A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration
Identifieur interne : 001738 ( Main/Exploration ); précédent : 001737; suivant : 001739A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration
Auteurs : Simon C. Spanswick [Canada] ; Hugo Lehmann [Canada] ; Robert J. Sutherland [Canada]Source :
- Journal of Biomedicine and Biotechnology [ 1110-7243 ] ; 2011.
Abstract
Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deficits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model. We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind.
Url:
DOI: 10.1155/2011/527201
PubMed: 21541187
PubMed Central: 3085481
Affiliations:
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Spanswick</name><affiliation wicri:level="4"><nlm:aff id="I1">Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Lehmann, Hugo" sort="Lehmann, Hugo" uniqKey="Lehmann H" first="Hugo" last="Lehmann">Hugo Lehmann</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Psychology, Trent University, 1600 West Bank Drive, Peterborough, ON, Canada K9J 7B8</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychology, Trent University, 1600 West Bank Drive, Peterborough, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Sutherland, Robert J" sort="Sutherland, Robert J" uniqKey="Sutherland R" first="Robert J." last="Sutherland">Robert J. 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Spanswick</name><affiliation wicri:level="4"><nlm:aff id="I1">Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Lehmann, Hugo" sort="Lehmann, Hugo" uniqKey="Lehmann H" first="Hugo" last="Lehmann">Hugo Lehmann</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Psychology, Trent University, 1600 West Bank Drive, Peterborough, ON, Canada K9J 7B8</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychology, Trent University, 1600 West Bank Drive, Peterborough, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Sutherland, Robert J" sort="Sutherland, Robert J" uniqKey="Sutherland R" first="Robert J." last="Sutherland">Robert J. Sutherland</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4</nlm:aff><country>Canada</country><wicri:regionArea>Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Biomedicine and Biotechnology</title><idno type="ISSN">1110-7243</idno><idno type="eISSN">1110-7251</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deficits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model. 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Sutherland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rai, Ks" uniqKey="Rai K">KS Rai</name></author><author><name sortKey="Hattiangady, B" uniqKey="Hattiangady B">B Hattiangady</name></author><author><name sortKey="Shetty, Ak" uniqKey="Shetty A">AK Shetty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahn, S" uniqKey="Ahn S">S Ahn</name></author><author><name sortKey="Joyner, Al" uniqKey="Joyner A">AL Joyner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palam, V" uniqKey="Palam V">V Palam</name></author><author><name sortKey="Lim, Da" uniqKey="Lim D">DA Lim</name></author><author><name sortKey="Dahmane, N" uniqKey="Dahmane N">N Dahmane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hicks, Rr" uniqKey="Hicks R">RR Hicks</name></author><author><name sortKey="Smith, Dh" uniqKey="Smith D">DH Smith</name></author><author><name sortKey="Lowenstein, Dh" uniqKey="Lowenstein D">DH Lowenstein</name></author><author><name sortKey="Saint Marie, R" uniqKey="Saint Marie R">R Saint Marie</name></author><author><name sortKey="Mcintosh, Tk" uniqKey="Mcintosh T">TK McIntosh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamaki, T" uniqKey="Yamaki T">T Yamaki</name></author><author><name sortKey="Murakami, N" uniqKey="Murakami N">N Murakami</name></author><author><name sortKey="Iwamoto, Y" uniqKey="Iwamoto Y">Y Iwamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huh, Jw" uniqKey="Huh J">JW Huh</name></author><author><name sortKey="Raghupathi, R" uniqKey="Raghupathi R">R Raghupathi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langdon, Kd" uniqKey="Langdon K">KD Langdon</name></author><author><name sortKey="Granter Button, S" uniqKey="Granter Button S">S Granter-Button</name></author><author><name sortKey="Corbett, D" uniqKey="Corbett D">D Corbett</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Spanswick, Simon C" sort="Spanswick, Simon C" uniqKey="Spanswick S" first="Simon C." last="Spanswick">Simon C. Spanswick</name></region><name sortKey="Lehmann, Hugo" sort="Lehmann, Hugo" uniqKey="Lehmann H" first="Hugo" last="Lehmann">Hugo Lehmann</name><name sortKey="Sutherland, Robert J" sort="Sutherland, Robert J" uniqKey="Sutherland R" first="Robert J." last="Sutherland">Robert J. Sutherland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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