The immunotoxicity of environmental contaminants to marine wildlife: A review
Identifieur interne : 003D28 ( Main/Exploration ); précédent : 003D27; suivant : 003D29The immunotoxicity of environmental contaminants to marine wildlife: A review
Auteurs : Peter S. Ross ; Rik L. De Swart [Pays-Bas] ; Henk Van Loveren [Pays-Bas] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Joseph G. Vos [Pays-Bas]Source :
- Annual Review of Fish Diseases [ 0959-8030 ] ; 1996.
Abstract
Virus-associated mass mortalities among several marine mammal populations inhabiting industrialized coastal areas have generated an interest in wildlife immunotoxicology. Despite the isolation of previously uncharacterized viruses from victims, a contribution of immunotoxic contaminants to the severity of the outbreaks could not be ruled out. Fish-eating marine mammals, including seals, occupy high trophic levels in the aquatic food chain, and accumulate high levels of contaminants including polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychorinated dibenzofurans (PCDFs). Such chemicals have been found to be immunotoxic at low doses in studies of laboratory animals. While associations have been established between environmental contaminants and various adverse biological effects in certain free-ranging seal populations, evidence for immunotoxicity has, until recently, been lacking. To this end, we carried out an immunotoxicological study, in which captive harbor seals were fed herring from either relatively uncontaminated sites of the Atlantic Ocean, or from the highly contaminated Baltic Sea. In this review, we summarize the contaminant-related immunosuppression observed in the captive group of seals fed herring from the Baltic Sea, and discuss these results in the context of what is currently known about outbreaks of virus infection, comparative immunology, and environmental contaminants. We also describe two parallel studies, in which laboratory rats exposed as adults or perinatally to the contaminants in the Baltic Sea herring, exhibited immunotoxicity. On the basis of these and other studies, we conclude that complex mixtures of environmental contaminants may represent a real immunotoxic risk to free-ranging marine mammals in many areas of Europe and North America.
Url:
DOI: 10.1016/S0959-8030(96)90011-3
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002885
- to stream Istex, to step Curation: 002885
- to stream Istex, to step Checkpoint: 001738
- to stream Main, to step Merge: 004418
- to stream Main, to step Curation: 003D28
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The immunotoxicity of environmental contaminants to marine wildlife: A review</title>
<author><name sortKey="Ross, Peter S" sort="Ross, Peter S" uniqKey="Ross P" first="Peter S." last="Ross">Peter S. Ross</name>
</author>
<author><name sortKey="De Swart, Rik L" sort="De Swart, Rik L" uniqKey="De Swart R" first="Rik L." last="De Swart">Rik L. De Swart</name>
</author>
<author><name sortKey="Van Loveren, Henk" sort="Van Loveren, Henk" uniqKey="Van Loveren H" first="Henk" last="Van Loveren">Henk Van Loveren</name>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
</author>
<author><name sortKey="Vos, Joseph G" sort="Vos, Joseph G" uniqKey="Vos J" first="Joseph G." last="Vos">Joseph G. Vos</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:8E7BC94C8F6E27A78465BFD4EC715036F07EFA66</idno>
<date when="1996" year="1996">1996</date>
<idno type="doi">10.1016/S0959-8030(96)90011-3</idno>
<idno type="url">https://api-v5.istex.fr/document/8E7BC94C8F6E27A78465BFD4EC715036F07EFA66/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002885</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002885</idno>
<idno type="wicri:Area/Istex/Curation">002885</idno>
<idno type="wicri:Area/Istex/Checkpoint">001738</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001738</idno>
<idno type="wicri:doubleKey">0959-8030:1996:Ross P:the:immunotoxicity:of</idno>
<idno type="wicri:Area/Main/Merge">004418</idno>
<idno type="wicri:Area/Main/Curation">003D28</idno>
<idno type="wicri:Area/Main/Exploration">003D28</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">The immunotoxicity of environmental contaminants to marine wildlife: A review</title>
<author><name sortKey="Ross, Peter S" sort="Ross, Peter S" uniqKey="Ross P" first="Peter S." last="Ross">Peter S. Ross</name>
<affiliation><wicri:noCountry code="subField">4B2</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Swart, Rik L" sort="De Swart, Rik L" uniqKey="De Swart R" first="Rik L." last="De Swart">Rik L. De Swart</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Institute of Virology, Erasmus University Rotterdam, 3015 GE Rotterdam</wicri:regionArea>
