ParkinsonCanadaV1, Main, Merge, bibRecord, 000E74

Affective disorders in Parkinson’s disease

Identifieur interne : 000E74 ( Main/Merge ); précédent : 000E73; suivant : 000E75

Affective disorders in Parkinson’s disease

Auteurs : Kelly S. G. Aminian [Canada] ; Antonio P. Strafella [Canada]

Source :

Current opinion in neurology [ 1350-7540 ] ; 2013.

RBID : PMC:4452223

English descriptors

KwdEn :
- Awareness, Brain (pathology), Humans, Mood Disorders (etiology), Mood Disorders (pathology), Neuroimaging, Parkinson Disease (complications).
MESH :
- complications : Parkinson Disease.
- etiology : Mood Disorders.
- pathology : Brain, Mood Disorders.
- Awareness, Humans, Neuroimaging.

Abstract

Purpose of review

This review explores recent literature pertaining to affective disorders associated with Parkinson’s disease.

Recent findings

Nonmotor symptoms including affective disorders are becoming more widely recognized as complications of Parkinson’s disease. As awareness of these symptoms increases, and new neuroimaging tools are developed and become more accessible, more studies are being conducted pertaining to behavioral complications in Parkinson’s disease. The functional connectivity of the basal ganglia can predispose people with Parkinson’s to develop affective disorders. Furthermore, dopaminergic treatments may exacerbate or trigger behavioral symptoms. It is now understood that changes associated with Parkinson’s disease are widespread, affecting striatal and extrastriatal regions and resulting in alterations in gray matter, white matter, blood flow, metabolism, and dopaminergic and serotonergic function.

Summary

Neuroimaging is advancing our knowledge of the mechanisms involved in Parkinson’s disease, and their role in the development of behavioral disorders. An increased understanding of these disorders may lead to the discovery of new therapeutic targets, or the identification of risk factors for the development of these disorders. If preventive therapies become available, identification of risk factors will be important for the identification and treatment of susceptible individuals.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452223

DOI: 10.1097/WCO.0b013e328363304c
PubMed: 23757262
PubMed Central: 4452223

Links to Exploration step

PMC:4452223

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose of review</title>
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</sec>
<sec id="S2"><title>Recent findings</title>
<p id="P2">Nonmotor symptoms including affective disorders are becoming more widely recognized as complications of Parkinson’s disease. As awareness of these symptoms increases, and new neuroimaging tools are developed and become more accessible, more studies are being conducted pertaining to behavioral complications in Parkinson’s disease. The functional connectivity of the basal ganglia can predispose people with Parkinson’s to develop affective disorders. Furthermore, dopaminergic treatments may exacerbate or trigger behavioral symptoms. It is now understood that changes associated with Parkinson’s disease are widespread, affecting striatal and extrastriatal regions and resulting in alterations in gray matter, white matter, blood flow, metabolism, and dopaminergic and serotonergic function.</p>
</sec>
<sec id="S3"><title>Summary</title>
<p id="P3">Neuroimaging is advancing our knowledge of the mechanisms involved in Parkinson’s disease, and their role in the development of behavioral disorders. An increased understanding of these disorders may lead to the discovery of new therapeutic targets, or the identification of risk factors for the development of these disorders. If preventive therapies become available, identification of risk factors will be important for the identification and treatment of susceptible individuals.</p>
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La maladie de Parkinson au Canada (serveur d'exploration)

Affective disorders in Parkinson’s disease

Affective disorders in Parkinson’s disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.