Neurofilament cytoskeleton disruption does not modify accumulation of trophic factor mRNA
Identifieur interne : 003197 ( Main/Exploration ); précédent : 003196; suivant : 003198Neurofilament cytoskeleton disruption does not modify accumulation of trophic factor mRNA
Auteurs : Patrick Robert [France] ; Alan C. Peterson [Canada] ; Joël Eyer [France]Source :
- Journal of Neuroscience Research [ 0360-4012 ] ; 2001-06-01.
English descriptors
Abstract
Previously we described a transgenic mouse model in which neurofilaments are sequestered in neuronal cell bodies and withheld from the axonal compartment. This model and other transgenic models with disrupted neurofilaments are used widely to investigate the role of the neurofilament cytoskeleton in normal neurons and in inherited or acquired diseases. To interpret such studies, it is important to establish whether the maldistribution of neurofilaments has major secondary consequences on the cell biology of the affected neurons. Notably, multiple perturbations of the nervous system simultaneously affect both the neuronal cytoskeleton and neurotrophin expression. To determine whether the expression of neurotrophic factors or their receptors is perturbed by a primary disruption in neurofilaments, we compared the accumulated mRNA levels for ciliary neuroptrophic factor (CNTF), nerve growth factor, neurotrophin 3, and the α CNTF receptor in mature transgenic mice and their littermate controls. Consistently with the prolonged survival of neurons expressing atypical or abnormally distributed neurofilaments, no obvious changes were observed for any of the mRNA species examined. J. Neurosci. Res. 64:487–492, 2001. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jnr.1100
Affiliations:
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<front><div type="abstract" xml:lang="en">Previously we described a transgenic mouse model in which neurofilaments are sequestered in neuronal cell bodies and withheld from the axonal compartment. This model and other transgenic models with disrupted neurofilaments are used widely to investigate the role of the neurofilament cytoskeleton in normal neurons and in inherited or acquired diseases. To interpret such studies, it is important to establish whether the maldistribution of neurofilaments has major secondary consequences on the cell biology of the affected neurons. Notably, multiple perturbations of the nervous system simultaneously affect both the neuronal cytoskeleton and neurotrophin expression. To determine whether the expression of neurotrophic factors or their receptors is perturbed by a primary disruption in neurofilaments, we compared the accumulated mRNA levels for ciliary neuroptrophic factor (CNTF), nerve growth factor, neurotrophin 3, and the α CNTF receptor in mature transgenic mice and their littermate controls. Consistently with the prolonged survival of neurons expressing atypical or abnormally distributed neurofilaments, no obvious changes were observed for any of the mRNA species examined. J. Neurosci. Res. 64:487–492, 2001. © 2001 Wiley‐Liss, Inc.</div>
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