<wicri:noRegion>3015 GE Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Loveren, Henk" sort="Van Loveren, Henk" uniqKey="Van Loveren H" first="Henk" last="Van Loveren">Henk Van Loveren</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>National Institute of Public Health and the Environment, 3720 BA Bilthoven</wicri:regionArea>
<wicri:noRegion>3720 BA Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Seal Rehabilitation and Research Centre, 9968 AG Pieterburen</wicri:regionArea>
<wicri:noRegion>9968 AG Pieterburen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vos, Joseph G" sort="Vos, Joseph G" uniqKey="Vos J" first="Joseph G." last="Vos">Joseph G. Vos</name>
<affiliation wicri:level="4"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Veterinary Pathology, Utrecht University, 3508 TD Utrecht</wicri:regionArea>
<orgName type="university">Université d'Utrecht</orgName>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annual Review of Fish Diseases</title>
<title level="j" type="abbrev">ARFD</title>
<idno type="ISSN">0959-8030</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1996">1996</date>
<biblScope unit="volume">6</biblScope>
<biblScope unit="supplement">C</biblScope>
<biblScope unit="page" from="151">151</biblScope>
<biblScope unit="page" to="165">165</biblScope>
</imprint>
<idno type="ISSN">0959-8030</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0959-8030</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Virus-associated mass mortalities among several marine mammal populations inhabiting industrialized coastal areas have generated an interest in wildlife immunotoxicology. Despite the isolation of previously uncharacterized viruses from victims, a contribution of immunotoxic contaminants to the severity of the outbreaks could not be ruled out. Fish-eating marine mammals, including seals, occupy high trophic levels in the aquatic food chain, and accumulate high levels of contaminants including polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychorinated dibenzofurans (PCDFs). Such chemicals have been found to be immunotoxic at low doses in studies of laboratory animals. While associations have been established between environmental contaminants and various adverse biological effects in certain free-ranging seal populations, evidence for immunotoxicity has, until recently, been lacking. To this end, we carried out an immunotoxicological study, in which captive harbor seals were fed herring from either relatively uncontaminated sites of the Atlantic Ocean, or from the highly contaminated Baltic Sea. In this review, we summarize the contaminant-related immunosuppression observed in the captive group of seals fed herring from the Baltic Sea, and discuss these results in the context of what is currently known about outbreaks of virus infection, comparative immunology, and environmental contaminants. We also describe two parallel studies, in which laboratory rats exposed as adults or perinatally to the contaminants in the Baltic Sea herring, exhibited immunotoxicity. On the basis of these and other studies, we conclude that complex mixtures of environmental contaminants may represent a real immunotoxic risk to free-ranging marine mammals in many areas of Europe and North America.</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
</country>
<region><li>Utrecht (province)</li>
</region>
<settlement><li>Utrecht</li>
</settlement>
<orgName><li>Université d'Utrecht</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Ross, Peter S" sort="Ross, Peter S" uniqKey="Ross P" first="Peter S." last="Ross">Peter S. Ross</name>
</noCountry>
<country name="Pays-Bas"><noRegion><name sortKey="De Swart, Rik L" sort="De Swart, Rik L" uniqKey="De Swart R" first="Rik L." last="De Swart">Rik L. De Swart</name>
</noRegion>
<name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<name sortKey="Van Loveren, Henk" sort="Van Loveren, Henk" uniqKey="Van Loveren H" first="Henk" last="Van Loveren">Henk Van Loveren</name>
<name sortKey="Vos, Joseph G" sort="Vos, Joseph G" uniqKey="Vos J" first="Joseph G." last="Vos">Joseph G. Vos</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003D28 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003D28 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:8E7BC94C8F6E27A78465BFD4EC715036F07EFA66 |texte= The immunotoxicity of environmental contaminants to marine wildlife: A review }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |