Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety
Identifieur interne : 004F61 ( Main/Exploration ); précédent : 004F60; suivant : 004F62Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety
Auteurs : Gideon Koren [Canada] ; Warwick Butt [Canada] ; Herbert Chinyanga [Canada] ; Steven Soldin [Canada] ; Yok-Kwang Tan [Canada] ; Karen Pape [Canada]Source :
- The Journal of Pediatrics [ 0022-3476 ] ; 1985.
Abstract
Twelve newborn infants were given morphine intravenously for postoperative analgesia. They received a continuous infusion of 6.2 to 40 μg/kg/hr for 9 to 105 hours (mean±SEM 59.5±10.2 hours); in four the infusion was preceded by a loading dose of 50 to 100 μg/kg. Morphine plasma concentrations correlated with the rate of infusion, but with large variability. There was a tendency for plasma morphine concentrations to decrease in some patients receiving a constant infusion rate, suggesting improvement in morphine clearance rate. Elimination half-life of morphine (13.9±6.4 hours) was significantly longer than in older children and adults (about 2 hours). Similarly, morphine concentrations in neonates receiving 20 μg/kg/hr for 24 hours were three times higher (52±31 ng/ml) than in older children receiving the same schedule. Two infants who received 32 and 40 μg/kg/hr, respectively, developed generalized seizures. Because of the apparently greater sensitivity to morphine and the lower elimination rate in newborn infant, the infused dose should not exceed 15 μg/kg/hr.
Url:
DOI: 10.1016/S0022-3476(85)80205-5
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001873
- to stream Istex, to step Curation: 001873
- to stream Istex, to step Checkpoint: 002533
- to stream Main, to step Merge: 005972
- to stream Main, to step Curation: 004F61
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety</title><author><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name></author><author><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name></author><author><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name></author><author><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name></author><author><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name></author><author><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6207B6E9B6E2981E25CE12C6ABBEF90A4D2B975B</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1016/S0022-3476(85)80205-5</idno><idno type="url">https://api-v5.istex.fr/document/6207B6E9B6E2981E25CE12C6ABBEF90A4D2B975B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001873</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001873</idno><idno type="wicri:Area/Istex/Curation">001873</idno><idno type="wicri:Area/Istex/Checkpoint">002533</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002533</idno><idno type="wicri:doubleKey">0022-3476:1985:Koren G:postoperative:morphine:infusion</idno><idno type="wicri:Area/Main/Merge">005972</idno><idno type="wicri:Area/Main/Curation">004F61</idno><idno type="wicri:Area/Main/Exploration">004F61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety</title><author><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Pharmacology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neonatology, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Reprint requests: Gideon Koren, M. D., Division of Clinical Pharmacology, The Hospital for Sick Children, 555 University Ave., Toronto, Ont.</wicri:regionArea><wicri:noRegion>Ont.</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Pharmacology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neonatology, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Pharmacology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neonatology, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Pharmacology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neonatology, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Pharmacology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neonatology, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Pharmacology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neonatology, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, The Research Institute, The Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Pediatrics</title><title level="j" type="abbrev">YMPD</title><idno type="ISSN">0022-3476</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">107</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="963">963</biblScope><biblScope unit="page" to="967">967</biblScope></imprint><idno type="ISSN">0022-3476</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3476</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Twelve newborn infants were given morphine intravenously for postoperative analgesia. They received a continuous infusion of 6.2 to 40 μg/kg/hr for 9 to 105 hours (mean±SEM 59.5±10.2 hours); in four the infusion was preceded by a loading dose of 50 to 100 μg/kg. Morphine plasma concentrations correlated with the rate of infusion, but with large variability. There was a tendency for plasma morphine concentrations to decrease in some patients receiving a constant infusion rate, suggesting improvement in morphine clearance rate. Elimination half-life of morphine (13.9±6.4 hours) was significantly longer than in older children and adults (about 2 hours). Similarly, morphine concentrations in neonates receiving 20 μg/kg/hr for 24 hours were three times higher (52±31 ng/ml) than in older children receiving the same schedule. Two infants who received 32 and 40 μg/kg/hr, respectively, developed generalized seizures. Because of the apparently greater sensitivity to morphine and the lower elimination rate in newborn infant, the infused dose should not exceed 15 μg/kg/hr.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name></noRegion><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name><name sortKey="Butt, Warwick" sort="Butt, Warwick" uniqKey="Butt W" first="Warwick" last="Butt">Warwick Butt</name><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name><name sortKey="Chinyanga, Herbert" sort="Chinyanga, Herbert" uniqKey="Chinyanga H" first="Herbert" last="Chinyanga">Herbert Chinyanga</name><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name><name sortKey="Pape, Karen" sort="Pape, Karen" uniqKey="Pape K" first="Karen" last="Pape">Karen Pape</name><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name><name sortKey="Soldin, Steven" sort="Soldin, Steven" uniqKey="Soldin S" first="Steven" last="Soldin">Steven Soldin</name><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name><name sortKey="Tan, Yok Kwang" sort="Tan, Yok Kwang" uniqKey="Tan Y" first="Yok-Kwang" last="Tan">Yok-Kwang Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004F61 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004F61 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:6207B6E9B6E2981E25CE12C6ABBEF90A4D2B975B
|texte= Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety
}}
| This area was generated with Dilib version V0.6.29. |  |