N-Methyl-D-Aspartate antagonists in levodopa induced dyskinesia: a meta-analysis.
Identifieur interne : 001197 ( Main/Merge ); précédent : 001196; suivant : 001198N-Methyl-D-Aspartate antagonists in levodopa induced dyskinesia: a meta-analysis.
Auteurs : Behzad Elahi [Canada] ; Nicolás Phielipp ; Robert ChenSource :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [ 0317-1671 ] ; 2012.
English descriptors
- KwdEn :
- Amantadine (therapeutic use), Databases, Factual (statistics & numerical data), Disability Evaluation, Double-Blind Method, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (prevention & control), Excitatory Amino Acid Antagonists (therapeutic use), Humans, Levodopa (adverse effects), Parkinson Disease (drug therapy), Randomized Controlled Trials as Topic, Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors), Severity of Illness Index.
- MESH :
- chemical , adverse effects : Levodopa.
- chemical , antagonists & inhibitors : Receptors, N-Methyl-D-Aspartate.
- chemical , therapeutic use : Amantadine, Excitatory Amino Acid Antagonists.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- prevention & control : Dyskinesia, Drug-Induced.
- statistics & numerical data : Databases, Factual.
- Disability Evaluation, Double-Blind Method, Humans, Randomized Controlled Trials as Topic, Severity of Illness Index.
Abstract
Levodopa-induced dyskinesias (LID) are amongst the most disabling side-effects of levodopa therapy for Parkinson's disease (PD). It has been suggested that that N-Methyl-D-Aspartate (NMDA)-receptor antagonist may reduce peak-dose dyskinesia in PD patients and may lead to motor improvement. In this study, we compared the efficacy of NMDA receptor antagonists versus placebo in the treatment of LID in PD through a meta-analysis of controlled trials.
PubMed: 22728853
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pubmed:22728853Le document en format XML
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Le journal canadien des sciences neurologiques</title><idno type="ISSN">0317-1671</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amantadine (therapeutic use)</term><term>Databases, Factual (statistics & numerical data)</term><term>Disability Evaluation</term><term>Double-Blind Method</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (prevention & control)</term><term>Excitatory Amino Acid Antagonists (therapeutic use)</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Parkinson Disease (drug therapy)</term><term>Randomized Controlled Trials as Topic</term><term>Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptors, N-Methyl-D-Aspartate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amantadine</term><term>Excitatory Amino Acid Antagonists</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Factual</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disability Evaluation</term><term>Double-Blind Method</term><term>Humans</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa-induced dyskinesias (LID) are amongst the most disabling side-effects of levodopa therapy for Parkinson's disease (PD). It has been suggested that that N-Methyl-D-Aspartate (NMDA)-receptor antagonist may reduce peak-dose dyskinesia in PD patients and may lead to motor improvement. In this study, we compared the efficacy of NMDA receptor antagonists versus placebo in the treatment of LID in PD through a meta-analysis of controlled trials.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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