Using chirality as a unique probe of pharmacological properties
Identifieur interne : 003F34 ( Main/Exploration ); précédent : 003F33; suivant : 003F35Using chirality as a unique probe of pharmacological properties
Auteurs : Irving W. Wainer [Canada] ; Julie Ducharme [Canada] ; Camille P. Granvil [Canada] ; Heli Parenteau [Canada] ; Sami Abdullah [Canada]Source :
- Journal of Chromatography A [ 0021-9673 ] ; 1995.
Abstract
The development of enantioselective chromatographic techniques has made it feasible to routinely follow the metabolism and disposition of the separate enantiomers of a chiral drug. These studies are a source of data about in vivo pharmacological processes. The key question is recognition of the fundamental information contained within the results and the application of this data to the development of a deeper understanding of the clinical consequences of stereochemistry. This manuscript presents two examples of how chirality can be used as a unique probe of basic pharmacological properties.
Url:
DOI: 10.1016/0021-9673(94)00749-Y
Affiliations:
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These studies are a source of data about in vivo pharmacological processes. The key question is recognition of the fundamental information contained within the results and the application of this data to the development of a deeper understanding of the clinical consequences of stereochemistry. This manuscript presents two examples of how chirality can be used as a unique probe of basic pharmacological properties.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Wainer, Irving W" sort="Wainer, Irving W" uniqKey="Wainer I" first="Irving W." last="Wainer">Irving W. 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