Human brain dopamine receptors in children and aging adults
Identifieur interne : 004D52 ( Main/Exploration ); précédent : 004D51; suivant : 004D53Human brain dopamine receptors in children and aging adults
Auteurs : Philip Seeman [Canada] ; Natalie H. Bzowej [Canada] ; H. Guan [République populaire de Chine] ; Catherine Bergeron [Canada] ; Lawrence E. Becker [Canada] ; Gavin P. Reynolds ; E. D. Bird [États-Unis] ; Peter Riederer [Autriche] ; Kurt Jellinger [Autriche] ; Shuzo Watanabe ; Wallace W. Tourtellotte [États-Unis]Source :
- Synapse [ 0887-4476 ] ; 1987.
English descriptors
- KwdEn :
Abstract
Since spontaneous oral dyskinesias are more prevalent in the elderly, and since these movements may be controlled by the balance of brain dopamine D1 and D2 dopamine receptors, we measured the densities of these receptors in 247 postmortem brain striata. In childhood, the densities of D1 and D2 dopamine receptors in the brain striatum rise and fall together. After age 20 years, D1 receptors disappear at 3.2% per decade while D2 receptors disappear at about 2.2% per decade. Overall, therefore, the D1/D2 ratio falls with age. Since perioral motion in rats is dominated by a high D1/D2 ratio, the observed decline in the human D1/D2 ratio with age suggests that the perioral control mechanisms for humans and rats may be different.
Url:
DOI: 10.1002/syn.890010503
Affiliations:
- Autriche, Canada, République populaire de Chine, États-Unis
- Californie, Massachusetts, Ontario, Vienne (Autriche)
- Pékin, Toronto, Vienne (Autriche)
- Université de Toronto
Links toward previous steps (curation, corpus...)
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- to stream Istex, to step Curation: 002150
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- to stream Main, to step Merge: 005752
- to stream Main, to step Curation: 004D52
Le document en format XML
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In childhood, the densities of D1 and D2 dopamine receptors in the brain striatum rise and fall together. After age 20 years, D1 receptors disappear at 3.2% per decade while D2 receptors disappear at about 2.2% per decade. Overall, therefore, the D1/D2 ratio falls with age. Since perioral motion in rats is dominated by a high D1/D2 ratio, the observed decline in the human D1/D2 ratio with age suggests that the perioral control mechanisms for humans and rats may be different.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Canada</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Californie</li><li>Massachusetts</li><li>Ontario</li><li>Vienne (Autriche)</li></region><settlement><li>Pékin</li><li>Toronto</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Reynolds, Gavin P" sort="Reynolds, Gavin P" uniqKey="Reynolds G" first="Gavin P." last="Reynolds">Gavin P. Reynolds</name><name sortKey="Watanabe, Shuzo" sort="Watanabe, Shuzo" uniqKey="Watanabe S" first="Shuzo" last="Watanabe">Shuzo Watanabe</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Seeman, Philip" sort="Seeman, Philip" uniqKey="Seeman P" first="Philip" last="Seeman">Philip Seeman</name></region><name sortKey="Becker, Lawrence E" sort="Becker, Lawrence E" uniqKey="Becker L" first="Lawrence E." last="Becker">Lawrence E. Becker</name><name sortKey="Becker, Lawrence E" sort="Becker, Lawrence E" uniqKey="Becker L" first="Lawrence E." last="Becker">Lawrence E. Becker</name><name sortKey="Bergeron, Catherine" sort="Bergeron, Catherine" uniqKey="Bergeron C" first="Catherine" last="Bergeron">Catherine Bergeron</name><name sortKey="Bzowej, Natalie H" sort="Bzowej, Natalie H" uniqKey="Bzowej N" first="Natalie H." last="Bzowej">Natalie H. Bzowej</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Guan, H" sort="Guan, H" uniqKey="Guan H" first="H." last="Guan">H. Guan</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Bird, E D" sort="Bird, E D" uniqKey="Bird E" first="E. D." last="Bird">E. D. Bird</name></region><name sortKey="Tourtellotte, Wallace W" sort="Tourtellotte, Wallace W" uniqKey="Tourtellotte W" first="Wallace W." last="Tourtellotte">Wallace W. Tourtellotte</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Riederer, Peter" sort="Riederer, Peter" uniqKey="Riederer P" first="Peter" last="Riederer">Peter Riederer</name></region><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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