Induction of RANTES expression by astrocytes and astrocytoma cell lines
Identifieur interne : 003D61 ( Main/Exploration ); précédent : 003D60; suivant : 003D62Induction of RANTES expression by astrocytes and astrocytoma cell lines
Auteurs : Debra A. Barnes [États-Unis] ; Michael Huston [États-Unis] ; Richard Holmes [États-Unis] ; Etty N. Benveniste [États-Unis] ; V. Wee Yong [Canada] ; Peter Scholz [Allemagne] ; H. Daniel Perez [États-Unis]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1996.
Abstract
The cellular infiltrate found during the acute phase of multiple sclerosis (MS) consists of monocytes and activated T cells, suggesting the presence of cell-specific chemotactic signals during the inflammatory response. We examined the ability of human astrocytoma cell lines, as well as primary human and rat astrocytes, to generate a specific member of the intercrine/chemokine family of cytokines, RANTES, when exposed to TNF-α, IL-1β and IFN-γ. Astrocytoma cells as well as primary astrocytes produced RANTES upon incubation with TNF-α or IL-1β. IFN-γ alone did not induce RANTES production by astrocytes, but it potentiated the effects of either TNF-α or IL-1β. Induction of RANTES by TNF-α was mediated by the p55 receptor since a specific anti-p55 antiserum mimicked the effect of TNF-α. These results indicate that human astrocytes are capable of generating a cell-specific chemokine that can account for the inflammatory cellular infiltrate observed during the acute phase of MS, in a process that is regulated by cytokines.
Url:
DOI: 10.1016/S0165-5728(96)00154-3
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002A52
- to stream Istex, to step Curation: 002A52
- to stream Istex, to step Checkpoint: 001771
- to stream Main, to step Merge: 004451
- to stream Main, to step Curation: 003D61
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Induction of RANTES expression by astrocytes and astrocytoma cell lines</title><author><name sortKey="Barnes, Debra A" sort="Barnes, Debra A" uniqKey="Barnes D" first="Debra A." last="Barnes">Debra A. Barnes</name></author><author><name sortKey="Huston, Michael" sort="Huston, Michael" uniqKey="Huston M" first="Michael" last="Huston">Michael Huston</name></author><author><name sortKey="Holmes, Richard" sort="Holmes, Richard" uniqKey="Holmes R" first="Richard" last="Holmes">Richard Holmes</name></author><author><name sortKey="Benveniste, Etty N" sort="Benveniste, Etty N" uniqKey="Benveniste E" first="Etty N." last="Benveniste">Etty N. Benveniste</name></author><author><name sortKey="Yong, V Wee" sort="Yong, V Wee" uniqKey="Yong V" first="V. Wee" last="Yong">V. Wee Yong</name></author><author><name sortKey="Scholz, Peter" sort="Scholz, Peter" uniqKey="Scholz P" first="Peter" last="Scholz">Peter Scholz</name></author><author><name sortKey="Perez, H Daniel" sort="Perez, H Daniel" uniqKey="Perez H" first="H. Daniel" last="Perez">H. Daniel Perez</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:48417EB529530F3E534E7E2E3E2D085A4D9E45D0</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1016/S0165-5728(96)00154-3</idno><idno type="url">https://api-v5.istex.fr/document/48417EB529530F3E534E7E2E3E2D085A4D9E45D0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002A52</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002A52</idno><idno type="wicri:Area/Istex/Curation">002A52</idno><idno type="wicri:Area/Istex/Checkpoint">001771</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001771</idno><idno type="wicri:doubleKey">0165-5728:1996:Barnes D:induction:of:rantes</idno><idno type="wicri:Area/Main/Merge">004451</idno><idno type="wicri:Area/Main/Curation">003D61</idno><idno type="wicri:Area/Main/Exploration">003D61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Induction of RANTES expression by astrocytes and astrocytoma cell lines</title><author><name sortKey="Barnes, Debra A" sort="Barnes, Debra A" uniqKey="Barnes D" first="Debra A." last="Barnes">Debra A. Barnes</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Immunology, Berlex Biosciences, Richmond, CA 94804</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation></affiliation></author><author><name