ParkinsonCanadaV1, Main, Exploration, bibRecord, 003404

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Identifieur interne : 003404 ( Main/Exploration ); précédent : 003403; suivant : 003405

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Auteurs : Paul B. Fitzgerald [Australie] ; Shitij Kapur [Canada] ; Michael P. Caligiuri [États-Unis] ; Corey Jones [Canada] ; Simone Silvestri [Canada] ; Gary Remington [Canada] ; Robert B. Zipursky [Canada]

Source :

Neuropsychopharmacology [ 0893-133X ] ; 2000.

RBID : ISTEX:B7DDDBD2B6F921B503DFE8E817A743649BE63AB1

Abstract

Extrapyramidal side-effects (EPSE) of antipsychotic medication are related to the occupancy of dopamine D2 receptors and there appears to be a threshold of D2 occupancy below which clinically EPSE are unlikely to occur. It is unclear whether there are motor changes produced by ‘subthreshold’ levels of D2 occupancy that are not detectable by clinical examination. This study was designed to investigate whether a number of electromechanical instrumental techniques could detect ‘subthreshold’ motor changes and whether these changes correlate with dopamine D2 occupancy as measured by [11C]-raclopride PET scan. Twenty medication naı̈ve patients were studied before and during treatment with low dose haloperidol. Instrumental techniques detected an asymmetrical worsening in motor function with drug treatment despite the failure of the group to experience significant EPSE. These changes did not correlate with D2 occupancy and measurements of rigidity, tremor, and bradykinesia did not closely inter-correlate.

Url:

https://api-v5.istex.fr/document/B7DDDBD2B6F921B503DFE8E817A743649BE63AB1/fulltext/pdf

DOI: 10.1016/S0893-133X(99)00081-0

Affiliations:

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Le document en format XML

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri