ParkinsonCanadaV1, Main, Exploration, bibRecord, 003504

Familial Alzheimer's disease: Site of mutation influences clinical phenotype

Identifieur interne : 003504 ( Main/Exploration ); précédent : 003503; suivant : 003505

Familial Alzheimer's disease: Site of mutation influences clinical phenotype

Auteurs : C. F. Lippa [États-Unis] ; J. M. Swearer [États-Unis] ; K. J. Kane [États-Unis] ; D. Nochlin [États-Unis] ; T. D. Bird [États-Unis] ; B. Ghetti [États-Unis] ; L. E. Nee [États-Unis] ; P. St. George-Hyslop [Canada] ; D. A. Pollen [États-Unis] ; D. A. Drachman [États-Unis]

Source :

Annals of Neurology [ 0364-5134 ] ; 2000-09.

RBID : ISTEX:7DF967544A24D6D5BCB4D9620B502CC2CBE160F1

Abstract

Alzheimer's disease (AD) is caused by multiple genetic and/or environmental etiologies. Because differences in the genetically determined pathogenesis may cause differences in the phenotype, we examined age at onset and age at death in 90 subjects with dominantly inherited AD due to different mutations (amyloid precursor protein, presenilin‐1, and presenilin‐2 genes). We found that among patients with dominantly inherited AD, genetic factors influence both age at onset and age at death. Ann Neurol 2000;48:376–379

Url:

https://api-v5.istex.fr/document/7DF967544A24D6D5BCB4D9620B502CC2CBE160F1/fulltext/pdf

DOI: 10.1002/1531-8249(200009)48:3<376::AID-ANA13>3.0.CO;2-U

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Alzheimer's disease (AD) is caused by multiple genetic and/or environmental etiologies. Because differences in the genetically determined pathogenesis may cause differences in the phenotype, we examined age at onset and age at death in 90 subjects with dominantly inherited AD due to different mutations (amyloid precursor protein, presenilin‐1, and presenilin‐2 genes). We found that among patients with dominantly inherited AD, genetic factors influence both age at onset and age at death. Ann Neurol 2000;48:376–379</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Familial Alzheimer's disease: Site of mutation influences clinical phenotype

Familial Alzheimer's disease: Site of mutation influences clinical phenotype

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri