") serve as indices of impact of disease, and can be used to generate quality-adjusted estimates of survival for health-economic evaluations. Evaluation of utilities for PD and their correlation with standard rating scales have been limited.</p></sec><sec><title>Methods</title><p>Utilities were generated using the Health Utilities Index Mark III (HUI-III) on consecutive patients attending a PD Clinic between October 2003 and June 2006. Disease severity, medical, surgical (subthalamic nucleus deep brain stimulation (STN-DBS)), and demographic information were used as model covariates. Predictors of HUI-III utility scores were evaluated using the Wilxocon rank-sum test and linear regression models.</p></sec><sec><title>Results</title><p>68 men with a diagnosis of PD and a mean age of 74.0 (SD 7.4) were included in the data analysis. Mean HUI-III utility at first visit was 0.45 (SD 0.33). In multivariable models, UPDRS-II score (r<sup>2 </sup>= 0.56, P < 0.001) was highly predictive of HRQoL. UPDRS-III was a weaker, but still significant, predictor of utility scores, even after adjustment for UPDRS-II (P = 0.01).</p></sec><sec><title>Conclusions</title><p>Poor self-care in PD reflected by worsening UPDRS-II scores is strongly correlated with low generic HRQoL. HUI-III-based health utilities display convergent validity with the UPDRS-II. These findings highlight the importance of measures of independence as determinants of HRQoL in PD, and will facilitate the utilization of existing UPDRS data into economic analyses of PD therapies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Lozano, Am" uniqKey="Lozano A">AM Lozano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirtz, D" uniqKey="Hirtz D">D Hirtz</name></author><author><name sortKey="Thurman, Dj" uniqKey="Thurman D">DJ Thurman</name></author><author><name sortKey="Gwinn Hardy, K" uniqKey="Gwinn Hardy K">K Gwinn-Hardy</name></author><author><name sortKey="Mohamed, M" uniqKey="Mohamed M">M Mohamed</name></author><author><name sortKey="Chaudhuri, Ar" uniqKey="Chaudhuri A">AR Chaudhuri</name></author><author><name sortKey="Zalutsky, R" uniqKey="Zalutsky R">R 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uniqKey="Mokdad A">AH Mokdad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slawek, J" uniqKey="Slawek J">J Slawek</name></author><author><name sortKey="Derejko, M" uniqKey="Derejko M">M Derejko</name></author><author><name sortKey="Lass, P" uniqKey="Lass P">P Lass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuopio, Am" uniqKey="Kuopio A">AM Kuopio</name></author><author><name sortKey="Marttila, Rj" uniqKey="Marttila R">RJ Marttila</name></author><author><name sortKey="Helenius, H" uniqKey="Helenius H">H Helenius</name></author><author><name sortKey="Toivonen, M" uniqKey="Toivonen M">M Toivonen</name></author><author><name sortKey="Rinne, Uk" uniqKey="Rinne U">UK Rinne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Rumayor, A" uniqKey="Martinez Rumayor A">A Martinez-Rumayor</name></author><author><name sortKey="Arrieta, O" uniqKey="Arrieta O">O Arrieta</name></author><author><name sortKey="Sotelo, J" uniqKey="Sotelo J">J Sotelo</name></author><author><name sortKey="Garcia, E" uniqKey="Garcia E">E Garcia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uc, Ey" uniqKey="Uc E">EY Uc</name></author><author><name sortKey="Mcdermott, Mp" uniqKey="Mcdermott M">MP McDermott</name></author><author><name sortKey="Marder, Ks" uniqKey="Marder K">KS Marder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siri, C" uniqKey="Siri C">C Siri</name></author><author><name sortKey="Cilia, R" uniqKey="Cilia R">R Cilia</name></author><author><name sortKey="De, Gd" uniqKey="De G">GD De</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riedel, O" uniqKey="Riedel O">O Riedel</name></author><author><name sortKey="Heuser, I" uniqKey="Heuser I">I Heuser</name></author><author><name sortKey="Klotsche, J" uniqKey="Klotsche J">J Klotsche</name></author><author><name sortKey="Dodel, R" uniqKey="Dodel R">R Dodel</name></author><author><name sortKey="Ittchen, Hu" uniqKey="Ittchen H">HU ittchen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulman, Lm" uniqKey="Shulman L">LM Shulman</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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