NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges
Identifieur interne : 000E89 ( Main/Merge ); précédent : 000E88; suivant : 000E90NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges
Auteurs : Rima Slim [Canada] ; Evan P. Wallace [Canada]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2013.
Abstract
NOD-like receptor proteins (
Url:
DOI: 10.3389/fimmu.2013.00242
PubMed: 23970884
PubMed Central: 3747449
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PMC:3747449Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>NLRP7</italic> and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges</title><author><name sortKey="Slim, Rima" sort="Slim, Rima" uniqKey="Slim R" first="Rima" last="Slim">Rima Slim</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Human Genetics, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Obstetrics and Gynecology, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallace, Evan P" sort="Wallace, Evan P" uniqKey="Wallace E" first="Evan P." last="Wallace">Evan P. Wallace</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Human Genetics, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Obstetrics and Gynecology, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23970884</idno><idno type="pmc">3747449</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747449</idno><idno type="RBID">PMC:3747449</idno><idno type="doi">10.3389/fimmu.2013.00242</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000C19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C19</idno><idno type="wicri:Area/Pmc/Curation">000C19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C19</idno><idno type="wicri:Area/Pmc/Checkpoint">000729</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000729</idno><idno type="wicri:Area/Ncbi/Merge">001547</idno><idno type="wicri:Area/Ncbi/Curation">001547</idno><idno type="wicri:Area/Ncbi/Checkpoint">001547</idno><idno type="wicri:Area/Main/Merge">000E89</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>NLRP7</italic> and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges</title><author><name sortKey="Slim, Rima" sort="Slim, Rima" uniqKey="Slim R" first="Rima" last="Slim">Rima Slim</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Human Genetics, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Obstetrics and Gynecology, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallace, Evan P" sort="Wallace, Evan P" uniqKey="Wallace E" first="Evan P." last="Wallace">Evan P. Wallace</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Human Genetics, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Obstetrics and Gynecology, McGill University Health Centre</institution>,<addr-line>Montreal, QC</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>NOD-like receptor proteins (<italic>NLRPs</italic>) are emerging key players in several inflammatory pathways in Mammals. The first identified gene coding for a protein from this family is <italic>Nlrp5</italic> and was originally called <italic>Mater</italic> for “Maternal Antigen That Mouse Embryos Require” for normal development beyond the two-cell stage. This important discovery was followed by the identification of other <italic>NLRP</italic>s playing roles in inflammatory disorders and of the first maternal-effect gene in humans, <italic>NLRP7</italic>, which is responsible for an aberrant form of human pregnancy called hydatidiform mole (HM). In this review, we recapitulate the various aspects of the pathology of HM, highlight recent advances regarding <italic>NLRP7</italic> and its role in HM and related forms of reproductive losses, and expand our discussion to other <italic>NLRP</italic>s with a special emphasis on those with known roles in mammalian reproduction. Our aim is to facilitate the genetic complexity of recurrent fetal loss in humans and encourage interdisciplinary collaborations in the fields of <italic>NLRP</italic>s and reproductive loss.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brews, A" uniqKey="Brews A">A Brews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ricci, Jv" uniqKey="Ricci J">JV Ricci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Trommel, Ne" uniqKey="Van Trommel N">NE van Trommel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savage, P" uniqKey="Savage P">P Savage</name></author><author><name sortKey="Williams, J" uniqKey="Williams J">J Williams</name></author><author><name sortKey="Wong, Sl" uniqKey="Wong S">SL Wong</name></author><author><name sortKey="Short, D" uniqKey="Short D">D Short</name></author><author><name sortKey="Casalboni, S" 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uniqKey="Guo Z">ZK Guo</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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