sortKey="Huston, Michael" sort="Huston, Michael" uniqKey="Huston M" first="Michael" last="Huston">Michael Huston</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Immunology, Berlex Biosciences, Richmond, CA 94804</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Holmes, Richard" sort="Holmes, Richard" uniqKey="Holmes R" first="Richard" last="Holmes">Richard Holmes</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Immunology, Berlex Biosciences, Richmond, CA 94804</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Benveniste, Etty N" sort="Benveniste, Etty N" uniqKey="Benveniste E" first="Etty N." last="Benveniste">Etty N. Benveniste</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Yong, V Wee" sort="Yong, V Wee" uniqKey="Yong V" first="V. Wee" last="Yong">V. Wee Yong</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>The Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Que. H3A 2B4</wicri:regionArea><wicri:noRegion>Que. H3A 2B4</wicri:noRegion></affiliation></author><author><name sortKey="Scholz, Peter" sort="Scholz, Peter" uniqKey="Scholz P" first="Peter" last="Scholz">Peter Scholz</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cellular and Molecular Biology, Schering AG, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Perez, H Daniel" sort="Perez, H Daniel" uniqKey="Perez H" first="H. Daniel" last="Perez">H. Daniel Perez</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Department of Immunology, Berlex Biosciences, Richmond, CA 94804</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="207">207</biblScope><biblScope unit="page" to="214">214</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cellular infiltrate found during the acute phase of multiple sclerosis (MS) consists of monocytes and activated T cells, suggesting the presence of cell-specific chemotactic signals during the inflammatory response. We examined the ability of human astrocytoma cell lines, as well as primary human and rat astrocytes, to generate a specific member of the intercrine/chemokine family of cytokines, RANTES, when exposed to TNF-α, IL-1β and IFN-γ. Astrocytoma cells as well as primary astrocytes produced RANTES upon incubation with TNF-α or IL-1β. IFN-γ alone did not induce RANTES production by astrocytes, but it potentiated the effects of either TNF-α or IL-1β. Induction of RANTES by TNF-α was mediated by the p55 receptor since a specific anti-p55 antiserum mimicked the effect of TNF-α. These results indicate that human astrocytes are capable of generating a cell-specific chemokine that can account for the inflammatory cellular infiltrate observed during the acute phase of MS, in a process that is regulated by cytokines.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>États-Unis</li></country><region><li>Alabama</li><li>Berlin</li><li>Californie</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Barnes, Debra A" sort="Barnes, Debra A" uniqKey="Barnes D" first="Debra A." last="Barnes">Debra A. Barnes</name></region><name sortKey="Benveniste, Etty N" sort="Benveniste, Etty N" uniqKey="Benveniste E" first="Etty N." last="Benveniste">Etty N. Benveniste</name><name sortKey="Holmes, Richard" sort="Holmes, Richard" uniqKey="Holmes R" first="Richard" last="Holmes">Richard Holmes</name><name sortKey="Huston, Michael" sort="Huston, Michael" uniqKey="Huston M" first="Michael" last="Huston">Michael Huston</name><name sortKey="Perez, H Daniel" sort="Perez, H Daniel" uniqKey="Perez H" first="H. Daniel" last="Perez">H. Daniel Perez</name></country><country name="Canada"><noRegion><name sortKey="Yong, V Wee" sort="Yong, V Wee" uniqKey="Yong V" first="V. Wee" last="Yong">V. Wee Yong</name></noRegion></country><country name="Allemagne"><region name="Berlin"><name sortKey="Scholz, Peter" sort="Scholz, Peter" uniqKey="Scholz P" first="Peter" last="Scholz">Peter Scholz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003D61 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003D61 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:48417EB529530F3E534E7E2E3E2D085A4D9E45D0
|texte= Induction of RANTES expression by astrocytes and astrocytoma cell lines
}}
| This area was generated with Dilib version V0.6.29. |  |