Parkinson's Disease and Occupation: Differences in Associations by Case Identification Method Suggest Referral Bias
Identifieur interne : 000B93 ( Main/Merge ); précédent : 000B92; suivant : 000B94Parkinson's Disease and Occupation: Differences in Associations by Case Identification Method Suggest Referral Bias
Auteurs : Kay Teschke [Canada] ; Stephen A. Marion [Canada] ; Joseph K. C. Tsui [Canada] ; HUI SHEN [Canada] ; Kathrine Rugbjerg [Canada, Danemark] ; M. Anne Harris [Canada]Source :
- American journal of industrial medicine [ 0271-3586 ] ; 2014.
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Abstract
Methods We used a population-based sample of 403 Parkinson's disease cases and 405 controls to examine risks by occupation. Results were compared to a previous clinic-based analysis. Results With censoring of jobs held within 10 years of diagnosis, the following had significantly or strongly increased risks: social science, law and library jobs (OR = 1.8); farming and horticulture jobs (OR = 2.0); gas station jobs (OR = 2.6); and welders (OR = 3.0). The following had significantly decreased risks: management and administration jobs (OR = 0.70); and other health care jobs (OR = 0.44). Conclusions These results were consistent with other findings for social science and farming occupations. Risks for teaching, medicine and health occupations were not elevated, unlike our previous clinic-based study. This underscores the value of population-based over clinic-based samples. Occupational studies may be particularly susceptible to referral bias because social networks may spread preferentially via jobs.
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<term>Human</term>
<term>Identification</term>
<term>Methodological bias</term>
<term>Occupational exposure</term>
<term>Occupational medicine</term>
<term>Parkinson disease</term>
<term>Profession</term>
<term>Professional activity</term>
<term>Selection criterion</term>
<term>Socioeconomic category</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Profession</term>
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<term>Catégorie socioprofessionnelle</term>
<term>Activité professionnelle</term>
<term>Etude comparative</term>
<term>Homme</term>
<term>Maladie de Parkinson</term>
<term>Identification</term>
<term>Biais méthodologique</term>
<term>Exposition professionnelle</term>
<term>Médecine du travail</term>
<term>Critère sélection</term>
<term>Biais de sélection</term>
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<front><div type="abstract" xml:lang="en">Methods We used a population-based sample of 403 Parkinson's disease cases and 405 controls to examine risks by occupation. Results were compared to a previous clinic-based analysis. Results With censoring of jobs held within 10 years of diagnosis, the following had significantly or strongly increased risks: social science, law and library jobs (OR = 1.8); farming and horticulture jobs (OR = 2.0); gas station jobs (OR = 2.6); and welders (OR = 3.0). The following had significantly decreased risks: management and administration jobs (OR = 0.70); and other health care jobs (OR = 0.44). Conclusions These results were consistent with other findings for social science and farming occupations. Risks for teaching, medicine and health occupations were not elevated, unlike our previous clinic-based study. This underscores the value of population-based over clinic-based samples. Occupational studies may be particularly susceptible to referral bias because social networks may spread preferentially via jobs.</div>
</front>
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