Initiating treatment for idiopathic parkinsonism.
Identifieur interne : 004118 ( Main/Exploration ); précédent : 004117; suivant : 004119Initiating treatment for idiopathic parkinsonism.
Auteurs : D B Calne [Canada]Source :
- Neurology [ 0028-3878 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Domperidone, Dopamine Agents.
- drug therapy : Parkinson Disease.
- Humans, Time Factors.
Abstract
The initial decision in the management of idiopathic parkinsonism is whether any pharmacotherapy is indicated. There is no conclusive evidence that treatment is helpful before symptoms start to affect the patient's life, although some neurologists believe that deprenyl, also known as selegiline, could be useful. Once functional deficits begin to interfere with the patient's work or social activities, treating symptoms becomes appropriate. Anticholinergics and amantadine can be used, but their limited benefit is often accompanied by unacceptable adverse effects. Dopaminomimetics are the most satisfactory medications, including levodopa and such artificial dopamine agonists as bromocriptine, pergolide, or lisuride.
PubMed: 7914010
Affiliations:
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Le document en format XML
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