Propentofylline: A nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia
Identifieur interne : 004154 ( Main/Exploration ); précédent : 004153; suivant : 004155Propentofylline: A nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia
Auteurs : Fiona E. Parkinson [Canada] ; Karl A. Rudolphi [Allemagne] ; Bertil B. Fredholm [Suède]Source :
- General Pharmacology [ 0306-3623 ] ; 1994.
English descriptors
- KwdEn :
- Adenosine (metabolism), Adenosine (physiology), Animals, Biological Transport (drug effects), Brain Ischemia (drug therapy), Cells, Cultured, Cerebrovascular Circulation (drug effects), Depression, Chemical, Excitatory Amino Acid Antagonists, Gerbillinae, Humans, Receptors, Purinergic P1 (drug effects), Xanthines (pharmacology), Xanthines (therapeutic use).
- MESH :
- chemical , drug effects : Receptors, Purinergic P1.
- chemical , metabolism : Adenosine.
- chemical , pharmacology : Xanthines.
- chemical , physiology : Adenosine.
- drug effects : Biological Transport, Cerebrovascular Circulation.
- drug therapy : Brain Ischemia.
- chemical , therapeutic use : Xanthines.
- Animals, Cells, Cultured, Depression, Chemical, Excitatory Amino Acid Antagonists, Gerbillinae, Humans.
Abstract
1. Adenosine is an endogenous neuroprotective agent; stimulation of A1 receptors decreases excitatory amino acid neurotransmission and stimulation of A2 receptors inhibits platelet and neutrophil activation and promotes vasodilation.2. Post-ischemic administration of propentofylline (HWA 285) reduces neuronal damage in gerbils and improves glucose metabolism in all regions of brain in acute stroke patients.3. Propentofylline inhibits the transport of adenosine into cultured cells and increases extracellular adenosine concentrations in ischemic brain. Thus, enhanced stimulation of adenosine receptors may account for some of the neuroprotective effects of this compound.4. Propentofylline inhibits free radical production by cultivated microglia cells, stimulates nerve growth factor production and inhibits cAMP-phosphodiesterase activity. These effects may also be important for neuroprotection.
Url:
DOI: 10.1016/0306-3623(94)90119-8
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">1. Adenosine is an endogenous neuroprotective agent; stimulation of A1 receptors decreases excitatory amino acid neurotransmission and stimulation of A2 receptors inhibits platelet and neutrophil activation and promotes vasodilation.2. Post-ischemic administration of propentofylline (HWA 285) reduces neuronal damage in gerbils and improves glucose metabolism in all regions of brain in acute stroke patients.3. Propentofylline inhibits the transport of adenosine into cultured cells and increases extracellular adenosine concentrations in ischemic brain. Thus, enhanced stimulation of adenosine receptors may account for some of the neuroprotective effects of this compound.4. Propentofylline inhibits free radical production by cultivated microglia cells, stimulates nerve growth factor production and inhibits cAMP-phosphodiesterase activity. These effects may also be important for neuroprotection.</div>
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