Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study
Identifieur interne : 001590 ( Main/Merge ); précédent : 001589; suivant : 001591Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study
Auteurs : Julia Sacher [Canada, Allemagne] ; Eugenii A. Rabiner [Canada] ; Michael Clark [Canada] ; Pablo Rusjan [Canada] ; Alexandra Soliman [Canada] ; Rada Boskovic [Canada] ; Stephen J. Kish [Canada] ; Alan A. Wilson [Canada] ; Sylvain Houle [Canada] ; Jeffrey H. Meyer [Canada]Source :
- Journal of cerebral blood flow and metabolism [ 0271-678X ] ; 2012.
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Abstract
Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14% ±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa-levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [<sup>11</sup>C]-harmine positron emission tomography study</title><author><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Day Clinic of Cognitive Neurology, University of Leipzig and Max-Planck-Institute for Cognition and Brain Sciences</s1><s2>Leipzig</s2><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Rabiner, Eugenii A" sort="Rabiner, Eugenii A" uniqKey="Rabiner E" first="Eugenii A." last="Rabiner">Eugenii A. 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Meyer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0176670</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0176670 INIST</idno><idno type="RBID">Pascal:12-0176670</idno><idno type="wicri:Area/PascalFrancis/Corpus">000210</idno><idno type="wicri:Area/PascalFrancis/Curation">000A42</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000176</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000176</idno><idno type="wicri:doubleKey">0271-678X:2012:Sacher J:dynamic:adaptive:changes</idno><idno type="wicri:Area/Main/Merge">001590</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [<sup>11</sup>C]-harmine positron emission tomography study</title><author><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Day Clinic of Cognitive Neurology, University of Leipzig and Max-Planck-Institute for Cognition and Brain Sciences</s1><s2>Leipzig</s2><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Rabiner, Eugenii A" sort="Rabiner, Eugenii A" uniqKey="Rabiner E" first="Eugenii A." last="Rabiner">Eugenii A. Rabiner</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>GlaxoSmithKline</s1><s2>Toronto</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>GlaxoSmithKline</wicri:noRegion></affiliation></author><author><name sortKey="Clark, Michael" sort="Clark, Michael" uniqKey="Clark M" first="Michael" last="Clark">Michael Clark</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation></author><author><name sortKey="Soliman, Alexandra" sort="Soliman, Alexandra" uniqKey="Soliman A" first="Alexandra" last="Soliman">Alexandra Soliman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>GlaxoSmithKline</s1><s2>Toronto</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>GlaxoSmithKline</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>The Clinical Pharmacology and Toxicology Division, The Hospital for Sick Children, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vivian M Rakoff PET Imaging Centre</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vivian M Rakoff PET Imaging Centre</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of cerebral blood flow and metabolism</title><title level="j" type="abbreviated">J. cereb. blood flow metab.</title><idno type="ISSN">0271-678X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of cerebral blood flow and metabolism</title><title level="j" type="abbreviated">J. cereb. blood flow metab.</title><idno type="ISSN">0271-678X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrovascular disease</term><term>Depression</term><term>Dopamine</term><term>Emission tomography</term><term>Encephalon</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Pathologie cérébrovasculaire</term><term>Etat dépressif</term><term>Maladie de Parkinson</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term><term>Encéphale</term><term>Dopamine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [<sup>11</sup>C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A V<sub>T</sub>, an index of MAO-A density, was decreased (mean: 14% ±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa-levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>District de Leipzig</li><li>Ontario</li><li>Saxe (Land)</li></region><settlement><li>Leipzig</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name></noRegion><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><name sortKey="Clark, Michael" sort="Clark, Michael" uniqKey="Clark M" first="Michael" last="Clark">Michael Clark</name><name sortKey="Clark, Michael" sort="Clark, Michael" uniqKey="Clark M" first="Michael" last="Clark">Michael Clark</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name><name sortKey="Rabiner, Eugenii A" sort="Rabiner, Eugenii A" uniqKey="Rabiner E" first="Eugenii A." last="Rabiner">Eugenii A. Rabiner</name><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name><name sortKey="Soliman, Alexandra" sort="Soliman, Alexandra" uniqKey="Soliman A" first="Alexandra" last="Soliman">Alexandra Soliman</name><name sortKey="Soliman, Alexandra" sort="Soliman, Alexandra" uniqKey="Soliman A" first="Alexandra" last="Soliman">Alexandra Soliman</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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